Harry Scheinin
MD

Adjunct Professor
Anesthesiology and Intensive Care
harry.scheinin@utu.fi






Areas of expertise
Anesthesiology; Clinical Pharmacology; Neuroscience; Positron Emission Tomography

Biography

Harry Scheinin leads the Anesthesia Mechanisms Research Group at the University of Turku, Finland, and has studied the human neurobiology of anesthetic agents for 20 years. He has collaborated with Professor Antti Revonsuo since 2005.



Research

We try to explore the neural correlates of human consciousness using, e.g., modern imaging methods. We aim to separate consciousness from responsiveness, connectedness from disconnection and to compare unconsciousness of physiological sleep with that induced by anesthetic agents. Finding new tools for the distinction of consciousness, connectedness and responsiveness would be groundbreaking and could represent a major leap forward in understanding human consciousness. The results could also help in developing new EEG-based methods to objectively measure consciousness and the depth of general anesthesia. 



Publications
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Alterations in heart rate variability in patients with peripheral arterial disease requiring surgical revascularization have limited association with postoperative major adverse cardiovascular and cerebrovascular events (2018)
PLoS ONE
Utriainen KT, Airaksinen JK, Polo OJ, Scheinin H, Laitio RM, Leino KA, Vahlberg TJ, Kuusela TA, Laitio TT
(
A1 Journal article – refereed)

Comparative effects of dexmedetomidine, propofol, sevoflurane, and S-ketamine on regional cerebral glucose metabolism in humans: a positron emission tomography study (2018)
British Journal of Anaesthesia
Laaksonen L., Kallioinen M., Långsjö J., Laitio T., Scheinin A., Scheinin J., Kaisti K., Maksimow A., Kallionpää R.E., Rajala V., Johansson J., Kantonen O., Nyman M., Sirén S., Valli K., Revonsuo A., Solin O., Vahlberg T., Alkire M., Scheinin H.
(
A1 Journal article – refereed)

Differentiating Drug-related and State-related Effects of Dexmedetomidine and Propofol on the Electroencephalogram (2018)
Anesthesiology
Scheinin A, Kallionpää RE, Li D, Kallioinen M, Kaisti K, Långsjö J, Maksimow A, Vahlberg T, Valli K, Mashour GA, Revonsuo A, Scheinin H
(
A1 Journal article – refereed)

Dreaming and awareness during dexmedetomidine- and propofol-induced unresponsiveness (2018)
British Journal of Anaesthesia
L. Radek, R.E. Kallionpää, M. Karvonen, A. Scheinin, A. Maksimow, J. Långsjö K. Kaisti, T. Vahlberg, A. Revonsuo, H. Scheinin, K. Valli
(
A1 Journal article – refereed)

Sleep apnoea is associated with major cardiac events in peripheral arterial disease (vol 43, pg 1652, 2014) (2018)
European Respiratory Journal
Utriainen KT, Airaksinen JK, Polo O, Laitio R, Pietila MJ, Scheinin H, Vahlberg T, Leino KA, Kentala ES, Jalonen JR, Hakovirta H, Parkkola R, Virtanen S, Laitio TT
(
O2 Other)

Spoken words are processed during dexmedetomidine-induced unresponsiveness (2018)
British Journal of Anaesthesia
Kallionpää R.E., Scheinin A., Kallionpää R.A., Sandman N., Kallioinen M., Laitio R., Laitio T., Kaskinoro K., Kuusela T., Revonsuo A., Scheinin H., Valli K.
(
A1 Journal article – refereed)

Using Positron Emission Tomography in Revealing the Mystery of General Anesthesia: Study Design Challenges and Opportunities (2018) Chemical and Biochemical Approaches for the Study of Anesthetic Function Part B Scheinin Harry, Alkire Emilee C., Scheinin Annalotta, Alkire Michael T., Kantonen Oskari, Långsjö Jaakko
(
B2 Book chapter)

Inhaled Xenon Attenuates Myocardial Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest The Xe-Hypotheca Trial (2017)
Journal of the American College of Cardiology
Olli Arola, Antti Saraste, Ruut Laitio, Juhani Airaksinen, Marja Hynninen, Minna Bäcklund, Emmi Ylikoski, Johanna Wennervirta, Mikko Pietilä, Risto O. Roine, Veli-Pekka Harjola, Jussi Niiranen, Kirsi Korpi, Marjut Varpula, Harry Scheinin, Mervyn Maze, Tero Vahlberg, Timo Laitio
(
A1 Journal article – refereed)

