Natalia Battchikova
PhD, Adj. Prof.

Adjunct Professor, Department of Biology (Department of Biology)
Senior Research Fellow, Molecular Plant Biology (Department of Biochemistry)
Department of Biochemistry, Molecular Plant Biology laboratory
natbat@utu.fi
+358 29 450 4207
+358 50 441 3635

Tykistökatu 6
Turku
BioCity 6th floor elevator A
Office: 6115



Areas of expertise
Proteomics; phosphoproteomics; cyanobacteria; NDH-1 complex; genetic engineering; cyanobacterial transformation

Biography

Born in Moscow, USSR.

Graduated from the Lomonosov Moscow State University.

Post-graduate student in the Institute of
Molecular Biology of USSR Academy of Sciences.

Got a PhD degree accepted by the Higher Attestation Commission
under the USSR Council of Ministers.

At present: Adjunct Professor of Molecular Biology appointed by the University of Turku, Finland


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Research



CyanoPhosphoProteomics: A search for novel signaling and regulatory
pathways in cyanobacteria 

Research of photosynthetic organisms, with
its potential for development of a renewable and CO2-neutral energy system, has
become increasingly important in the last decade and attracted significant
attention of the society.  Cyanobacteria
are among the most important candidates for the efficient production of targeted chemicals and fuels because they can produce desirable compounds using only sunlight, water and inorganic nutrients.
The present project intends to reveal in cyanobacteria hidden pathways of
regulation and signaling which are based on Ser/Thr and Tyr protein
phosphorylation. The
aim of the research is to investigate cyanobacterial
phosphoproteins in order to i) discover novel protein phosphorylation sites,
ii) study dynamics of protein phosphorylation events in response to various
environmental stimuli, iii) assign links between phosphoproteins and
corresponding kinases, and iv) find out how the phosphorylation signal is
processed and reflected in intracellular changes. In order to stimulate various signaling pathways, cells
will be challenged by environmental stresses (light/darkness, carbon, nitrogen
and other nutrients limitations). Phosphoproteins will be examined using innovative quantitative and targeted
mass spectrometry, molecular biology and genetic engineering methods aiming to
get novel insights into a complicated network of the post-translational
regulation and signaling. Exploration of cyanobacterial phosphoproteomes will
significantly expand our knowledge of fundamental processes occurring in
blue-green alga, such as oxygenic photosynthesis, nitrogen fixation, CO2
uptake, hydrogen production, cell differentiation, etc., and will lead to novel
technological applications.



Teaching



Supervising of the PhD studies

Lectures:   


SYST1010, “Systems biology lectures”, three
lectures (“Proteomics I: Proteomes and proteomic approaches. Preparation of
samples for mass spectrometry analysis”; “Proteomics II: Basics in mass
spectrometry of peptides”, and “Proteomics III: Quantitative proteomics and
PTMs” (2014, 2015, 2016, 2017, 2018)


SYST
5044 (KABI 5044), “Introduction to Bioenergetics”, the lecture “Proteomics in
photosynthesis” (2015, 2016, 2017, 2018)


SYST1100,
“ Bioinformatics”, the lecture “"Biological databases" and practical
exercises “Acquaintance with NCBI" (2014, 2015, 2016)



Publications
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Global proteome response of Synechocystis 6803 to extreme copper environments applied to control the activity of the inducible petJ promoter (2019)
Journal of Applied Microbiology
Angeleri M., Muth-Pawlak D., Wilde A., Aro E-M., Battchikova N.
(
A1 Journal article – refereed)

The Cytochrome b(6)f Complex Is Not Involved in Cyanobacterial State Transitions (2019)
Plant Cell
Calzadilla PI, Zhan J, Setif P, Lemaire C, Solymosi D, Battchikova N, Wang Q, Kirilovsky D
(
A1 Journal article – refereed)

Interplay of SpkG kinase and the Slr0151 protein in the phosphorylation of ferredoxin 5 in Synechocystis sp strain PCC 6803 (2018)
FEBS Letters
Martina Angeleri, Anna Zorina, Eva-Mari Aro, Natalia Battchikova
(
A1 Journal article – refereed)

Proteomics of cyanobacteria: current horizons (2018)
Current Opinion in Biotechnology
Natalia Battchikova, Dorota Muth-Pawlak, Eva-Mari Aro
(
A2 Review article in a scientific journal)

Dissecting the Photoprotective Mechanism Encoded by the flv4-2 Operon: a Distinct Contribution of Sll0218 in Photosystem II Stabilization (2017)
Plant, Cell and Environment
Luca Bersanini, Yagut Allahverdiyeva, Natalia Battchikova, Steffen Heinz, Maija Lespinasse, Essi Ruohisto, Henna Mustila, Jörg Nickelsen, Imre Vass, Eva-Mari Aro
(
A1 Journal article – refereed)

