A1 Journal article – refereed
Sex, age, and time to cardioversion. Risk factors for cardioversion of acute atrial fibrillation from the FinCV study

List of Authors: Bah Aissa, Nuotio Ilpo, Grönberg Toni, Ylitalo Antti, Airaksinen K.E. Juhani, Hartikainen Juha E.K.
Publisher: Taylor & Francis
Publication year: 2017
Journal: Annals of Medicine
Volume number: 49
Issue number: 3
eISSN: 1365-2060


Background: Female sex, old age, and time to cardioversion increase the risk of thromboembolic complications (TEC) after cardioversion of atrial fibrillation (AF) < 48 h. The interaction of these variables is not known. We investigated the interaction of sex, age, and time to electrical cardioversion (ECV) on TEC in anticoagulant-naive patients with acute AF.

Methods and results: The primary outcome was a TEC within 30 days following ECV. Patients were divided into three age groups and time to cardioversion into <12 h and ≥12 h in 4715 ECVs. TEC occurred in 40 (0.8%) patients. In multivariate analysis, female sex, time to ECV, and vascular disease were independent predictors of TEC. For patients ≤75 cardioverted within 12 h, the incidence of TEC was low. In patients >75 TEC increased in both sexes and particularly in women (1.4% vs. 0.9%, p = 0.03). When ECVs exceeded 12 h, the risk of TEC was two- to four-fold higher in women in all age groups.

Conclusions: The risk of TEC increases substantially in patients >75 and ECVs ≥12 h, particularly in women. Time to cardioversion should be added to risk-stratification of ECVs of acute AF.

Last updated on 2019-21-08 at 20:24