A1 Journal article – refereed
High levels of dopamine activity in the basal ganglia of cigarette smokers




List of Authors: Salokangas RKR, Vilkman H, Ilonen T, Taiminen T, Bergman J, Haaparanta M, Solin O, Alanen A, Syvalahti E, Hietala J
Publisher: AMER PSYCHIATRIC PRESS, INC
Publication year: 2000
Journal: American Journal of Psychiatry
Journal name in source: AMERICAN JOURNAL OF PSYCHIATRY
Journal acronym: AM J PSYCHIAT
Volume number: 157
ISSN: 0002-953X

Abstract
Objective: The authors' goal was to study presynaptic dopamine activity in smoking and nonsmoking human subjects in vivo. Method: [F-18]Fluorodopa ([F-18]DOPA) uptake K-i values in the basal ganglia of nine smoking and 10 nonsmoking healthy men were measured with positron emission tomography Results: Significantly higher [F-18]DOPA uptake was observed in both the putamen (average 17.3% higher) and the caudate (average 30.4% higher) of smokers than in those of nonsmokers. Conclusions: Smoking is related to greater dopamine activity in the human basal ganglia. Nicotine-induced dopamine activity may be a relevant mechanism in dependence on cigarette smoking.

Last updated on 2019-21-08 at 21:35