A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

A cross-sectional comparative study of gut bacterial community of Indian and Finnish children




TekijätKumbhare SV, Kumar H, Chowdhury SP, Dhotre DP, Endo A, Matto J, Ouwehand AC, Rautava S, Joshi R, Patil NP, Patil RH, Isolauri E, Bavdekar AR, Salminen S, Shouche YS

KustantajaNATURE PUBLISHING GROUP

Julkaisuvuosi2017

JournalScientific Reports

Tietokannassa oleva lehden nimiSCIENTIFIC REPORTS

Lehden akronyymiSCI REP-UK

Artikkelin numeroARTN 10555

Vuosikerta7

Sivujen määrä13

ISSN2045-2322

DOIhttps://doi.org/10.1038/s41598-017-11215-y

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/26620802


Tiivistelmä
The human gut microbiome plays a crucial role in the compositional development of gut microbiota. Though well documented in western pediatrics population, little is known about how various host conditions affect populations in different geographic locations such as the Indian subcontinent. Given the impact of distinct environmental conditions, our study assess the gut bacterial diversity of a small cohort of Indian and Finnish children and investigated the influence of FUT2 secretor status and birth mode on the gut microbiome of these populations. Using multiple profiling techniques, we show that the gut bacterial community structure in 13-14-year-old Indian (n = 47) and Finnish (n = 52) children differs significantly. Specifically, Finnish children possessed higher Blautia and Bifidobacterium, while genera Prevotella and Megasphaera were predominant in Indian children. Our study also demonstrates a strong influence of FUT2 and birth mode variants on specific gut bacterial taxa, influence of which was noticed to differ between the two populations under study.

Ladattava julkaisu

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Last updated on 2024-26-11 at 19:12