Nafis Rahman
MD, PhD

Adjunct Professor, Faculty of Medicine (Faculty of Medicine)
Clinical Lecturer, Institute of Biomedicine (Institute of Biomedicine)

nafrah@utu.fi
+358 29 450 4637
+358 50 477 3022

Kiinamyllynkatu 10
Turku





Areas of expertise
endocrine-related cancer; gonadotropins; hypothalamus-pituitary-gonadal axis; ardenocortical tumours; novel treatment strategies

Biography

Docent of Physiology, University of Turku, Turku, Finland (2005)  & Docent of Medicine, Medical University of Bialystok, Poland (2016); Doctor of Medical Sciences (Ph.D.), Medical University of Lodz, Poland  (1995); Specialization in Obstetrics & Gynecology, Medical University of Lodz, Poland  (1995); Licentiate in Medicine, Medical University of Lodz, Poland  (1991)

Working at the University of Turku: from 1996 - 

Postdoctoral training: Prof Ilpo Huhtaniemi group 1996 - 1998

Visiting professorships  Current: Medical University of Bialystok, Bialystok, Poland; Former: FIU College of Medicine, Miami, FL, USA

Editor in chief from 2016 https://www.journals.elsevier.com/reproductive-biology/



Research

Our study the underlying molecular mechanisms of hormonally regulated cancers (i.e. prostate, ovarian, testicular and adrenocortical), search for their novel biomarkers and treatment. We recently tested the potential of tumor specific zona pellucida antigen-3 immunization to enhance therapeutic effects in several hormonally regulated cancers. We have used successfully conjugated lytic peptides to eradicate only cancer cells through their specific gonadotropin receptors (such as lhcgr). We use transgenic murine endocrine cancer metastatic disease models and immortalized cell lines to test the feasibility of novel treatment strategies starting at cellular, in vivo in TG mice and finally aim for human clinical trials. 



Teaching

Teach at the University of Turku, Faculty of Medicine, medical curriculum students: Physiology, Endocrinology, reproductive Endocrinology; Reproductive Biology courses

Received the teacher of the year award (Vuoden Opettaja) in 2005 from the Student Union & Rector of the University of Turku.



Publications
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Extragonadal FSHR Expression and Function – Is It Real? (2019)
Frontiers in Endocrinology
Chrusciel Marcin, Ponikwicka-Tyszko Donata, Wolczynski Slawomir, Huhtaniemi Ilpo, Rahman Nafis A.
(
A2 Review article in a scientific journal)

GnRH antagonist treatment of malignant adrenocortical tumors (2019)
Endocrine-Related Cancer
Doroszko M, Chrusciel M, Stelmaszewska J, Slezak T, Anisimowicz S, Plöckinger U, Quinkler M, Bonomi M, Wolczynski S, Huhtaniemi I, Toppari J, Rahman NA
(
A1 Journal article – refereed)

Constitutively active follicle-stimulating hormone receptor enables androgen-independent spermatogenesis (2018)
Journal of Clinical Investigation
Oduwole OO, Peltoketo H, Poliandri A, Vengadabady L, Chrusciel M, Doroszko M, Samanta L, Owen L, Keevil B, Rahman NA, Huhtaniemi IT
(
A1 Journal article – refereed)

Functional Characterization of MicroRNA-27a-3p Expression in Human Polycystic Ovary Syndrome (2018)
Endocrinology
Wang, Sun, Xu, Chrusciel, Gao, Bazert, Stelmaszewska, Xu, Zhang, Pawelczyk, Sun, Tsang, Rahman, Wolczynski, Li
(
A1 Journal article – refereed)

Decidualization of the canine uterus: from early until late gestational in vivo morphological observations, and functional characterization of immortalized canine uterine stromal cell lines (2017)
Reproduction in Domestic Animals
Graubner FR, Reichler IM, Rahman NA, Payan-Carreira R, Boos A, Kowalewski MP
(
A1 Journal article – refereed)

Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX-Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model (2017)
Cellular Physiology and Biochemistry
Zareba I, Surazynski A, Chrusciel M, Miltyk W, Doroszko M, Rahman N, Palka J
(
A1 Journal article – refereed)

