Jyrki Heino


Scientific Director, BioCity Turku (Turku Centre for Biotechnology)
Professor, Biochemistry (Department of Biochemistry)

jyheino@utu.fi
+358 29 450 2197
+358 50 523 8351

Tykistökatu 6
Turku





Publications
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Enteric Species F Human Adenoviruses use Laminin-Binding Integrins as Co-Receptors for Infection of Ht-29 Cells (2018)
Scientific Reports
Anandi Rajan, B. David Persson, Lars Frängsmyr, Annelie Olofsson, Linda Sandblad, Jyrki Heino, Yoshikazu Takada, A. Paul Mould, Lynn M. Schnapp, Jason Gall, Niklas Arnberg
(
A1 Journal article – refereed)

Integrin α2β1 decelerates proliferation, but promotes survival and invasion of prostate cancer cells (2018)
Oncotarget
Ojalill M., Parikainen M., Rappu P., Aalto E., Jokinen J., Virtanen N., Siljamäki E., Heino J.
(
A1 Journal article – refereed)

Long non-coding RNA PICSAR decreases adhesion and promotes migration of squamous carcinoma cells by downregulating α2β1 and α5β1 integrin expression (2018)
Biology Open
Minna Piipponen, Jyrki Heino, Veli-Matti Kähäri, Liisa Nissinen
(
A1 Journal article – refereed)

Proline hydroxylation in collagen supports integrin binding by two distinct mechanisms (2018)
Journal of Biological Chemistry
Journal of Investigative Dermatology
Kalle H. Sipilä, Kati Drushinin, Pekka Rappu, Johanna Jokinen, Tiina A. Salminen, Antti M. Salo, Jarmo Käpylä, Johanna Myllyharju, Jyrki Heino
(
A1 Journal article – refereed)

The composition of prostate core matrisome in vivo and in vitro unveiled by mass spectrometric analysis (2018)
Prostate
Marjaana Ojalill, Pekka Rappu, Elina Siljamäki, Pekka Taimen, Peter Boström, Jyrki Heino
(
A1 Journal article – refereed)

Integrin α2β1 in nonactivated conformation can induce focal adhesion kinase signaling (2017)
Scientific Reports
Salmela Maria, Jokinen Johanna, Tiitta Silja, Rappu Pekka, Cheng Holland R, Heino Jyrki
(
A1 Journal article – refereed)

Joint inflammation related citrullination of functional arginines in extracellular proteins (2017)
Scientific Reports
Sipila KH, Ranga V, Rappu P, Mali M, Pirila L, Heino I, Jokinen J, Kapyla J, Johnson MS, Heino J
(
A1 Journal article – refereed)

The binding capacity of alpha 1 beta 1-, alpha 2 beta 1-and alpha 10 beta 1-integrins depends on non-collagenous surface macromolecules rather than the collagens in cartilage fibrils (2017)
Matrix Biology
Woltersdorf C, Bonk M, Leitinger B, Huhtala M, Kapyla J, Heino J, Girol CG, Niland S, Eble JA, Bruckner P, Dreier R, Hansen U
(
A1 Journal article – refereed)

Epithelial Microvesicles Promote an Inflammatory Phenotype in Fibroblasts (2016)
Journal of Dental Research
Bi J, Koivisto L, Owen G, Huang P, Wang Z, Shen Y, Bi L, Rokka A, Haapasalo M, Heino J, Hakkinen L, Larjava HS
(
A1 Journal article – refereed)

Extracellular citrullination inhibits the function of matrix associated TGF-beta (2016)
Matrix Biology
Sipila KH, Ranga V, Rappu P, Torittu A, Pirila L, Kapyla J, Johnson MS, Larjava H, Heino J
(
A1 Journal article – refereed)

Platelet response to a small molecule inhibitor of α2β1 integrin is associated with ITGA2 C807T dimorphism. (2016)
Platelets
Nissinen L, Rappu P, Ollikka P, Nieminen J, Marjamäki A, Heino J
(
A1 Journal article – refereed)

Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators (2016)
Cell Stem Cell
Silberstein L, Goncalves KA, Kharchenko PV, Turcotte R, Kfoury Y, Mercier F, Baryawno N, Severe N, Bachand J, Spencer JA, Papazian A, Lee D, Chitteti BR, Srour EF, Hoggatt J, Tate T, Lo Celso C, Ono N, Nutt S, Heino J, Sipila K, Shioda T, Osawa M, Lin CP, Hu GF, Scadden DT
(
A1 Journal article – refereed)

The PIM1 kinase promotes prostate cancer cell migration and adhesion via multiple signalling pathways (2016)
Experimental Cell Research
Niina M. Santio, Maria Salmela, Heidi Arola, Sini K.Eerola, Jyrki Heino, Eeva-Marja Rainio, Päivi J.Koskinen
(
A1 Journal article – refereed)

Tumor promoter PMA enhances kindlin-2 and decreases vimentin recruitment into cell adhesion sites (2016)
International Journal of Biochemistry and Cell Biology
Salmela M, Rappu P, Lilja J, Niskanen H, Taipalus E, Jokinen J, Heino J
(
A1 Journal article – refereed)

Cell and Molecular Biology of Wound Healing. (2015) Stem Cell Biology and Tissue Engineering in Dental Sciences. L. Häkkinen, L. Koivisto, J. Heino, and H. Larjava
(
A3 Book chapter)

Cellular recognition and macropinocytosis-like internalization of nanoparticles targeted to integrin α2β1 (2015)
Nanoscale
P. Kankaanpää, S. Tiitta, L. Bergman, A.-B. Puranen, E. von Haartman, M. Lindén, J. Heino
(
A1 Journal article – refereed)

Histidine-rich glycoprotein blocks collagen-binding integrins and adhesion of endothelial cells through low-affinity interaction with α2 integrin. (2015)
Matrix Biology
Roche F, Sipilä K, Honjo S, Johansson S, Tugues S, Heino J, Claesson-Welsh L
(
A1 Journal article – refereed)

Keratinocyte Microvesicles Regulate the Expression of Multiple Genes in Dermal Fibroblasts (2015)
Ping Huang, Jiarui Bi, Gethin R. Owen, Weimin Chen, Anne Rokka, Leeni Koivisto, Jyrki Heino, Lari Häkkinen, Hannu Larjava
(
A1 Journal article – refereed)

Sulfonamide inhibitors of α2β1 integrin reveal the essential role of collagen receptors in in vivo models of inflammation. (2015)
Pharmacology Research and Perspectives
Nissinen L, Ojala M, Langen B, Dost R, Pihlavisto M, Käpylä J, Marjamäki A, Heino J.
(
A1 Journal article – refereed)

Cellular signaling by collagen-binding integrins (2014) Heino J.
(
C1 Scientific book)


Last updated on 2019-24-06 at 02:22