Johanna Tuomela
Adjunct Professor, PhD, University Lecturer

University Lecturer, Institute of Biomedicine (Institute of Biomedicine)
Adjunct Professor, Institute of Biomedicine (Institute of Biomedicine)

jomitu@utu.fi
+358 50 435 2677

Kiinamyllynkatu 10
Turku





Areas of expertise
cancer; preclinical models; innate immunity

Biography

Group Leader from 2013, Institute of Biomedicine (UTU), main funding: Academy of Finland, Jane and Aatos Erkko Foundation.

Project Researcher, Turku PET Centre 2011-2012.

Post-doctoral fellow, University of Alabama at Birmingham, AL, USA 2010-2011.

Clinical Lecturer and doctoral candidate (Department of Anatomy,UTU) 2003-2010.

Research Assistant (Department of Anatomy, UTU) 2001-2003.



Research

My research group studies the role of Toll-like receptor 9 in cancer focusing on prognostic  biomarkers and DNA damage repair mechanisms. Currently our group consists of one post doctoral fellow, six doctoral candidates and one undergraduate student.



Teaching

histology; cell biology; cancer biology



Publications
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Characterization a model of prostatic diseases and obstructive voiding induced by sex hormone imbalance in the Wistar and Noble rats (2019)
Translational andrology and urology
Yvonne Konkol, Heikki Vuorikoski, Tomi Streng, Johanna Tuomela, Jenni Bernoulli
(
A1 Journal article – refereed)

Dovitinib dilactic acid reduces tumor growth and tumor-induced bone changes in an experimental breast cancer bone growth model (2019)
Journal of Bone Oncology
Tiina E. Kähkönen, Johanna M. Tuomela , Tove J. Grönroos, Jussi M. Halleen, Kaisa K. Ivaska , Pirkko L. Härkönen
(
A1 Journal article – refereed)

Immunoterapia kolmoisnegatiivisen rintasyövän hoidossa: Uutisia San Antonion rintasyöpäkokouksesta (SABCS 2018) (2019)
BestPractice Onkologia ja hematologia
Jouko Sandholm, Johanna Tuomela, Katri Selander
(
D1 Article in a trade journal)

Synthesis of an Alkyne-Modified Bleomycin Disaccharide Precursor, Conversion to a F-18-Labeled Radiotracer, and Preliminary in vivo-PET Imaging Studies (2019)
European Journal of Organic Chemistry
Sajal K. Maity, Cheng-Bin Yim, Satish Jadhav, Alejandra Verhassel, Johanna Tuomela, Olof Solin, Tove J. Grönroos, Pasi Virta
(
A1 Journal article – refereed)

Alendronate-induced disruption of actin cytoskeleton and inhibition of migration/invasion are associated with cofilin downregulation in PC-3 prostate cancer cells (2018)
Oncotarget
Virtanen S., Ishizu T., Sandholm J., Löyttyniemi E., Väänänen HK., Tuomela J., Härkönen P.
(
A1 Journal article – refereed)

Bisfosfonaattien kohdennettu käyttö rintasyövän liitännäishoitona (2018)
BestPractice Onkologia ja hematologia
Johanna Tuomela, Katri Selander, Jouko Sandholm
(
D1 Article in a trade journal)

Chronic nonbacterial prostate inflammation in a rat model is associated with changes of gut microbiota that can be modified with a galactoglucomannan-rich hemicellulose extract in the diet (2018)
BJU International
Yvonne Konkol, Anniina Keskitalo, Heikki Vuorikoski, Sami Pietilä, Laura L. Elo, Eveliina Munukka, Jenni Bernoulli, Johanna Tuomela
(
A1 Journal article – refereed)

Evaluation of [68Ga]Ga-DOTA-TCTP-1 for the Detection of Metalloproteinase 2/9 Expression in Mouse Atherosclerotic Plaques (2018)
Molecules
Kiugel M, Hellberg S, Käkelä M, Liljenbäck H, Saanijoki T, Li XG, Tuomela J, Knuuti J, Saraste A, Roivainen A
(
A1 Journal article – refereed)

Evaluation of 68Ga-labeled peptide tracer for detection of gelatinase expression after myocardial infarction in rat (2018)
Journal of Nuclear Cardiology
Kiugel M, Kytö V, Saanijoki T, Liljenbäck H, Metsälä O, Ståhle M, Tuomela J, Li XG, Saukko P, Knuuti J, Roivainen A, Saraste A
(
A1 Journal article – refereed)

