Refereed journal article or data article (A1)
Changes in total and unbound concentrations of sufentanil during target controlled infusion for cardiac surgery with cardiopulmonary bypass
List of Authors: Jeleazcov C, Saari TI, Ihmsen H, Schuttler J, Fechner J
Publisher: OXFORD UNIV PRESS
Publication year: 2012
Journal: British Journal of Anaesthesia
Journal name in source: BRITISH JOURNAL OF ANAESTHESIA
Journal acronym: BRIT J ANAESTH
Volume number: 109
Issue number: 5
Start page: 698
End page: 706
Number of pages: 9
ISSN: 0007-0912
DOI: http://dx.doi.org/10.1093/bja/aes253
Abstract
Neither total nor unbound sufentanil concentrations remained constant when performing a TCI with the Gepts model in coronary artery bypass surgery with CPB. A pharmacokinetic model derived from patients undergoing cardiac surgery with CPB might improve the performance of TCI in this population.
Neither total nor unbound sufentanil concentrations remained constant when performing a TCI with the Gepts model in coronary artery bypass surgery with CPB. A pharmacokinetic model derived from patients undergoing cardiac surgery with CPB might improve the performance of TCI in this population.