Jarmo Käpylä
Dr

University Lecturer, Biochemistry (Department of Biochemistry)

jakapy@utu.fi
+358 29 450 4704
+358 40 191 1153

Tykistökatu 6
Turku





Areas of expertise
Protein structure and function

Research

Extracellular matrix, integrins



Teaching

Lectures: Molecular biology, Proteins

Lab courses: Molecular biology techniques, Protein techniques



Publications
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Proline hydroxylation in collagen supports integrin binding by two distinct mechanisms (2018)
Journal of Biological Chemistry
Kalle H. Sipilä, Kati Drushinin, Pekka Rappu, Johanna Jokinen, Tiina A. Salminen, Antti M. Salo, Jarmo Käpylä, Johanna Myllyharju, Jyrki Heino
(
A1 Journal article – refereed)

Joint inflammation related citrullination of functional arginines in extracellular proteins (2017)
Scientific Reports
Sipila KH, Ranga V, Rappu P, Mali M, Pirila L, Heino I, Jokinen J, Kapyla J, Johnson MS, Heino J
(
A1 Journal article – refereed)

The binding capacity of alpha 1 beta 1-, alpha 2 beta 1-and alpha 10 beta 1-integrins depends on non-collagenous surface macromolecules rather than the collagens in cartilage fibrils (2017)
Matrix Biology
Woltersdorf C, Bonk M, Leitinger B, Huhtala M, Kapyla J, Heino J, Girol CG, Niland S, Eble JA, Bruckner P, Dreier R, Hansen U
(
A1 Journal article – refereed)

Extracellular citrullination inhibits the function of matrix associated TGF-beta (2016)
Matrix Biology
Sipila KH, Ranga V, Rappu P, Torittu A, Pirila L, Kapyla J, Johnson MS, Larjava H, Heino J
(
A1 Journal article – refereed)

Sulfonamide inhibitors of α2β1 integrin reveal the essential role of collagen receptors in in vivo models of inflammation. (2015)
Pharmacology Research and Perspectives
Nissinen L, Ojala M, Langen B, Dost R, Pihlavisto M, Käpylä J, Marjamäki A, Heino J.
(
A1 Journal article – refereed)

Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner. (2014)
FASEB Journal
Kalle Sipilä, Sabrina Haag, Konstantin Denessiouk, Jarmo Käpylä, Eric C. Peters, Alexander Denesyuk, Uwe Hansen, Yrjö Konttinen, Mark S. Johnson, Rikard Holmdahl, Jyrki Heino
(
A1 Journal article – refereed)

Early Chordate Origin of the Vertebrate Integrin αI Domains (2014)
PLoS ONE
Bhanupratap Singh Chouhan,Jarmo Käpylä,Konstantin Denessiouk, Alexander Denesyuk,Jyrki Heino,Mark S. Johnson
(
A1 Journal article – refereed)

In vitro blood and fibroblast responses to BisGMA-TEGDMA/bioactive glass composite implants. (2014)
Journal of Materials Science: Materials in Medicine
Abdulmajeed AA, Kokkari AK, Kapyla J, Massera J, Hupa L, Vallittu PK, Närhi TO
(
A1 Journal article – refereed)

Evolution of Cell Adhesion to Extracellular Matrix (2013) Evolution of Extracellular Matrix Johnson MS, Kapyla J, Denessiouk K, Airenne T, Chouhan BS, Heino J
(
A3 Book chapter)

Leukocyte integrins alpha(L)beta(2), alpha(M)beta(2) and alpha(X)beta(2) as collagen receptors - Receptor activation and recognition of GFOGER motif (2013)
International Journal of Biochemistry and Cell Biology
Lahti M, Heino J, Kapyla J
(
A1 Journal article – refereed)

Molecular mechanism of T-cell protein tyrosine phosphatase (TCPTP) activation by mitoxantrone (2013)
BBA - Biochimica et Biophysica Acta
Mikko Ylilauri, Elina Mattila, Elisa M Nurminen, Jarmo Käpylä, Sanna P Niinivehmas, Juha A Määttä, Ulla Pentikäinen, Johanna Ivaska, and Olli T Pentikäinen
(
A1 Journal article – refereed)

Novel alpha 2 beta 1 Integrin Inhibitors Reveal That Integrin Binding to Collagen under Shear Stress Conditions Does Not Require Receptor Preactivation (2012)
Journal of Biological Chemistry
Nissinen L, Koivunen J, Kapyla J, Salmela M, Nieminen J, Jokinen J, Sipila K, Pihlavisto M, Pentikainen OT, Marjamaki A, Heino J
(
A1 Journal article – refereed)

Collagen XXIII, Novel Ligand for Integrin alpha(2)beta(1) in the Epidermis (2011)
Journal of Biological Chemistry
Veit G, Zwolanek D, Eckes B, Niland S, Kapyla J, Zweers MC, Ishada-Yamamoto A, Krieg T, Heino J, Eble JA, Koch M
(
A1 Journal article – refereed)

Fluorescent Small Molecule Probe to Modulate and Explore alpha 2 beta 1 Integrin Function (2011)
Journal of the American Chemical Society
Koivunen JT, Nissinen L, Kapyla J, Jokinen J, Pihlavisto M, Marjamaki A, Heino J, Huuskonen J, Pentikainen OT
(
A1 Journal article – refereed)

Structure of Collagen Receptor Integrin alpha I-1 Domain Carrying the Activating Mutation E317A (2011)
Journal of Biological Chemistry
Lahti M, Bligt E, Niskanen H, Parkash V, Brandt AM, Jokinen J, Patrikainen P, Kapyla J, Heino J, Salminen TA
(
A1 Journal article – refereed)

The structure of collagen receptor integrin alpha1I domain in active conformation (2011)
Journal of Biological Chemistry
Matti Lahti, Eva Bligt, Henri Niskanen, Anna Brandt, V Parkash, Johanna Jokinen, Pekka Patrikainen, Jarmo Käpylä, Jyrki Heino, Tiina Salminen
(
A1 Journal article – refereed)

A small-molecule inhibitor of integrin alpha 2 beta 1 introduces a new strategy for antithrombotic therapy (2010)
Thrombosis and Haemostasis
Nissinen L, Pentikainen OT, Jouppila A, Kapyla J, Ojala M, Nieminen J, Lipsanen A, Lappalainen H, Eckes B, Johnson MS, Lassila R, Marjamaki A, Heino J
(
A1 Journal article – refereed)

Lumican inhibits cell migration through alpha 2 beta 1 integrin (2010)
Experimental Cell Research
Zeltz C, Brezillon S, Kapyla J, Eble JA, Bobichon H, Terryn C, Perreau C, Franz CM, Heino J, Maquart FX, Wegrowski Y
(
A1 Journal article – refereed)

Molecular mechanism of alpha 2 beta 1 integrin interaction with human echovirus 1 (2010)
EMBO Journal
Jokinen J, White DJ, Salmela M, Huhtala M, Käpylä J, Sipila K, Puranen JS, Nissinen L, Kankaanpaa P, Marjomaki V, Hyypia T, Johnson MS, Heino J
(
A1 Journal article – refereed)

Effects of conformational activation of integrin alpha 1I and alpha 2I domains on selective recognition of laminin and collagen subtypes. – Integrin alpha I domain activation (2008)
Experimental Cell Research
Tulla M, Lahti M, Puranen JS, Brandt A, Kapyla J, Domogatskaya A, Salminen TA, Tryggvason K, Johnson MS, Heino J
(
A1 Journal article – refereed)


Last updated on 2019-15-09 at 02:22

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