A1 Journal article – refereed
Pharmacokinetics of [F-18]flutemetamol in wild-type rodents and its binding to beta amyloid deposits in a mouse model of Alzheimer's disease




List of Authors: Snellman A, Rokka J, Lopez-Picon FR, Eskola O, Wilson I, Farrar G, Scheinin M, Solin O, Rinne JO, Haaparanta-Solin M
Publisher: SPRINGER SPRINGER
Publication year: 2012
Journal: European Journal of Nuclear Medicine and Molecular Imaging
Journal name in source: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Journal acronym: EUR J NUCL MED MOL I
Number in series: 11
Volume number: 39
Issue number: 11
Number of pages: 12
ISSN: 1619-7070

Abstract
Based on its pharmacokinetic profile, [F-18]flutemetamol showed potential as a PET tracer for preclinical imaging. It showed good brain uptake and was bound to A beta deposits in the brain of Tg2576 mice. However, its high lipophilicity might complicate the analysis of PET data, particularly in small-animal imaging.

Last updated on 2019-21-08 at 22:04