A1 Refereed original research article in a scientific journal

A multifunctional nanocomplex for enhanced cell uptake, endosomal escape and improved cancer therapeutic effect




AuthorsAlmeida PV, Shahbazi MA, Correia A, Makila E, Kemell M, Salonen J, Hirvonen J, Santos HA

PublisherFUTURE MEDICINE LTD

Publication year2017

JournalNanomedicine

Journal name in sourceNANOMEDICINE

Journal acronymNANOMEDICINE-UK

Volume12

Issue12

First page 1401

Last page1420

Number of pages20

ISSN1743-5889

eISSN1748-6963

DOIhttps://doi.org/10.2217/nnm-2017-0034


Abstract
Aim: To evaluate the chemotherapeutic potential of a novel multifunctional nanocomposite encapsulating both porous silicon (PSi) and gold (Au) nanoparticles in a polymeric nanocomplex. Materials & methods: The nanocomposite was physicochemically characterized and evaluated in vitro for biocompatibility, cellular internalization, endosomolytic properties, cytoplasmatic drug delivery and chemotherapeutic efficacy. Results: The nanocomposites were successfully produced and exhibited adequate physicochemical properties and superior in vitro cyto- and hemocompatibilities. The encapsulation of PSi nanoparticles in the nanocomplexes significantly enhanced their cellular internalization and enabled their endosomal escape, resulting in the efficient cytoplasmic delivery of these nanosystems. Sorafenibloaded nanocomposites showed a potent in vitro antiproliferative effect on MDA-MB-231 breast cancer cells. Conclusion: The multifunctional nanocomposite herein presented exhibits great potential as a chemotherapeutic nanoplatform.



Last updated on 2024-26-11 at 12:15