Harry Scheinin
MD
Anesthesiology and Intensive Care harry.scheinin@utu.fi ORCID identifier: https://orcid.org/0000-0002-1171-3511 |
Anesthesiology; Clinical Pharmacology; Neuroscience; Positron Emission Tomography
Harry Scheinin leads the Anesthesia Mechanisms Research Group at the University of Turku, Finland, and has studied the human neurobiology of anesthetic agents for 20 years. He has collaborated with Professor Antti Revonsuo since 2005.
We try to explore the neural correlates of human consciousness using, e.g., modern imaging methods. We aim to separate consciousness from responsiveness, connectedness from disconnection and to compare unconsciousness of physiological sleep with that induced by anesthetic agents. Finding new tools for the distinction of consciousness, connectedness and responsiveness would be groundbreaking and could represent a major leap forward in understanding human consciousness. The results could also help in developing new EEG-based methods to objectively measure consciousness and the depth of general anesthesia.
- Comparison of the prognostic value of early-phase proton magnetic resonance spectroscopy and diffusion tensor imaging with serum neuron-specific enolase at 72 h in comatose survivors of out-of-hospital cardiac arrest-a substudy of the XeHypotheca trial (2023)
- Neuroradiology
(Refereed journal article or data article (A1)) - Decreased Thalamic Activity Is a Correlate for Disconnectedness during Anesthesia with Propofol, Dexmedetomidine and Sevoflurane But Not S-Ketamine (2023)
- Journal of Neuroscience
(Refereed journal article or data article (A1)) - Effects of dexmedetomidine on pharyngeal swallowing and esophageal motility-A double-blind randomized cross-over study in healthy volunteers (2023)
- Neurogastroenterology and Motility
(Refereed journal article or data article (A1)) - Response to Letter to the Editor (2023)
- Neurogastroenterology and Motility
(Article or data-article in scientific journal (B1)) - Subjective experiences during dexmedetomidine- or propofol-induced unresponsiveness and non-rapid eye movement sleep in healthy male subjects (2023)
- British Journal of Anaesthesia
(Refereed journal article or data article (A1)) - Circulating oxylipin and bile acid profiles of dexmedetomidine, propofol, sevoflurane, and S-ketamine : a randomised controlled trial using tandem mass spectrometry (2022)
- BJA Open
(Refereed journal article or data article (A1)) - Effects of dexmedetomidine, propofol, sevoflurane and S-ketamine on the human metabolome: A randomised trial using nuclear magnetic resonance spectroscopy (2022)
- European Journal of Anaesthesiology
(Refereed journal article or data article (A1)) - Anestesiologian ja tehohoidon kliinisen tutkimuksen perusteita (2021) Anestesiologia, teho-, ensi- ja kivunhoito Scheinin Harry, Uusaro Ari
(Article in a professional research book (D2)) - Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest—A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial (2021)
- Critical Care Explorations
(Refereed journal article or data article (A1)) - Foundations of human consciousness: Imaging the twilight zone (2021)
- Journal of Neuroscience
(Refereed journal article or data article (A1)) - Inhalaatioanestesia ja laskimoanestesia (2021) Anestesiologia, teho-, ensi- ja kivunhoito Scheinin Harry
(Article in a professional research book (D2)) - Laskimoanestesia-aineet ja sedaatiolääkkeet (2021) Anestesiologia, teho-, ensi- ja kivunhoito Scheinin Harry, Valtonen Mika
(Article in a professional research book (D2)) - On no man’s land: Subjective experiences during unresponsive and responsive sedative states induced by four different anesthetic agents (2021)
- Consciousness and Cognition
(Refereed journal article or data article (A1)) - Seasonal variation in the brain μ-opioid receptor availability (2021)
- Journal of Neuroscience
(Refereed journal article or data article (A1)) - Aivojen vapaiden myy-opioidireseptorien määrä vaihtelee ihmisten välillä (2020)
- Duodecim
(Article in trade journal or blog post (D1)) - Alpha band frontal connectivity is a state-specific electroencephalographic correlate of unresponsiveness during exposure to dexmedetomidine and propofol (2020)
- British Journal of Anaesthesia
(Refereed journal article or data article (A1)) - Interindividual variability and lateralization of mu-opioid receptors in the human brain (2020)
- NeuroImage
(Refereed journal article or data article (A1)) - Single-subject analysis of N400 event-related potential component with five different methods (2019)
- International Journal of Psychophysiology
(Refereed journal article or data article (A1)) - Suomen Anestesiologiyhdistyksen suositus anestesiatoiminnan järjestämisestä (2019)
- Finnanest
(Article in trade journal or blog post (D1)) - The influence of dexmedetomidine and propofol on circulating cytokine levels in healthy subjects (2019)
- BMC Anesthesiology
(Refereed journal article or data article (A1))