A1 Refereed original research article in a scientific journal

Genetic Variants Associated With Male Pedophilic Sexual Interest




AuthorsKatarina Alanko, Annika Gunst, Andreas Mokros, Pekka Santtila

PublisherWILEY-BLACKWELL

Publication year2016

JournalJournal of Sexual Medicine

Journal name in sourceJOURNAL OF SEXUAL MEDICINE

Journal acronymJ SEX MED

Volume13

Issue5

First page 835

Last page842

Number of pages8

ISSN1743-6095

eISSN1743-6109

DOIhttps://doi.org/10.1016/j.jsxm.2016.02.170


Abstract
Introduction: The etiology of sexual preference disorders (paraphilias) in general and pedophilia in particular remains unknown. There are some indications of biological factors related to pedophilic interest and pedophilic disorder.Aim: To examine single-nucleotide polymorphisms (SNPs) potentially associated with pedophilic sexual interest.Methods: The sample consisted of 1,672 men 18 to 45 years old from the Genetics of Sex and Aggression sample who had submitted saliva samples. Fifty-four SNPs were genotyped and relevant SNPs were analyzed.Main Outcome Measures: A self-report questionnaire designed specifically for the Genetics of Sex and Aggression sample was used to measure sexual interest in and sexual behavior toward children and adolescents. DNA extraction and genotyping were used to measure possible associations between male pedophilia and SNPs.Results: Before controlling for multiple testing, statistically significant associations were found for SNPs linked to androgen, estrogen, prolactin, corticotrophin, serotonin, and oxytocin. No associations remained significant after controlling for multiple testing.Conclusion: The results of the present study suggest a complex biological mechanism affecting adult sexual interest in children. Very small effect sizes characterized the findings, and several polymorphisms related to different hormonal functioning were initially related to the phenotype. Copyright (C) 2016, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.



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