A1 Journal article – refereed
Removal of cell surface heparan sulfate increases TACE activity and cleavage of ErbB4 receptor

List of Authors: Maatta JA, Olli K, Henttinen T, Tuittila MT, Elenius K, Salmivirta M
Publication year: 2009
Journal: BMC Cell Biology
Journal name in source: BMC CELL BIOLOGY
Journal acronym: BMC CELL BIOL
Volume number: 10
Number of pages: 7
ISSN: 1471-2121

Conclusion: In this communication, we suggest a novel role for cell surface heparan sulfate. Removal of cell surface heparan sulfate led to increased formation of ErbB4 intracellular domain. As ErbB4 intracellular domain has previously been shown to promote cell survival this finding may indicate a novel mechanism how HS degradation active in tumor tissue may favor cell survival.

Last updated on 2019-20-07 at 13:53