Pauliina Kronqvist
PhD, Senior clinical lecturer

Adjunct Professor, Faculty of Medicine (Faculty of Medicine)
Clinical Lecturer, Institute of Biomedicine (Institute of Biomedicine)

paukro@utu.fi
+358 29 450 4531
+358 50 436 4099

Kiinamyllynkatu 10
Turku





Areas of expertise
pathology; biomarkers; cancer; breast cancer

Biography

I graduated as a licentiate of medicine from University of Turku in 1990. Already as a medical student I became passionately attracted in histopathology and microscopy. I started my specialization in clinical pathology soon after authorization as a clinical practitioner by the Finnish Medical Board in 1991. After finishing my specialist training, I have worked as a clinical pathologist in Turku University Hospital with special diagnostic responsibility in breast pathology. Along with my clinical practice I have been employed in University of Turku as senior clinical lecturer and researcher. My research deals with prognostic biomarkers in breast cancer. On several occasions, I have also been employed abroad as clinical pathologist, clinical lecturer and researcher eg. in the Institute of Molecular Pathology in University of Copenhagen, in Galway University College Hospital in Ireland, in Karolinska University Hospital, and in King Faisal Specialist Hospital and Research Centre in Riyad, Saudi-Arabia. I also have special responsibilities in Histology core facility and development of undergraduate education in the medical faculty of University of Turku.



Research

The scope of my research is breast carcinoma, particularly triple-negative breast cancer (TNBC) as the main challenge of breast cancer prognostication and treatment today. My research deals with regulation of cell proliferation in breast cancer, focusing particularly at the cell cycle checkpoint proceeding metaphase-anaphase transition. This transition is responsible for the most essential steps of cell division resulting in chromosome segregation. In the normal cell, genetic stability is tightly controlled at this checkpoint through positive and negative feed-back mechanisms. My research concentrates on one of these signaling pathways associated with Securin (PTTG1). My interest in Securin originates from our cDNA-gene chip experiments where, among 4000 cancer-related genes, PTTG1 was revealed with the most differential gene expression level between breast carcinomas and benign breast epithelium. Later, we have witnessed based on immunohistochemistry a significant prognostic value for PTTG1-overexpression in breast cancer and particularly in TNBC. Presently, we are testing and validating the prognostic impact of Securin in multiparametric models to evaluate its clinical applicability in breast cancer prognostication. Moreover, we are investigating the epigenetic regulation of Securin in in vivo and in vitro models.



Teaching

Medical teaching and supervision as well as developing pedagogical tools in medical undergraduate education is my passion. This enthusiasm originates from the inspiring educational atmospheres which I have experienced in University of Turku and in the various foreign universities where I have worked as a medical teacher in undergraduate and postgraduate programs. I am actively participating in evaluation and development of undergraduate medical education in University of Turku. Over the years, I have also systematically sought to improve my skills in education and my understanding of learning theories by taking several pedagogical courses in University of Turku. In 2012, I also completed a master’s degree in Adult of Education and immediately thereafter registered a doctoral project in the Faculty of education, University of Turku. My ongoing doctoral research is a follow-up study aiming at identifying the initial motives and personality traits of medical students which eventually enable work commitment in the health care professions.



Publications
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Formin Proteins FHOD1 and INF2 in Triple-Negative Breast Cancer: Association With Basal Markers and Functional Activities (2018) Vanina D Heuser, Naziha Mansuri, Jasper Mogg, Samu Kurki, Heli Repo, Pauliina Kronqvist, Olli Carpén, Maria Gardberg
(
A1 Journal article – refereed)

HSD17B1 expression induces inflammation-aided rupture of mammary gland myoepithelium (2018)
Endocrine-Related Cancer
Päivi Järvensivu, Taija Heinosalo, Janne Hakkarainen, Pauliina Kronqvist, Niina Saarinen, Matti Poutanen
(
A1 Journal article – refereed)

Proliferation-associated miRNAs-494, -205, -21 and -126 detected by in situ hybridization: expression and prognostic potential in breast carcinoma patients (2018)
Journal of Cancer Research and Clinical Oncology
Natalia Gurvits, Tuomo‑Artturi Autere, Heli Repo, Marjukka Nykänen, Teijo Kuopio, Pauliina Kronqvist, Kati Talvinen
(
A1 Journal article – refereed)

Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity (vol 1, pg 796, 2017) (2018) Tanaka N, Kanatani S, Tomer R, Sahlgren C, Kronqvist P, Kaczynska D, Louhivuori L, Kis L, Lindh C, Mitura P, Stepulak A, Corvigno S, Hartman J, Micke P, Mezheyeuski A, Strell C, Carlson JW, Moro CF, Dahlstrand H, Ostman A, Matsumoto K, Wiklund P, Oya M, Miyakawa A, Deisseroth K, Uhlen P
(
O2 Other)

Breast cancer in neurofibromatosis type 1: overrepresentation of unfavourable prognostic factors (2017)
British Journal of Cancer
Uusitalo E, Kallionpää RA, Kurki S, Rantanen M, Pitkäniemi J, Kronqvist P, Härkönen P, Huovinen R, Carpen O, Pöyhönen M, Peltonen S, Peltonen J.
(
A1 Journal article – refereed)

