Kaisa Ivaska-Papaioannou
PhD, Adjunct professor (docent)

Adjunct Professor
University Lecturer, Institute of Biomedicine (Institute of Biomedicine)

kaisa.ivaska@utu.fi
+358 29 450 4622
+358 50 407 6533

Kiinamyllynkatu 10
Turku
Medisiina
Office: C339


Areas of expertise
bone; bone cell biology; bone metabolism; bone turnover markers; osteoporosis; diabetes; biomedicine; cell biology

Research

Bone and energy metabolism

Skeleton is no longer considered an isolated organ but bone appears to exert also endcorine functions. We are interested in the crosstalk between bone metabolism and energy metabolism. Our goal is to understand how changes in energy metabolism affect bone cells, bone turnover and bone microenvironment.

Our current research interests include the role of bone-derived hormones (osteokines) in whole body energy metabolism, and the interactions between bone cells and bone marrow adipocytes. We are also interested in diabetic bone disease, and the effects of type 2 diabetes on bone metabolism and bone metabolic markers. In particular, we are interested in osteocalcin, which could provide a possible link between bone and energy metabolism in humans. We use cell culture and cell-based methods and human plasma samples obtained from clinical cohorts.

Group members: Milja Arponen (MSc)



Teaching

Cell Biology (BSc program in Biomedicine) and Methods in Cell Biology (medical students in Biomedical Research Track). Main focus in on histology and on hands-on laboratory courses in cell biology. In addition, I am mentoring BSc students and participate in the planning of curriculum.



Publications
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Dovitinib dilactic acid reduces tumor growth and tumor-induced bone changes in an experimental breast cancer bone growth model (2019)
Journal of Bone Oncology
Tiina E. Kähkönen, Johanna M. Tuomela , Tove J. Grönroos, Jussi M. Halleen, Kaisa K. Ivaska , Pirkko L. Härkönen
(
A1 Journal article – refereed)

Low free 25-hydroxyvitamin D and high vitamin D binding protein and parathyroid hormone in obese Caucasians. A complex association with bone? (2018)
PLoS ONE
Saarnio E, Pekkinen M, Itkonen ST, Kemi V, Karp H, Ivaska KK, Risteli J, Koivula MK, Kärkkäinen M, Mäkitie O, Sievänen H, Lamberg-Allardt C
(
A1 Journal article – refereed)

Role of fibroblast growth factor receptors (FGFR) and FGFR like-1 (FGFRL1) in mesenchymal stromal cell differentiation to osteoblasts and adipocytes (2018)
Molecular and Cellular Endocrinology
T. E. Kähkönen, K. K. Ivaska, M. Jian, K. G. Büki, H. K. Väänänen, P. Härkönen
(
A1 Journal article – refereed)

Testicular Function and Bone in Young Men with Severe Childhood-Onset Obesity (2018)
Hormone Research in Paediatrics
Laakso S, Viljakainen H, Lipsanen-Nyman M, Turpeinen U, Ivaska KK, Anand-Ivell R, Ivell R, Mäkitie O
(
A1 Journal article – refereed)

Changes in bone metabolism after bariatric surgery by gastric bypass or sleeve gastrectomy (2017)
BONE
Kaisa K Ivaska, Ville Huovinen, Minna Soinio, Jarna C Hannukainen, Virva Saunavaara, Paulina Salminen, Mika Helmiö, Riitta Parkkola, Pirjo Nuutila, Riku Kiviranta
(
A1 Journal article – refereed)

Bone mineral density is increased after a 16-week resistance training intervention in elderly women with decreased muscle strength (2016)
European Journal of Endocrinology
Huovinen V, Ivaska KK, Kiviranta R, Bucci M, Lipponen H, Sandboge S, Raiko J, Eriksson JG, Parkkola R, Iozzo P, Nuutila P
(
A1 Journal article – refereed)

Obese young adults exhibit lower total and lower free serum 25-hydroxycholecalciferol in a randomized vitamin D intervention (2016)
Clinical Endocrinology
Holmlund-Suila E, Pekkinen M, Ivaska KK, Andersson S, Mäkitie O, Viljakainen H
(
A1 Journal article – refereed)

