Refereed journal article or data article (A1)
Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins
List of Authors: Daria Bulanova, Aleksandr Ianevski, Andrii Bugai, Yevhen Akimov, Suvi Kuivanen, Henrik Paavilainen, Laura Kakkola, Jatin Nandania, Laura Turunen, Tiina Ohman, Hanna Ala-Hongisto, Hanna M. Pesonen, Marika S. Kuisma, Anni Honkimaa, Emma L. Walton, Valentyn Oksenych, Martina B. Lorey, Dmitry Guschin, Jungmin Shim, Jinhee Kim, Thoa T. Than, So Young Chang, Veijo Hukkanen, Evgeny Kulesskiy, Varpu S. Marjomaki, Ilkka Julkunen, Tuula A. Nyman, Sampsa Matikainen, Jani S. Saarela, Famara Sane, Didier Hober, Gülsah Gabriel, Jef K. De Brabander, Miika Martikainen, Marc P. Windisch, Ji-Young Min, Roberto Bruzzone, Tero Aittokallio, Markus Vähä-Koskela, Olli Vapalahti, Arto Pulk, Vidya Velagapudi, Denis E. Kainov
Publisher: MDPI AG
Publication year: 2017
Journal: Viruses
Journal name in source: Viruses
Volume number: 9
Issue number: 10
Number of pages: 15
ISSN: 1999-4915
DOI: http://dx.doi.org/10.3390/v9100271
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/27627275
Viral diseases remain serious threats to public health because of the
shortage of effective means of control. To combat the surge of viral
diseases, new treatments are urgently needed. Here we show that
small-molecules, which inhibit cellular anti-apoptotic Bcl-2 proteins
(Bcl-2i), induced the premature death of cells infected with different
RNA or DNA viruses, whereas, at the same concentrations, no toxicity was
observed in mock-infected cells. Moreover, these compounds limited
viral replication and spread. Surprisingly, Bcl-2i also induced the
premature apoptosis of cells transfected with viral RNA or plasmid DNA
but not of mock-transfected cells. These results suggest that Bcl-2i
sensitizes cells containing foreign RNA or DNA to apoptosis. A
comparison of the toxicity, antiviral activity, and side effects of six
Bcl-2i allowed us to select A-1155463 as an antiviral lead candidate.
Thus, our results pave the way for the further development of Bcl-2i for
the prevention and treatment of viral diseases.
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