A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

1H NMR-based metabolic fingerprinting of urine metabolites after consumption of lingonberries (Vaccinium vitis-idaea) with a high-fat meal




TekijätLehtonen HM, Lindstedt A, Järvinen R, Sinkkonen J, Graça G, Viitanen M, Kallio H, Gil AM

ToimittajaElsevier

KustantajaELSEVIER SCI LTD

Julkaisuvuosi2013

JournalFood Chemistry

Tietokannassa oleva lehden nimiFOOD CHEMISTRY

Lehden akronyymiFOOD CHEM

Numero sarjassa2-3

Vuosikerta138

Numero2-3

Aloitussivu982

Lopetussivu990

Sivujen määrä9

ISSN0308-8146

DOIhttps://doi.org/10.1016/j.foodchem.2012.10.081


Tiivistelmä
The use of NMR metabolomics in clinical trials is growing; however, reports of postprandial experiments in humans are scarce. The present study investigated whether consumption of lingonberries as a supplement to an oil-rich meal modifies the postprandial fingerprints of human urine. Urine samples were analysed by H-1 NMR, and untargeted multivariate analysis was applied to the data for comprehensive fingerprinting. A clear separation of postprandial lingonberry meal samples was revealed. To evaluate statistical differences, a targeted approach was applied for the informative spectral areas. Significantly (p < 0.05) increased levels of polyphenol metabolites, hippuric acid and 4-hydroxyhippuric acid, and decreased creatinine and dimethylamine levels were the major explanations for the grouping of the postprandial samples after the different meals. Thus, inclusion of polyphenol-rich lingonberry powder in a rapeseed oil-rich meal modifies the metabolic profile of urine which may be used to reveal both consumption of berries and health-promoting changes in the common metabolism. (C) 2012 Elsevier Ltd. All rights reserved.



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