Hannu Järveläinen
Professor

Professor, Department of Clinical Medicine (Department of Clinical Medicine)

hanjar@utu.fi
+358 29 450 4629
+358 46 922 9617

Kiinamyllynkatu 10
Turku





Areas of expertise
extracellular matrix; proteoglycans; decorin; hyaluronan, vascular biology, cancer biology, diabetes, biobank

Research

The extracellular matrix (ECM) consists of numerous macromolecules that
can be classified into collagens, elastin, and microfibrillar proteins,
proteoglycans including hyaluronan, and noncollagenous glycoproteins. 
Together they form a complex, three-dimensional network among the cells
of different tissues in an organ-specific manner. In addition to being
necessary structural components, ECM macromolecules exhibit important
functional roles in the control of key cellular events such as adhesion,
migration, proliferation, differentiation, and survival. Any structural
inherited or acquired defect and/or metabolic disturbance in the ECM
macromolecules may cause cellular and tissue alterations that can lead
to the development or progression of disease. Consequently, ECM
macromolecules are important targets for pharmacotherapy. Our interest
has been for a long time to study the role of matrix proteoglycans (PGs)
including hyaluronan in vascular biology. We have particularly focused
on the involvement of a small PG decorin with  atherogenesis and
angiogenesis. Lately we have also examined the role of decorin in
tumourigenesis. Our ultimate goal is to develop decorin-based therapies
to prevent luminal narrowing of arteries, to inhibit pathological
angiogenesis and to restrict tumour growth and metastasis.



Publications
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Decorin Expression and Oncosuppression in Human Embryonic Carcinomas (2019)
Archives of Clinical and Medical Case Reports
Annele Sainio, Mirka Pennanen, Jukka Laine, Riikka Lund, Mirva Söderström, Teijo Kuopio, Hannu Järveläinen
(
A1 Journal article – refereed)

Decorin Expression in Human Vulva Carcinoma: Oncosuppressive Effect of Decorin cDNA Transduction on Carcinoma Cells (2019)
Journal of Histochemistry and Cytochemistry
Marie C. Nyman, Anne B. Jokilammi, Pia C. Boström, Samu H. Kurki, Annele O. Sainio, Seija E. Grenman, Katri J. Orte, Sakari H. Hietanen, Klaus Elenius, Hannu T. Järveläinen
(
A1 Journal article – refereed)

A novel double nucleotide variant in the ferritin-L iron-responsive element in a Finnish patient with hereditary hyperferritinaemia-cataract syndrome (2018)
Acta Ophthalmologica
Roosa-Maria Mattila, Annele Sainio, Marketta Järveläinen, Juha Pursiheimo, Hannu Järveläinen
(
A1 Journal article – refereed)

Decorin-mediated oncosuppression – a potential future adjuvant therapy for human epithelial cancers (2018)
British Journal of Pharmacology
Annele Orvokki Sainio, Hannu Tapio Järveläinen
(
A2 Review article in a scientific journal)

Extracellular Matrix Macromolecules as Potential Targets of Cardiovascular Pharmacotherapy (2018) Vascular Pharmacology: Cytoskeleton and Extracellular Matrix Sainio A, Järveläinen H
(
B2 Book chapter)

Uusi täsmälääkeryhmä näköpiirissä tyypin 2 diabetekseen (2018)
Lääkärilehti
Hannu Järveläinen
(
D1 Article in a trade journal)

Alaraajojen verenkierron tutkiminen (2017) Jalkaterveys Hannu Järveläinen
(
D2 Article in a professional research book)

Diabeetikon jalkaongelmat: syntyy vaikuttavat tekijät, yleisyys ja kustannukset (2017) Jalkaterveys Hannu Järveläinen
(
D2 Article in a professional research book)

Diabeetikon jalkojenhoidon seuranta ja omahoidon ohjaus (2017) Jalkaterveys Anna-Leena Tapio, Hannu Järveläinen,
(
D2 Article in a professional research book)

Human Metaplastic Breast Carcinoma and Decorin (2017) Boström P, Sainio A, Eigėlienė N, Jokilammi A, Elenius K, Koskivuo I, Järveläinen H
(
A1 Journal article – refereed)

Kansallisaarre - kokemuksia Auria-biopankista (2017)
Diabetes ja lääkäri
Kurki S, Salminen-Mankonen H, Järveläinen H
(
D1 Article in a trade journal)

Suurentunut ferritiinipitoisuus - hämärtääkö näköä? (2017)
Duodecim
Roosa-Maria Mattila, Noora Wegelius, Annele Sainio, Marketta Järveläinen, Juha Pursiheimo, Hannu Järveläinen
(
D1 Article in a trade journal)

Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells (2016)
Scientific Reports
Konki M, Pasumarthy K, Malonzo M, Sainio A, Valensisi C, Soderstrom M, Emani MR, Stubb A, Narva E, Ghimire B, Laiho A, Jarvelainen H, Lahesmaa R, Lahdesmaki H, Hawkins RD, Lund RJ
(
A1 Journal article – refereed)

Onko DPP-4:n estäjien suosio diabeteksen hoidossa perusteltua? (2016)
Lääkärilehti
Hannu Järveläinen
(
D1 Article in a trade journal)

Uusi glukoosin omaseurantalaite – käytännön kokemuksia (2016)
Lääkärilehti
Rönnemaa T, Järveläinen H, Nousiainen E, Tuomi T, Ahtiainen T, Risku S, Soinio M, Lahtela J
(
D1 Article in a trade journal)

Decorin in Human Colon Cancer: Localization In Vivo and Effect on Cancer Cell Behavior In Vitro. (2015)
Journal of Histochemistry and Cytochemistry
Nyman MC, Sainio AO, Pennanen MM, Lund RJ, Vuorikoski S, Sundström JT, Järveläinen HT
(
A1 Journal article – refereed)

Pivotal role for decorin in angiogenesis (2015)
Matrix Biology
Järveläinen H, Sainio A, Wight TN
(
A2 Review article in a scientific journal)

Extracellular matrix macromolecules: potential tools and targets in cancer gene therapy. (2014)
Molecular and Cellular Therapies
Sainio A, Järveläinen H
(
A2 Review article in a scientific journal)

HbA1c auttaa diabeteksen hoidossa ja seurannassa (2014)
Moodi
Järveläinen Hannu
(
D1 Article in a trade journal)

Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Cancer (2014)
European Medical Journal Urology
Syvänen K, Järveläinen H, Taimen P, Laato M, Boström PJ
(
A1 Journal article – refereed)


Last updated on 2019-26-08 at 02:21