A2 Review article in a scientific journal
A mechanistic overview of health associated effects of low levels of organochlorine and organophosphorous pesticides




List of Authors: Vasilis P Androutsopoulos, Antonio F Hernandez, Jyrki Liesivuori, Aristidis M Tsatsakis
Publisher: Elsevier
Publication year: 2013
Journal: Food and Chemical Toxicology
Journal acronym: Toxicology
Volume number: 307
Number of pages: 6
ISSN: 0300-483X

Abstract
Organochlorine and organophosphate pesticides are compounds that can be detected in human populations as a result of occupational or residential exposure. Despite their occurrence in considerably low levels in humans, their biological effects are hazardous since they interact with a plethora of enzymes, proteins, receptors and transcription factors. In this review we summarize the cell and molecular effects of organochlorine and organophosphate pesticides with respect to their toxicity, with particular emphasis on glucose and lipid metabolism, their interaction with some members of the nuclear receptor family of ligand-activated transcription factors, including the steroid and peroxisome proliferator activated receptors that changes the expression of genes involved in lipid metabolism and xenobiotic detoxification. More importantly, evidence regarding the metabolic degradation of pesticides and their accumulation in tissues is presented. Potential non-cholinergic mechanisms after long-term low-dose organophosphate exposure resulting in neurodevelopmental outcomes and neurodegeneration are also addressed. We conclude that the mechanism of pesticide-mediated toxicity is a combination of various enzyme-inhibitory, metabolic and transcriptional events acting at the cellular and molecular level.


Internal Authors/Editors

Last updated on 2019-21-08 at 19:57