Kristiina Heikinheimo
DDS, MS, PhD; Visiting Professor, King´s College London

Adjunct Professor, Faculty of Medicine (Faculty of Medicine)
University Lecturer, Institute of Dentistry (Institute of Dentistry)

kristiina.heikinheimo@utu.fi
+358 29 450 4478
+358 50 514 8329

Lemminkäisenkatu 2
Turku
Department of Oral and Maxillofacial Surgery Institute of Denti




Research

Overall description
During the past two decades the main research focus of the group has been to study roles played by growth factors and their receptors in odontogenic tumors and in cancers of salivary gland and of oral squamous cell origin. The working hypothesis is that some of the same molecules that regulate normal development are aberrated in these tumors. Therefore analyses of their putative tissues of origin e.g developing tooth, salivary gland and oral epithelia have been included. This comparative approach has contributed new results also to craniofacial developmental biology.

The group has a strong background in modern methods of molecular biology including in situ hybridization, Northern analysis and QRT-PCR. Recently genome-wide genomics including cDNA array, array-comparative genomic hybridization (aCGH), single nucleotide polymorphism (SNP) arrays and Next Generation and RNA Sequencing ( NGS and RNA-Seq) have been ulilized in search for aberrated genes and signaling pathways in the these tumors.

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Research objectives
The major aim of the group is to identify molecular-level changes in tumors of the head and neck to develop better diagnostic and prognostic tools to advance treatment modalities. Our group has produced several original findings on the molecular phenotype of head and neck tumors and will continue in the priority areas listed below.

Group's research strategy 2018-2020
The group will be engaged in the following projects in 2018-2020

• Emerging biomarkers and targeted treatments in odontogenic tumors.
• Mutation landscape of salivary gland tumors and novel targets for treatment.
These projects have gained approval by the ethical Committee of the Hospital District of Southwest Finland (1/11.3.2007).

Citations  2641
h-index 32
(12.12.2018)

Google Scholar Citations
http://scholar.google.com/citations?user=-NbTOZEAAAAJ



Publications

The Mutational Profile of Unicystic Ameloblastoma (2018)
Journal of Dental Research
Heikinheimo K, Huhtala JM, Thiel A, Kurppa KJ, Heikinheimo H, Kovac M, Kragelund C, Warfvinge G, Dawson H, Elenius K, Ristimäki A, Baumhoer D, Morgan PR
(
A1 Journal article – refereed)

Ameloblastoma (2017) WHO classification of head and neck tumours Vered M, Muller S, Heikinheimo K
(
D2 Article in a professional research book)

Periosteal fasciitis in a 7-year old girl: a diagnostic dilemma (2017)
International Journal of Oral and Maxillofacial Surgery
Lääveri M, Heikinheimo K, Baumhoer D, Slootweg PJ, Happonen RP
(
B1 Journal article)

Treatment with soluble activin type IIB-receptor improves bone mass and strength in a mouse model of Duchenne muscular dystrophy (2017)
BMC Musculoskeletal Disorders
Tero Puolakkainen, Hongqian Ma, Heikki Kainulainen, Arja Pasternack, Timo Rantalainen, Olli Ritvos, Kristiina Heikinheimo, Juha J. Hulmi, Riku Kiviranta
(
A1 Journal article – refereed)

Chondral ossification centers next to dental primordia in the human mandible: A study of the prenatal development ranging between 68 to 270 mm CRL (2016)
Annals of Anatomy
Radlanski Ralf J, Renz Herbert, Zimmermann Camilla A, Schuster Felix P, Voigt Alexander, Heikinheimo Kristiina
(
A1 Journal article – refereed)

Early Dental Epithelial Transcription Factors Distinguish Ameloblastoma from Keratocystic Odontogenic Tumor (2015)
Journal of Dental Research
K. Heikinheimo, K.J. Kurppa, A. Laiho, S. Peltonen, A. Berdal, A. Bouattour, B. Ruhin, J. Catón, I. Thesleff, I. Leivo, P.R. Morgan
(
A1 Journal article – refereed)

Novel Targets for the Treatment of Ameloblastoma (2015)
Journal of Dental Research
K. Heikinheimo, K.J. Kurppa, K. Elenius
(
A2 Review article in a scientific journal)