PLA2G7 associates with hormone receptor negativity in clinical breast cancer samples and regulates epithelial-mesenchymal transition in cultured breast cancer cells (2017)
Journal of Pathology: Clinical Research
Lehtinen Laura, Vainio Paula, Wikman Harriet, Huhtala Heini, Mueller Volkmar, Kallioniemi Anne, Pantel Klaus, Kronqvist Pauliina, Kallioniemi Olli, Carpen Olli, Iljin Kristiina
(
A1 Journal article – refereed)

PTTG1-interacting protein (PTTG1IP/PBF) predicts breast cancer survival. (2017)
BMC Cancer
Repo, Gurvits, Löyttyniemi, Nykänen, Lintunen, Karra, Kurki, Kuopio, Talvinen, Söderström, Kronqvist
(
A1 Journal article – refereed)

PTTG1-interacting protein (PTTG1IP/PBF) predicts breast cancer survival (2017)
BMC Cancer
Repo H, Gurvits N, Loyttyniemi E, Nykanen M, Lintunen M, Karra H, Kurki S, Kuopio T, Talvinen K, Soderstrom M, Kronqvist P
(
A1 Journal article – refereed)

Separase is a marker for prognosis and mitotic activity in breast cancer (2017)
British Journal of Cancer
Gurvits N, Loyttyniemi E, Nykanen M, Kuopio T, Kronqvist P, Talvinen K
(
A1 Journal article – refereed)

Inhibiting Notch Activity in Breast Cancer Stem Cells by Glucose Functionalized Nanoparticles Carrying gamma-secretase Inhibitors (2016)
Molecular Therapy
Mamaeva V, Niemi R, Beck M, Ozliseli E, Desai D, Landor S, Gronroos T, Kronqvist P, Pettersen IKN, McCormack E, Rosenholm JM, Linden M, Sahlgren C
(
A1 Journal article – refereed)

L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling (2016)
Nature Communications
Jacquemet G, Baghirov H, Georgiadou M, Sihto H, Peuhu E, Cettour-Janet P, He T, Perälä M, Kronqvist P, Joensuu H, Ivaska J
(
A1 Journal article – refereed)

Prognostic implications of securin expression and sub-cellular localization in human breast cancer (2016)
Cellular Oncology
Gurvits N, Repo H, Löyttyniemi E, Nykänen M, Anttinen J, Kuopio T, Talvinen K, Kronqvist P
(
A1 Journal article – refereed)

Proteomic maps of breast cancer subtypes (2016)
Nature Communications
Tyanova S, Albrechtsen R, Kronqvist P, Cox J, Mann M, Geiger T
(
A1 Journal article – refereed)

Solunjakautumista säätelevät proteiinit securin, cdc20 ja cdc27 ennustavat kohonnutta rintasyöpäkuoleman riskiä (2016)
BestPractice Onkologia ja hematologia
Kronqvist P, Talvinen K
(
D1 Article in a trade journal)

The Expression of Cohesin Subunit SA2 Predicts Breast Cancer Survival (2016)
Applied Immunohistochemistry and Molecular Morphology
Heli Repo, Eliisa Löyttyniemi, Marjatta Nykänen, Lintunen Minnamaija, Henna Karra, Reino Pitkänen, Mirvamaaria Söderström, Teijo Kuopio, Pauliina Kronqvist
(
A1 Journal article – refereed)

Human breast cancer cells educate macrophages toward the M2 activation status. (2015)
Breast Cancer Research
Sofia Sousa, Régis Brion, Minnamaija Lintunen, Pauliina Kronqvist, Jouko Sandholm, Jukka Mönkkönen, Heikki Joensuu, Dominique Heymann, Jorma Määttä
(
A1 Journal article – refereed)

Cdc20 and securin overexpression predict short-term breast cancer survival (2014)
British Journal of Cancer
Karra H, Repo H, Ahonen I, Löyttyniemi E, Pitkänen R, Lintunen M, Kuopio T, Söderström M, Kronqvist P
(
A1 Journal article – refereed)

Hypoxia, blood flow and metabolism in squamous-cell carcinoma of the head and neck: correlations between multiple immunohistochemical parameters and PET (2014)
BMC Cancer
Grönroos TJ, Lehtiö K, Söderström KO, Kronqvist P, Laine J, Eskola O, Viljanen T, Grénman R, Solin O, Minn H
(
A1 Journal article – refereed)

ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins (2013)
Biochemical Journal
Frohlich C, Klitgaard M, Noer JB, Kotzsch A, Nehammer C, Kronqvist P, Berthelsen J, Blobel C, Kveiborg M, Albrechtsen R, Wewer UM
(
A1 Journal article – refereed)

Histological knowledge as a predictor of medical students' performance in diagnostic pathology (2013)
Anatomical Sciences Education
Nivala Markus, Lehtinen Erno, Helle Laura, Kronqvist Pauliina, Paranko Jorma, Säljö Roger
(
A1 Journal article – refereed)


Last updated on 2019-22-08 at 02:19