Klaus Elenius
MD, PhD, professor

Professor, Institute of Biomedicine (Institute of Biomedicine)

klaele@utu.fi
+358 29 450 4393
+358 50 050 5142

Tykistökatu 6 A
Turku




Research


ACTIONABLE RECEPTOR TYROSINE KINASE SIGNALING

Our goal is to understand how receptor tyrosine kinases (RTK) regulate the pathogenesis of human diseases, such as cancer. This information is needed for the development of molecularly targeted therapies. To recognize aberrations of RTK signaling in diseased tissue our laboratory also works on the molecular mechanism by which RTKs control normal processes, such as embryonic development. The work mainly focuses on the ErbB family of RTKs. Our laboratory has contributed to the field by e.g. by characterizing novel RTK signaling mechanisms, by identifying novel ErbB4 isoforms, and by determining the role of ErbBs and their ligands in angiogenesis.

Current topics

  • Screens for predictive RTK mutations
  • Novel RTK signaling mechanisms
  • Development of preclinical models for development novel RTK inhibitors
  • Sequencing of RTK inhibitor drug administration with cytotoxic agents
  • In vitro “basket trials” with ErbB inhibitor drugs
  • RTK signaling in angiogenesis and cardiovascular diseases
  • RTKs in pediatric malignancies
  • Biological role of novel ErbB4 isoforms in diseases and development

Elenius Lab members

  • Anne Jokilammi, PhD
  • Elli Narvi, PhD
  • Deepankar Chakroborty, MSc
  • Juho Heliste, MD
  • Marika Koivu, MSc 
  • Johannes Merilahti, MSc
  • Veera Ojala, MSc
  • Janne Nordberg, MD
  • Fred Saarinen, MSc
  • Katri Vaparanta, MSc
  • Kaisa Aalto, BM
  • Maria Helkkula, BM
  • Matias Mäenpää, BM
  • Peppi Kirjalainen, BM
  • Jori Torkkila, BM



Publications
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An unbiased in vitro screen for activating epidermal growth factor receptor mutations (2019)
Journal of Biological Chemistry
Chakroborty D, Kurppa KJ, Paatero I, Ojala VK, Koivu M, Tamirat MZ, Koivunen JP, Jänne PA, Johnson MS, Elo LL, Elenius K
(
A1 Journal article – refereed)

ErbB4 tyrosine kinase inhibition impairs neuromuscular development in zebrafish embryos (2019) Paatero I, Veikkolainen V, Mäenpää M, Schmelzer E, Belting HG, Pelliniemi LJ, Elenius K
(
A1 Journal article – refereed)

Gamma-secretase-dependent signaling of receptor tyrosine kinases (2019) Merilahti JAM, Elenius K
(
A2 Review article in a scientific journal)

Different responses of colorectal cancer cells to alternative sequences of cetuximab and oxaliplatin (2018)
Scientific Reports
Narvi E, Vaparanta K, Karrila A, Chakroborty D, Knuutila S, Pulliainen A, Sundvall M, Elenius K
(
A1 Journal article – refereed)

Geenidiagnostiikkaan perustuva syövän hoito - tätä päivää, tulevaisuutta vai toiveajattelua? (2018)
Duodecim
Alanne E, Joensuu H, Elenius K
(
A2 Review article in a scientific journal)

Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target (2018)
BMC Cardiovascular Disorders
Juho Heliste, Anne Jokilammi, Ilkka Paatero, Deepankar Chakroborty, Christoffer Stark, Timo Savunen, Maria Laaksonen, Klaus Elenius
(
A1 Journal article – refereed)

The Mutational Profile of Unicystic Ameloblastoma (2018)
Journal of Dental Research
Heikinheimo K, Huhtala JM, Thiel A, Kurppa KJ, Heikinheimo H, Kovac M, Kragelund C, Warfvinge G, Dawson H, Elenius K, Ristimäki A, Baumhoer D, Morgan PR
(
A1 Journal article – refereed)

