Refereed journal article or data article (A1)

6-mo aerobic exercise intervention enhances the lipid peroxide transport function of HDL




List of AuthorsTiainen S, Luoto R, Ahotupa M, Raitanen J, Vasankari T

Publication year2016

JournalFree Radical Research

Volume number50

Issue number11

Start page1279

End page1285

Number of pages7

ISSN1071-5762

DOIhttp://dx.doi.org/10.1080/10715762.2016.1252040


Abstract

During acute exercise, the concentration of oxidized high-density lipoprotein (HDL) lipids (ox-HDL) is reported to increase suggesting that HDL may function in decreasing the concentration of oxidized low-density lipoprotein (LDL) lipids. However, the effect of exercise intervention on the lipid peroxide transport function of HDL is unknown. A randomized controlled trial with sedentary women (N = 161), aged 43-63, with no current use of hormone therapy, were randomized into a 6-month (mo) exercise group and a control group. During the 6-mo intervention, the concentration of ox-HDL increased in the exercise group by 5% and decreased in the control group by 2% (p = .003). Also, the ratio of ox-HDL to HDL-cholesterol increased by 5% in the exercise group and decreased by 1.5% in the control group (p = .036). The concentrations of cholesteryl ester transfer protein (CETP) and adiponectin did not change during the intervention. The concentration of serum triglycerides trended to decrease by 6% in the intervention group (p = .051). We found that the concentration of ox-HDL increased during the 6-mo aerobic exercise intervention, but the increase was not related to changes in the levels of CETP or adiponectin. These results, together with earlier studies, suggest that HDL has an active role in the reverse transport of lipid peroxides.


Last updated on 2021-24-06 at 09:30