Galactoglucomannan-rich hemicellulose extract from Norway spruce (Picea abies) exerts beneficial effects on chronic prostatic inflammation and lower urinary tract symptoms in vivo (2017)
International Journal of Biological Macromolecules
Konkol Y, Vuorikoski H, Tuomela J, Holmbom B, Bernoulli J
(
A1 Journal article – refereed)

Increased FGFRL1 expression is associated with prostate cancer progression (2017)
Cancer Research
Yu L., Toriseva M., Erickson A., Seikkula H., Nurmi M., Taimen P., Boström P., Mirtti T., Alanen K., Kallajoki M., Tuomela J., Nees M., Härkönen P.
(
O2 Other)

Lipid Bilayer-Gated Mesoporous Silica Nanocarriers for Tumor-Targeted Delivery of Zoledronic Acid in Vivo. (2017)
Molecular Pharmaceutics
Diti Desai, Jixi Zhang, Jouko Sandholm, Jaakko Lehtimäki, Tove Grönroos, Johanna Tuomela, and Jessica M. Rosenholm
(
A1 Journal article – refereed)

Lower frequency of TLR9 variant associated with protection from breast cancer among African Americans (2017)
PLoS ONE
Chandler MR, Keene KS, Tuomela JM, Forero-Torres A, Desmond R, Vuopala KS, Harris KW, Merner ND, Selander KS
(
A1 Journal article – refereed)

Oncolytic alphavirus SFV-VA7 efficiently eradicates subcutaneous and orthotopic human prostate tumours in mice (2017)
British Journal of Cancer
Martikainen M, Ruotsalainen J, Tuomela J, Härkönen P, Essand M, Heikkilä J, Hinkkanen A
(
A1 Journal article – refereed)

Selective drug sensitivity score (DSS) for indolent and aggressive prostate cancer cell lines (2017)
Cancer Research
Jenni Mäki-Jouppila, Jenni Bernoulli, Johanna Tuomela, Mari I. Suominen, Jussi M. Halleen, Sanna Timonen, Elina Huovari, Katja Suomi, Swapnil Potdar, Päivi Östling, Jani Saarela, Katja M. Fagerlund
(
O2 Other)

Differential drug sensitivity score (DSS) for indolent and aggressive prostate cancer cell lines (2016)
European Journal of Cancer
Suominen MI, Maki-Jouppila J, Bernoulli J, Tuomela J, Halleen JM, Timonen S, Huovari E, Suomi K, Potdar S, Ostling R, Saarela J, Fagerlund KM
(
O2 Other)

Increased expression of fibroblast growth factor 13 in prostate cancer is associated with shortened time to biochemical recurrence after radical prostatectomy (2016)
International Journal of Cancer
Yu L, Toriseva M, Tuomala M, Seikkula H, Elo T, Tuomela J, Kallajoki M, Mirtti T, Taimen P, Bostrom PJ, Alanen K, Nurmi M, Nees M, Harkonen P
(
A1 Journal article – refereed)

Spheroid culture of LuCaP 136 patient-derived xenograft enables versatile preclinical models of prostate cancer (2016)
Clinical and Experimental Metastasis
Valta MP, Zhao HJ, Saar M, Tuomela J, Nolley R, Linxweiler J, Sandholm J, Lehtimaki J, Harkonen P, Coleman I, Nelson PS, Corey E, Peehl DM
(
A1 Journal article – refereed)

Telomeric G-quadruplex-forming DNA fragments induce TLR9-mediated and LL-37-regulated invasion in breast cancer cells in vitro (2016)
Breast Cancer Research and Treatment
Tuomela JM, Sandholm JA, Kaakinen M, Hayden KL, Haapasaari KM, Jukkola-Vuorinen A, Kauppila JH, Lehenkari PP, Harris KW, Graves DE, Selander KS
(
A1 Journal article – refereed)

Toll-like receptor 9 expression is associated with breast cancer sensitivity to the growth inhibitory effects of bisphosphonates in vitro and in vivo (2016)
Oncotarget
Sandholm J, Lehtimäki J, Ishizu T, Velu SE, Clark J, Härkönen P, Jukkola-Vuorinen A, Schrey A, Harris KW, Tuomela JM, Selander KS
(
A1 Journal article – refereed)


Last updated on 2019-21-08 at 02:21