Genome-wide screen of gamma-secretase-mediated intramembrane cleavage of receptor tyrosine kinases (2017)
Molecular Biology of the Cell
Merilahti JAM, Ojala VK, Knittle AM, Pulliainen AT, Elenius K
(
A1 Journal article – refereed)

Human Metaplastic Breast Carcinoma and Decorin (2017) Boström P, Sainio A, Eigėlienė N, Jokilammi A, Elenius K, Koskivuo I, Järveläinen H
(
A1 Journal article – refereed)

SUMOylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the ErbB4 receptor tyrosine kinase (2017)
Journal of Biological Chemistry
Knittle AM, Helkkula M, Johnson MS, Sundvall M, Elenius K
(
A1 Journal article – refereed)

Activating ERBB4 mutations in non-small cell lung cancer (2016)
Oncogene
Kurppa K., Denessiouk K., Johnson M., Elenius K.
(
A1 Journal article – refereed)

Farmakogenetiikka saapuu klinikkaan (2016)
Duodecim
Juho Heliste, Klaus Elenius, Mikko Niemi, Varpu Elenius
(
A2 Review article in a scientific journal)

Novel Targets for the Treatment of Ameloblastoma (2015)
Journal of Dental Research
K. Heikinheimo, K.J. Kurppa, K. Elenius
(
A2 Review article in a scientific journal)

ErbB4, a receptor tyrosine kinase, coordinates organization of the seminiferous tubules in the developing testis. (2014)
Molecular Endocrinology -Baltimore-
Florence Naillat, Ville Veikkolainen, Ilkka Miinalainen, Petra Sipilä, Matti Poutanen, Klaus Elenius, Seppo J. Vainio
(
A1 Journal article – refereed)

ERBB4 Promoter Polymorphism Is Associated with Poor Distant Disease-Free Survival in High-Risk Early Breast Cancer (2014)
PLoS ONE
Kari J. Kurppa, Matjaz Rokavec, Maria Sundvall, Pirkko-Liisa Kellokumpu-Lehtinen, Heikki Joensuu, Hiltrud Brauch, Klaus Elenius
(
A1 Journal article – refereed)

High frequency of BRAF V600E mutations in ameloblastoma (2014)
Journal of Pathology
Kari J Kurppa, Javier Catón, Peter R Morgan, Ari Ristimäki, Blandine Ruhin, Jari Kellokoski, Klaus Elenius, Kristiina Heikinheimo
(
A1 Journal article – refereed)

Hypoxia-inducible Factor-1α Induces ErbB4 Signaling in the Differentiating Mammary Gland (2014)
Journal of Biological Chemistry
Ilkka Paatero, Tiffany N. Seagroves, Katri Vaparanta, Wen Han, Frank E. Jones, Randall S. Johnson, Klaus Elenius
(
A1 Journal article – refereed)

Overexpression of ERBB4 JM-a CYT-1 and CYT-2 isoforms in transgenic mice reveal isoform-specific roles in mammary gland development and carcinogenesis (2014)
Breast Cancer Research
Vikram B Wali, Maureen Gilmore-Hebert, Ramanaiah Mamillapalli, Jonathan W Haskins, Kari J Kurppa, Klaus Elenius, Carmen J Booth, David F Stern
(
A1 Journal article – refereed)

Sähköiset potilastietojärjestelmät geenitestien hyödyntämisessä (2014)
Moodi
Elenius K, Kankuri-Tammilehto M
(
D1 Article in a trade journal)

CYT-1 isoform of ErbB4 is an independent prognostic factor in serous ovarian cancer and selectively promotes ovarian cancer cell growth in vitro (2013)
Gynecologic Oncology
Paatero I, Lassus H, Junttila TT, Kaskinen M, Butzow R, Elenius K
(
A1 Journal article – refereed)


Last updated on 2019-16-07 at 02:24