Functional Implications of LH/hCG Receptors in Pregnancy-Induced Cushing Syndrome (2017) Ursula Plöckinger, Marcin Chrusciel, Milena Doroszko, Wolfgang Saeger, Oliver Blankenstein, Katharina Weizsäcker, Matthias Kroiss, Kathrin Hauptmann, Cornelia Radke, Alexander Pöllinger, Nikolaus Tiling, Thomas Steinmüller, Ilpo Huhtaniemi, Marcus Quinkler, Jerome Bertherat, André Lacroix, Nafis Rahman
(
A1 Journal article – refereed)

Luteinizing hormone and GATA4 action in the adrenocortical tumorigenesis of gonadectomized female mice (2017)
Cellular Physiology and Biochemistry
Doroszko M., Chrusciel M., Stelmaszewska J., Slezak T., Rivero-Müller A., Padzik A., Anisimowicz S., Wolczynski S., Huhtaniemi I., Toppari J., Rahman N.A.
(
A1 Journal article – refereed)

Novel genes involved in pathophysiology of gonadotropin-dependent adrenal tumors in mice (2017)
Molecular and Cellular Endocrinology
Doroszko M, Chrusciel M, Belling K, Vuorenoja S, Dalgaard M, Leffers H, Nielsen HB, Huhtaniemi I, Toppari J, Rahman NA
(
A1 Journal article – refereed)

Zika virus infection-do they also endanger male fertility? (2017)
Science China Life Sciences
Rahman NA, Huhtaniemi I
(
B1 Journal article)

Functional Expression of FSH Receptor in Endometriotic Lesions (2016)
Journal of Clinical Endocrinology and Metabolism
Ponikwicka-Tyszko D, Chrusciel M, Stelmaszewska J, Bernaczyk P, Sztachelska M, Sidorkiewicz I, Doroszko M, Tomaszewski J, Tapanainen JS, Huhtaniemi I, Wolczynski S, Rahman NA
(
A1 Journal article – refereed)

Revisiting the expression and function of follicle-stimulation hormone receptor in human umbilical vein endothelial cells (2016)
Scientific Reports
Stelmaszewska J, Chrusciel M, Doroszko M, Åkerfelt M, Ponikwicka-Tyszko D, Nees M, Frentsch M, Li X, Kero J, Huhtaniemi I, Wolczynski S, Rahman NA.
(
A1 Journal article – refereed)

Distinct Testicular Steroidogenic Response Mechanisms Between Neonatal and Adult Heat-Acclimated Male Rats (2015)
Cellular Physiology and Biochemistry
Kurowicka B, Chrusciel M, Zmijewska A, Doroszko M, Kotwica G, Rahman NA
(
A1 Journal article – refereed)

Dysfunction of PSA-specific CD8(+) T cells in prostate cancer patients correlates with CD38 and Tim-3 expression (2015)
Cancer Immunology, Immunotherapy
Japp AS, Kursunel MA, Meier S, Malzer JN, Li XD, Rahman NA, Jekabsons W, Krause H, Magheli A, Klopf C, Thiel A, Frentsch M
(
A1 Journal article – refereed)

From the New Editor-in-Chief (2015)
Reproductive Biology
Nafis A. Rahman
(
B1 Journal article)

Functional consequences of knocking down porcine prostaglandin synthases in SK-6 swine kidney cell line (2015)
Reproductive Biology
Waclawik A, Rivero-Muller A, Rahman NA, Ziecik AJ
(
A1 Journal article – refereed)

Oestrogen action and male fertility: experimental and clinical findings (2015)
Cellular and Molecular Life Sciences
Li XD, Li HW, Jia LN, Li XR, Rahman N
(
A2 Review article in a scientific journal)

Estrogen promotes Leydig cell engulfment by macrophages in male infertility (2014)
Journal of Clinical Investigation
Yu W., Zheng H., Lin W., Tajima A., Zhang Y., Zhang X., Zhang H., Wu J., Han D., Rahman N., Korach K., Gao G., Inoue I., Li X.
(
A1 Journal article – refereed)

International symposium on "Animal models for human health" Preface (2014)
Reproductive Biology
Ziecik A, Jana B, Rahman NA
(
B1 Journal article)

Transgenic mice expressing inhibin alpha-subunit promoter (inh alpha)/Simian Virus 40 T-antigen (Tag) transgene as a model for the therapy of granulosa cell-derived ovarian cancer (2014)
Reproductive Biology
Chrusciel M, Doroszko M, Stelmaszewska J, Li XD, Ziecik AJ, Coelingh-Bennink HJT, Huhtaniemi I, Rahman NA
(
A2 Review article in a scientific journal)


Last updated on 2019-24-08 at 02:20