A1 Journal article – refereed
Obesity-associated intestinal insulin resistance is ameliorated after bariatric surgery




List of Authors: Makinen J, Hannukainen JC, Karmi A, Immonen HM, Soinio M, Nelimarkka L, Savisto N, Helmio M, Ovaska J, Salminen P, Iozzo P, Nuutila P
Publisher: SPRINGER
Publication year: 2015
Journal: Diabetologia
Journal name in source: DIABETOLOGIA
Journal acronym: DIABETOLOGIA
Volume number: 58
Issue number: 5
Number of pages: 8
ISSN: 0012-186X
eISSN: 1432-0428

Abstract


Conclusions/interpretation This study shows that insulin is a potent stimulator of GU in the healthy intestine and that intestinal insulin resistance is ameliorated after bariatric surgery. In our study, obese individuals had intestinal insulin resistance regardless of their glycaemic status. Persistent changes in intestinal glucose metabolism are likely to influence both local processes in the gut and systemic glucose homeostasis.



Last updated on 2019-20-07 at 12:58