Daniel Laajala


Postdoctoral Researcher, Applied Mathematics (Department of Mathematics and Statistics)

teelaa@utu.fi
+358 29 450 3805
Vesilinnantie 5
Turku





Publications
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Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy (2019)
Nature Communications
Haikala HM, Anttila JM, Marques E, Raatikainen T, Ilander M, Hakanen H, Ala-Hongisto H, Savelius M, Balboa D, Von Eyss B, Eskelinen V, Munne P, Nieminen AI, Otonkoski T, Schuler J, Laajala TD, Aittokallio T, Sihto H, Mattson J, Heikkila P, Leidenius M, Joensuu H, Mustjoki S, Kovanen P, Eilers M, Leverson JD, Klefstrom J, Klefstrom J
(
A1 Journal article – refereed)

Antiandrogens Reduce Intratumoral Androgen Concentrations and Induce Androgen Receptor Expression in Castration-Resistant Prostate Cancer Xenografts (2018)
American Journal of Pathology
Scientific Reports
Knuuttila M, Mehmood A, Huhtaniemi R, Yatkin E, Häkkinen MR, Oksala R, Laajala TD, Ryberg H, Handelsman DJ, Aittokallio T, Auriola S, Ohlsson C, Laiho A, Elo LL, Sipilä P, Mäkelä SI, Poutanen M
(
A1 Journal article – refereed)

ePCR: an R-package for survival and time-to-event prediction in advanced prostate cancer, applied to real-world patient cohorts (2018)
Bioinformatics
Laajala TD, Murtojärvi M, Virkki A, Aittokallio T
(
A1 Journal article – refereed)

PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells (2018)
Science Translational Medicine
Scientific Reports
Otto Kauko, Caitlin M. O’Connor, Evgeny Kulesskiy, Jaya Sangodkar, Anna Aakula, Sudeh Izadmehr, Laxman Yetukuri, Bhagwan Yadav, Artur Padzik, Teemu Daniel Laajala, Pekka Haapaniemi, Majid Momeny, Taru Varila, Michael Ohlmeyer, Tero Aittokallio, Krister Wennerberg, Goutham Narla, Jukka Westermarck
(
A1 Journal article – refereed)

Secreted frizzled-related protein 2 (SFRP2) expression promotes lesion proliferation via canonical WNT signaling and indicates lesion borders in extraovarian endometriosis (2018)
Human Reproduction
Heinosalo T, Gabriel M, Kallio L, Adhikari P, Huhtinen K, Laajala TD, Kaikkonen E, Mehmood A, Suvitie P, Kujari H, Aittokallio T, Perheentupa A, Poutanen M
(
A1 Journal article – refereed)

Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, ismodifiable, and associates with future cardiovascular deaths (2018)
European Heart Journal
Ruuth M, Nguyen SD, Vihervaara T, Hilvo M, Laajala TD, Kondadi PK, Gistera A, Lahteenmaki H, Kittila T, Huusko J, Uusitupa M, Schwab U, Savolainen MJ, Sinisalo J, Lokki ML, Nieminen MS, Jula A, Perola M, Yla-Herttula S, Rudel L, Oorni A, Baumann M, Baruch A, Laaksonen R, Ketelhuth DFJ, Aittokallio T, Jauhiainen M, Kakela R, Boren J, Williams KJ, Kovanen PT, Oorni K
(
A1 Journal article – refereed)

Orphan G protein-coupled receptor GPRC5A modulates integrin β1-mediated epithelial cell adhesion (2017)
Cell Adhesion and Migration
Daria R. Bulanova, Yevhen A. Akimov, Anne Rokka, Teemu D. Laajala, Tero Aittokallio, Petri Kouvonen, Teijo Pellinen, Sergey G. Kuznetsov
(
A1 Journal article – refereed)

Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: development of a prognostic model through a crowdsourced challenge with open clinical trial data (2017)
Lancet Oncology
Cancer Research
Guinney J, Wang T, Laajala TD, Winner KK, Bare JC, Neto EC, Khan SA, Peddinti G, Airola A, Pahikkala T, Mirtti T, Yu T, Bot BM, Shen L, Abdallah K, Norman T, Friend S, Stolovitzky G, Soule H, Sweeney CJ, Ryan CJ, Scher HI, Sartor O, Xie Y, Aittokallio T, Zhou FL, Costello JC, and the Prostate Cancer Challenge DREAM Community
(
A1 Journal article – refereed)

CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection (2016)
PLoS ONE
Côme C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimentel JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Chen Z, Lahesmaa R, Westermarck J
(
A1 Journal article – refereed)

Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse (2016)
Journal of Proteomics
Anni P. Vehmas, Marion Adam, Teemu D. Laajala, Gabi Kastenmüller, Cornelia Prehn, Jan Rozman, Claes Ohlsson, Helmut Fuchs, Martin Hrabě de Angelis, Valérie Gailus-Durner, Laura L. Elo, Tero Aittokallio, Jerzy Adamski, Garry Corthals, Matti Poutanen, Leena Strauss
(
A1 Journal article – refereed)

Longitudinal modeling of ultrasensitive and traditional prostate-specific antigen and prediction of biochemical recurrence after radical prostatectomy (2016)
Laajala TD, Seikkula H, Sadat FS, Mirtti T, Boström PJ, Elo LL.
(
A1 Journal article – refereed)

Optimized design and analysis of preclinical intervention studies in vivo (2016)
Scientific Reports
Laajala TD, Jumppanen M, Huhtaniemi R, Fey V, Kaur A, Knuuttila M, Aho E, Oksala R, Westermarck J, Mäkelä S, Poutanen M*, Aittokallio T*A1 Journal article – refereed

2016
Molecular and Cellular Endocrinology
Bjorkgren I, Alvarez L, Blank N, Balbach M, Turunen H, Laajala TD, Toivanen J, Krutskikh A, Wahlberg N, Huhtaniemi I, Poutanen M, Wachten D, Sipila P
(
A1 Journal article – refereed)

The Hydroxysteroid (17 beta) Dehydrogenase Family Gene HSD17B12 Is Involved in the Prostaglandin Synthesis Pathway, the Ovarian Function, and Regulation of Fertility (2016)
Endocrinology
Kemilainen H, Adam M, Maki-Jouppila J, Damdimopoulou P, Damdimopoulos AE, Kere J, Hovatta O, Laajala TD, Aittokallio T, Adamski J, Ryberg H, Ohlsson C, Strauss L, Poutanen M
(
A1 Journal article – refereed)

Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling (2015)
Otto Kauko, Teemu Daniel Laajala, Mikael Jumppanen, Petteri Hintsanen, Veronika Suni, Pekka Haapaniemi, Garry Corthals, Tero Aittokallio, Jukka Westermarck, Susumu Y. Imanishi
(
A1 Journal article – refereed)

Protein phosphatase 2A activity is a major determinant of therapy response in cancer cells (2015)
Cancer Research
Kauko O, Imanishi S, Kaur A, Laajala D, Kulesskiy E, Jumppanen M, Corthals G, Aittokallio T, Wennerberg K, Westermarck J
(
O2 Other)

Castration induces up-regulation of intratumoral androgen biosynthesis and androgen receptor expression in an orthotopic VCaP human prostate cancer xenograft model (2014)
American Journal of Pathology
Matias Knuuttila, Emrah Yatkin, Jenny Kallio, Saija Savolainen, Teemu D. Laajala, Tero Aittokallio, Riikka Oksala, Merja Häkkinen, Pekka Keski-Rahkonen, Seppo Auriola, Matti Poutanen, Sari Mäkelä
(
A1 Journal article – refereed)

Castration induces upregulation of intratumoral androgen biosynthesis and androgen receptor expression in orthotopic VCaP human prostate cancer xenograft model (2014)
Matias Knuuttila, Emrah Yatkin, Jenny Kallio, Saija Savolainen, Teemu Daniel Laajala, Tero Aittokallio, Riikka Oksala, Merja Häkkinen, Pekka Keski-Rahkonen, Seppo Auriola, Matti Poutanen, Sari Mäkelä
(
O2 Other)

Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility. (2014)
Diabetes
Kallionpää Henna, Elo Laura, Laajala Essi, Mykkänen Juha, Ricaño-Ponce Isis, Vaarma Matti, Laajala Teemu Daniel, Hyöty Heikki, Ilonen Jorma, Veijola Riitta, Simell Tuula, Wijmenga Cisca, Knip Mikael, Lähdesmäki Harri, Simell Olli, Lahesmaa RiittaA1 Journal article – refereed


Last updated on 2019-16-07 at 02:22