A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Fabrication, characterization and evaluation of bacterial cellulose-based capsule shells for oral drug delivery
Tekijät: Ullah H, Badshah M, Makila E, Salonen J, Shahbazi MA, Santos HA, Khan T
Kustantaja: SPRINGER
Julkaisuvuosi: 2017
Journal: Cellulose
Tietokannassa oleva lehden nimi: CELLULOSE
Lehden akronyymi: CELLULOSE
Vuosikerta: 24
Numero: 3
Aloitussivu: 1445
Lopetussivu: 1454
Sivujen määrä: 10
ISSN: 0969-0239
eISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-017-1202-4
Tiivistelmä
Bacterial cellulose (BC) was investigated for the first time for the preparation of capsule shells for immediate and sustained release of drugs. The prepared capsule shells were characterized using X-ray diffraction, scanning electron microscopy and Fourier transform infrared spectroscopy. The BC capsule shells were studied for drug release using an USP type-I dissolution apparatus. Irrespective of the drying method and the thickness of the BC sheet, the capsule shells displayed an immediate drug release profile. Moreover, the addition of release-retardant cellulosic polymers sustained the drug release having first-order kinetics for hydroxypropylmethylcellulose and carboxymethyl cellulose sodium with R (2) values of 0.9995 and 0.9954, respectively. Furthermore, these capsules shells remained buoyant in 0.1 N HCl (pH 1.2) solution up to 12 h. This study showed that BC is a promising alternative to gelatin capsules with both immediate and sustained drug release properties depending upon the compositions of the encapsulated materials.
Bacterial cellulose (BC) was investigated for the first time for the preparation of capsule shells for immediate and sustained release of drugs. The prepared capsule shells were characterized using X-ray diffraction, scanning electron microscopy and Fourier transform infrared spectroscopy. The BC capsule shells were studied for drug release using an USP type-I dissolution apparatus. Irrespective of the drying method and the thickness of the BC sheet, the capsule shells displayed an immediate drug release profile. Moreover, the addition of release-retardant cellulosic polymers sustained the drug release having first-order kinetics for hydroxypropylmethylcellulose and carboxymethyl cellulose sodium with R (2) values of 0.9995 and 0.9954, respectively. Furthermore, these capsules shells remained buoyant in 0.1 N HCl (pH 1.2) solution up to 12 h. This study showed that BC is a promising alternative to gelatin capsules with both immediate and sustained drug release properties depending upon the compositions of the encapsulated materials.
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