Detecting a dexmedetomidine-evoked reduction of noradrenaline release in the human brain with the α2C-adrenoceptor PET ligand [11C]ORM-13070 (2016)
Synapse
Lehto J, Scheinin A, Johansson J, Marjamäki P, Arponen E, Scheinin H, Scheinin M
(
A1 Journal article – refereed)

Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest A Randomized Clinical Trial (2016)
JAMA: Journal of the American Medical Association
Laitio R, Hynninen M, Arola O, Virtanen S, Parkkola R, Saunavaara J, Roine RO, Grönlund J, Ylikoski E, Wennervirta J, Bäcklund M, Silvasti P, Nukarinen E, Tiainen M, Saraste A, Pietilä M, Airaksinen J, Valanne L, Martola J, Silvennoinen H, Scheinin H, Harjola VP, Niiranen J, Korpi K, Varpula M, Inkinen O, Olkkola KT, Maze M, Vahlberg T, Laitio T
(
A1 Journal article – refereed)

Electroencephalogram reactivity to verbal command after dexmedetomidine, propofol and sevoflurane-induced unresponsiveness (2015)
Anaesthesia
K. Kaskinoro, A. Maksimow, S. Georgiadis, J. Långsjö, H. Scheinin, P. Karjalainen, S. K. Jääskeläinen
(
A1 Journal article – refereed)

Imaging of a2C-adrenoceptors in the living brain: a method to monitor noradrenaline release? (2015)
SpringerPlus
Scheinin M, Lehto J, Johansson J, Luoto P, Arponen E, Vuorilehto L, Scheinin H, Rouru J
(
O2 Other)

Intravenous ethanol increases dopamine release in the ventral striatum in humans: PET study using bolus-plus-infusion administration of [11C]raclopride (2015)
Journal of Cerebral Blood Flow and Metabolism
Sargo Aalto, Kimmo Ingman, Kati Alakurtti, Valtteri Kaasinen, Jussi Virkkala, Kjell Någren, Juha O Rinne, Harry Scheinin
(
A1 Journal article – refereed)

Sensitivity of [C-11]ORM-13070 to increased extracellular noradrenaline in the CNS - a PET study in human subjects (2015)
Psychopharmacology
Lehto J, Johansson J, Vuorilehto L, Luoto P, Arponen E, Scheinin H, Rouru J, Scheinin M
(
A1 Journal article – refereed)

Validation of [11C]ORM-13070 as a PET tracer for alpha2c-adrenoceptors in the human brain (2015)
Synapse
Jussi Lehto, Mika M. Hirvonen, Jarkko Johansson, Jukka Kemppainen, Pauliina Luoto, Tarja Naukkarinen, Vesa Oikonen, Eveliina Arponen, Juha Rouru, Jukka Sallinen, Harry Scheinin, Lauri Vuorilehto, Sjoerd J. Finnema, Christer Halldin, Juha O. Rinne, Mika Scheinin
(
A1 Journal article – refereed)

Voiko anestesian syvyyttä mitata aivosähkökäyrällä? (2015)
Duodecim
Arvi Yli-Hankala, Harry Scheinin
(
A1 Journal article – refereed)

Yleisanestesian mysteeri - mitä aivoissa tapahtuu, kun ihminen nukutetaan ja herätetään? (2015)
Tehohoito
Harry Scheinin
(
D1 Article in a trade journal)

Anestesiologian ja tehohoidon kliinisen tutkimuksen perusteita (2014) Anestesiologia ja tehohoito Harry Scheinin, Ari Uusaro
(
D2 Article in a professional research book)

Directional connectivity between frontal and posterior brain regions Is altered with increasing concentrations of propofol (2014)
PLoS ONE
Anu Maksimow, Minna Silfverhuth, Jaakko Långsjö, Kimmo Kaskinoro, Stefanos Georgiadis, Satu Jääskeläinen, Harry Scheinin
(
A1 Journal article – refereed)

Harnessing Anesthesia and Brain Imaging for the Study of Human Consciousness (2014)
Current Pharmaceutical Design
Langsjo Jaakko W., Revonsuo Antti, Scheinin Harry
(
A1 Journal article – refereed)


Last updated on 2018-10-09 at 21:11