Refereed journal article or data article (A1)

Parametric Binding Images of the TSPO Ligand F-18-DPA-714




List of AuthorsGolla SSV, Boellaard R, Oikonen V, Hoffmann A, van Berckel BNM, Windhorst AD, Virta J, te Beek ET, Groeneveld GJ, Haaparanta-Solin M, Luoto P, Savisto N, Solin O, Valencia R, Thiele A, Eriksson J, Schuit RC, Lammertsma AA, Rinne JO

PublisherSOC NUCLEAR MEDICINE INC

Publication year2016

JournalJournal of Nuclear Medicine

Journal name in sourceJOURNAL OF NUCLEAR MEDICINE

Journal acronymJ NUCL MED

Volume number57

Issue number10

Start page1543

End page1547

Number of pages5

ISSN0161-5505

eISSN1535-5667

DOIhttp://dx.doi.org/10.2967/jnumed.116.173013


Abstract
F-18-labeled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-alpha]pyrimidine-3-yl)acetamide (DPA-714) is a radio-ligand for the 18-kDa translocator protein. The purpose of the present study was to identify the best method for generating quantitative parametric images of F-18-DPA-714 binding. Methods: Ninety-minute dynamic F-18-DPA-714 PET scans with full arterial sampling from 6 healthy subjects and 9 Alzheimer disease (AD) patients were used. Plasma-input based Logan graphical analysis and spectral analysis were used to generate parametric volume of distribution (V-T) images. Five versions of Ichise, reference Logan, and 2 basis function implementations (receptor parametric mapping and simplified reference tissue model 2 [SRTM2]) of SRTM, all using gray matter cerebellum as the reference region, were applied to generate nondisplaceable binding potential (BPND) images. Results: Plasma-input Logan analysis (r(2) = 0.99; slope, 0.88) and spectral analysis (r(2) = 0.99, slope, 0.93) generated estimates of VT that correlated well with values obtained using nonlinear regression. BPND values generated using SRTM2 (r(2) = 0.83; slope, 0.95) and reference Logan analysis (r(2) = 0.88; slope, 1.01) correlated well with nonlinear regression based estimates. Conclusion: Both Logan analysis and spectral analysis can be used to obtain quantitatively accurate VT images of F-18-DPA-714. In addition, SRTM2 and reference Logan analysis can provide accurate BPND images. These parametric images could be used for voxel-based comparisons.


Last updated on 2021-24-06 at 09:17