High frequency of BRAF V600E mutations in ameloblastoma (2014)
Journal of Pathology
Kari J Kurppa, Javier Catón, Peter R Morgan, Ari Ristimäki, Blandine Ruhin, Jari Kellokoski, Klaus Elenius, Kristiina Heikinheimo
(
A1 Journal article – refereed)

No sexual dimorphism in human prenatal metacarpal ratios (2014)
Early Human Development
Stefan Van Dongen, Frietson Galis, Clara Ten Broek, Kristiina Heikinheimo, Liliane C.D.Wijnaendts, Sofie Delena, Jessica Bots
(
A1 Journal article – refereed)

When right differs from left – Human limb directional asymmetry emerges during very early development (2014)
Laterality
Stefan Van Dongen, Frietson Galis, Clara Ten Broek, Kristiina Heikinheimo, Liliane C. D. Wijnaendts, Sofie Delen, Jessica Bots
(
A1 Journal article – refereed)

Cephalometric assessment of human fetal head specimens (2013)
Fortschritte der Kieferorthopädie / Journal of Orofacial Orthopedics
Radlanski RJ, Heikinheimo K, Gruda A
(
A1 Journal article – refereed)

Critical role for alpha v beta 6 integrin in enamel biomineralization (2013)
Journal of Cell Science
Mohazab L, Koivisto L, Jiang GQ, Kytomaki L, Haapasalo M, Owen GR, Wiebe C, Xie YS, Heikinheimo K, Yoshida T, Smith CE, Heino J, Hakkinen L, McKee MD, Larjava H
(
A1 Journal article – refereed)

Expression of the stem cell marker, SOX2, in ameloblastoma and dental epithelium (2013)
European Journal of Oral Sciences
Juuri E, Isaksson S, Jussila M, Heikinheimo K, Thesleff I
(
A1 Journal article – refereed)

Genomic profiles and CRTC1-MAML2 fusion distinguish different subtypes of mucoepidermoid carcinoma (2013)
Modern Pathology
Jee KJ, Persson M, Heikinheimo K, Passador-Santos F, Aro K, Knuutila S, Odell EW, Makitie A, Sundelin K, Stenman G, Leivo I
(
A1 Journal article – refereed)

Sox2 marks epithelial competence to generate teeth in mammals and reptiles (2013)
Development
Juuri E, Jussila M, Seidel K, Holmes S, Wu P, Richman J, Heikinheimo K, Chuong CM, Arnold K, Hochedlinger K, Klein O, Michon F, Thesleff I
(
A1 Journal article – refereed)

Analysis of cervical ribs in a series of human fetuses (2011)
Journal of Anatomy
Bots Jessica, Wijnaendts Liliane CD, Delen Sofie, Van Dongen Stefan, Heikinheimo Kristiina, Galis Frietson
(
A1 Journal article – refereed)

Compound Heterozygous Desmoplakin Mutations Result in a Phenotype with a Combination of Myocardial, Skin, Hair, and Enamel Abnormalities (2010)
Journal of Investigative Dermatology
Mahoney MG, Sadowski S, Brennan D, Pikander P, Saukko P, Wahl J, Aho H, Heikinheimo K, Bruckner-Tuderman L, Fertala A, Peltonen J, Uitto J, Peltonen S
(
A1 Journal article – refereed)

Effects of snuff extract on epithelial growth and differentiation in vitro (2004)
Oral Oncology
Merne M, Heikinheimo K, Saloniemi I, Syrjanen S
(
A1 Journal article – refereed)

CD44v6 in developing, dysplastic and malignant oral epithelia (2003)
Oral Oncology
Rautava J, Soukka T, Inki P, Leimola-Virtanen R, Saloniemi I, Happonen RP, Heikinheimo K
(
A1 Journal article – refereed)

Cell proliferation and chromosomal changes in human ameloblastoma (2002)
Cancer Genetics and Cytogenetics
Jaaskelainen K, Jee KJ, Leivo I, Saloniemi I, Knuutila S, Heikinheimo K
(
A1 Journal article – refereed)


Last updated on 2019-17-08 at 02:18