A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Vacuum ultraviolet photon-mediated production of [F-18]F-2
Tekijät: Krzyczmonik A, Keller T, Kirjavainen AK, Forsback S, Solin O
Kustantaja: WILEY
Julkaisuvuosi: 2017
Journal: Journal of Labelled Compounds and Radiopharmaceuticals
Tietokannassa oleva lehden nimi: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
Lehden akronyymi: J LABELLED COMPD RAD
Vuosikerta: 60
Numero: 4
Aloitussivu: 186
Lopetussivu: 193
Sivujen määrä: 8
ISSN: 0362-4803
eISSN: 1099-1344
DOI: https://doi.org/10.1002/jlcr.3489
Verkko-osoite: http://onlinelibrary.wiley.com/doi/10.1002/jlcr.3489/epdf
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/22366543
The chemistry of F-2 and its derivatives are amenable to facile aliphatic or aromatic substitution, as well as electrophilic addition. The main limitation in the use of [F-18]F-2 for radiopharmaceutical synthesis is the low specific activity achieved by the traditional methods of production. The highest specific activities, 55GBq/mol, for [F-18]F-2 have been achieved so far by using electrical discharge in the post-target production of [F-18]F-2 gas from [F-18]CH3F. We demonstrate that [F-18]F-2 is produced by illuminating a gas mixture of neon/F-2/[F-18]CH3F with vacuum ultraviolet photons generated by an excimer laser. We tested several illumination chambers and production conditions. The effects of the initial amount of [F-18]F-, amount of carrier F-2, and number of 193-nm laser pulses at constant power were evaluated regarding radiochemical yield and specific activity. The specific activity attained for [F-18]F-2-derived [F-18]NFSi was 10.3 +/- 0.9GBq/mol, and the average radiochemical yield over a wide range of conditions was 6.7% from [F-18]F-. The production can be improved by optimization of the synthesis device and procedures. The use of a commercially available excimer laser and the simplicity of the process can make this method relatively easy for adaptation in radiochemistry laboratories.
Ladattava julkaisu This is an electronic reprint of the original article. |