A1 Journal article – refereed
Long-Term Interrelationship between Brain Metabolism and Amyloid Deposition in Mild Cognitive Impairment




List of Authors: Kemppainen N, Joutsa J, Johansson J, Scheinin NM, Nagren K, Rokka J, Parkkola R, Rinne JO
Publisher: IOS PRESS
Publication year: 2015
Journal: Journal of Alzheimer's Disease
Journal name in source: JOURNAL OF ALZHEIMERS DISEASE
Journal acronym: J ALZHEIMERS DIS
Volume number: 48
Issue number: 1
Number of pages: 11
ISSN: 1387-2877

Abstract


The aim of this longitudinal positron emission tomography (PET) study was to evaluate the interrelationship between brain metabolism and amyloid accumulation during the disease process from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Nine MCI patients, who converted to AD between two and five years, and nine healthy subjects underwent [C-11]PIB and [F-18]FDG PET scans at baseline and at 5 years. [C-11]PIB uptake was clearly higher in MCI patients at baseline compared to controls and spread extensively to the cerebral cortex during the conversion to AD. [F-18]FDG uptake was reduced especially in the temporal-parietal regions in MCI compared to controls at baseline, and widely over the cortex at the 5-year follow-up. The reduction in metabolism during the follow-up was significant in the posterior brain regions. In addition, brain amyloid load was positively associated with metabolism in posterior brain regions in MCI, but not after conversion to AD. The results suggest that there are interactions between brain amyloid accumulation and metabolism during the AD process, including a possible compensatory upregulation of posterior brain metabolism in the early phase.


Last updated on 2019-21-08 at 21:23

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