Increased Body Adiposity and Serum Leptin Concentrations in Very Long-Term Adult Male Survivors of Childhood Acute Lymphoblastic Leukemia (2015)
Hormone Research in Paediatrics
Jahnukainen K, Heikkinen R, Henriksson M, Andersson S, Ivaska KK, Puukko-Viertomies LR, Makitie O
(
A1 Journal article – refereed)

The effects of acute hyperinsulinemia on bone metabolism (2015)
Endocrine Connections
Ivaska KK, Heliövaara MK, Ebeling P, Bucci M, Huovinen V, Väänänen HK, Nuutila P, Koistinen HA
(
A1 Journal article – refereed)

High Adiposity and Serum Leptin Accompanied by Altered Bone Turnover Markers in Severe Juvenile Idiopathic Arthritis. (2014)
Journal of Rheumatology
Markula-Patjas KP, Ivaska KK, Pekkinen M, Andersson S, Moilanen E, Viljakainen HT, Mäkitie O
(
A1 Journal article – refereed)

Suppressed bone turnover in obesity: a link to energy metabolism? A case-control study (2014)
Journal of Clinical Endocrinology and Metabolism
Viljakainen H, Ivaska KK, Paldánius P, Lipsanen-Nyman M, Saukkonen T, Pietiläinen KH, Andersson S, Laitinen K, Mäkitie O
(
A1 Journal article – refereed)

The effect of fibroblast growth factor receptor inhibition on the growth of breast cancer cells (2014)
European Journal of Cancer
Kahkonen TE, Toriseva M, Ivaska KK, Harkonen P
(
O2 Other)

Does The Choice Of Surgical Technique Affect Bone Turnover Changes After Bariatric Surgery? (2013)
Journal of Bone and Mineral Research
Ivaska K, Soinio M, Hannukainen J, Salminen P, Nuutila P, Kiviranta R
(
O2 Other)

Inactivation of the androgen receptor in bone-forming cells leads to trabecular bone loss in adult female mice (2013)
BoneKEy Reports
Maatta JA, Buki KG, Ivaska KK, Nieminen-Pihala V, Elo TD, Kahkonen T, Poutanen M, Harkonen P, Vaananen K
(
A1 Journal article – refereed)

Total and Carboxylated Osteocalcin Associate with Insulin Levels in Young Adults Born with Normal or Very Low Birth Weight (2013)
PLoS ONE
Paldanius PM, Ivaska KK, Hovi P, Andersson S, Eriksson JG, Vaananen K, Kajantie E, Makitie O
(
A1 Journal article – refereed)

Polymorphisms in the inflammatory genes CIITA, CLEC15A and IFNG influence BMD, bone loss and fracture in elderly women (2012)
PLoS ONE
Swanberg M, McGuigan FE, Ivaska KK, Gerdhem P, Åkesson K
(
A1 Journal article – refereed)

Tactile/kinesthetic stimulation (TKS) increases tibial speed of sound and urinary osteocalcin (U-MidOC and unOC) in premature infants (29-32 weeks PMA) (2012)
BONE
Haley S, Beachy J, Ivaska KK, Slater H, Smith S, Moyer-Mileur LJ
(
A1 Journal article – refereed)

Urinary osteocalcin and serum pro-C-type natriuretic peptide predict linear catch-up growth in infants (2012)
Journal of Bone and Mineral Research
Kilpeläinen Leena, Ivaska Kaisa K, Kuiri-Hänninen Tanja, Väänänen H Kalervo, Rehfeld Jens F, Goetze Jens P, Sankilampi Ulla, Dunkel Leo
(
A1 Journal article – refereed)

Bone turnover markers and prediction of fracture: a prospective follow-up study of 1040 elderly women for a mean of nine years (2010)
Journal of Bone and Mineral Research
Ivaska K K, Gerdhem P, Akesson K, Väänänen H K, Obrant K J
(
A1 Journal article – refereed)

Osteocalcin gene polymorphisms influence concentration of serum osteocalcin and enhance fracture identification (2010)
Journal of Bone and Mineral Research
McGuigan F, Kumar J, Ivaska K K, Obrant K J, Gerdhem P, Luthman H, Åkesson K
(
A1 Journal article – refereed)


Last updated on 2019-16-09 at 02:19