A1 Journal article – refereed
The effect of secondary structure on cleavage of the phosphodiester bonds of RNA




List of Authors: Mikkola S, Kaukinen U, Lonnberg H
Publisher: HUMANA PRESS INC
Publication year: 2001
Journal: Cell Biochemistry and Biophysics
Journal name in source: CELL BIOCHEMISTRY AND BIOPHYSICS
Journal acronym: CELL BIOCHEM BIOPHYS
Volume number: 34
Issue number: 1
ISSN: 1085-9195

Abstract
This review discusses the effects the secondary structure of an RNA molecule has on the inherent reactivity of its phosphodiester bonds, and on the catalytic activity of metal ion-based cleaving agents. The basic principles of the intramolecular transesterification of RNA phosphodiester bonds, particularly cleavage, are first briefly described. Studies of the structural effects on the cleavage, in the absence and in the presence of metal ion catalysts, are then reviewed, and the sources of the reactivity differences observed in different structures are discussed.


Research Areas


Last updated on 2019-21-08 at 21:17