Role of Type 2 NAD(P)H Dehydrogenase NdbC in Redox Regulation of Carbon Allocation in Synechocystis (2017)
Plant Physiology
Tuomas Huokko, Dorota Muth-Pawlak, Natalia Battchikova, Yagut Allahverdiyeva, Eva-Mari Aro
(
A1 Journal article – refereed)

Septal protein SepJ from the heterocyst-forming cyanobacterium Anabaena forms multimers and interacts with peptidoglycan (2017)
FEBS Open Bio
Félix Ramos-Leon, Vincente Mariscal, Natalia Battchikova, Aro Eva-Mari, Enrique Flores
(
A1 Journal article – refereed)

Calcium impacts carbon and nitrogen balance in the filamentous cyanobacterium Anabaena sp PCC 7120 (2016)
Journal of Experimental Botany
Walter J, Lynch F, Battchikova N, Aro EM, Gollan PJ
(
A1 Journal article – refereed)

Changes in Relative Thylakoid Protein Abundance Induced by Fluctuating Light in the Diatom Thalassiosira pseudonana (2016)
Journal of Proteome Research
Grouneva I, Muth-Pawlak D, Battchikova N, Aro EM
(
A1 Journal article – refereed)

Study of O-Phosphorylation Sites in Proteins Involved in Photosynthesis-Related Processes in Synechocystis sp Strain PCC 6803: Application of the SRM Approach (2016)
Journal of Proteome Research
Angeleri M, Muth-Pawlak D, Aro EM, Battchikova N
(
A1 Journal article – refereed)

The Flavodiiron Protein Flv3 Functions as a Homo-Oligomer During Stress Acclimation and is Distinct from the Flv1/Flv3 Hetero-Oligomer Specific to the O-2 Photoreduction Pathway (2016)
Plant and Cell Physiology
Henna Mustila, Pasi Paananen, Natalia Battchikova, Anita Santana-Sánchez, Dorota Muth-Pawlak,
Martin Hagemann, Eva-Mari Aro, Yagut Allahverdiyeva

(
A1 Journal article – refereed)

The NDH-1L-PSI Supercomplex Is Important for Efficient Cyclic Electron Transport in Cyanobacteria (2016)
Plant Physiology
Gao F, Zhao F, Chen L, Battchikova Natalia, Ran Z, Aro Eva-Mari, Ogawa T, Ma W
(
A1 Journal article – refereed)

Turning around the electron flow in an uptake hydrogenase. EPR spectroscopy and in vivo activity of a designed mutant in HupSL from Nostoc punctiforme (2016)
Energy and Environmental Science
Patrícia Raleiras, Namita Khanna, Hélder Miranda, Lívia S. Mészáros, Henning Krassen, Felix Ho, Natalia Battchikova, Eva-Mari Aro, Ann Magnuson, Peter Lindblad, Stenbjörn Styring
(
A1 Journal article – refereed)

Chlamydomonas Flavodiiron Proteins Facilitate Acclimation to Anoxia During Sulfur Deprivation (2015)
Plant and Cell Physiology
Jokel M, Kosourov S, Battchikova N, Tsygankov AA, Aro EM, Allahverdiyeva Y
(
A1 Journal article – refereed)

Draft Genome Sequence of Calothrix 336/3, novel H2 Producing Cyanobacterium Isolated from Finnish Lake – Draft genome Sequence of Calothrix 336/3 (2015) Janne Isojärvi, Sumathy Shunmugam, Kaarina Sivonen, Yagut Allahverdiyeva, Eva-Mari Aro, Natalia Battchikova
(
B1 Journal article)

Integration of photosynthesis, development and stress as an opportunity for plant biology. (2015)
New Phytologist
Allahverdiyeva Y, Battchikova N, Brosché M, Fujii H, Kangasjärvi S, Mulo P, Mähönen AP, Nieminen K, Overmyer K, Salojärvi J, Wrzaczek M
(
A1 Journal article – refereed)

Proteomic approaches in research of cyanobacterial photosynthesis (2015)
Photosynthesis Research
Battchikova N, Angeleri M, Aro E-M
(
A2 Review article in a scientific journal)

Proteomic approaches in research of cyanobacterial photosynthesis (2015)
Photosynthesis Research
Natalia Battchikova, Martina Angeleri, Eva-Mari Aro
(
A1 Journal article – refereed)

SASP, a Senescence-Associated Subtilisin Protease, is involved in reproductive development and determination of silique number in Arabidopsis (2015)
Journal of Experimental Botany
Dana E. Martinez, Maria L. Borniego, Natalia Battchikova, Eva-Mari Aro, Esa Tyystjärvi, Juan J. Guiamét1
(
A1 Journal article – refereed)

Transcriptomic and Proteomic Profiling of Anabaena sp Strain 90 under Inorganic Phosphorus Stress (2015)
Applied and Environmental Microbiology
Teikari J, Osterholm J, Kopf M, Battchikova N, Wahlsten M, Aro EM, Hess WR, Sivonen K
(
A1 Journal article – refereed)


Last updated on 2019-21-07 at 02:21