Pirkko Heikinheimo
Department of Biochemistry and Turun Normaalikoulu pirkko.heikinheimo@utu.fi Tykistökatu 6 Turku Office: B205 |
Publications
- amamutdb.no: A Relational Database for MAN2B1 Allelic Variants that Compiles Genotypes, Clinical Phenotypes, and Biochemical and Structural Data of Mutant MAN2B1 in -Mannosidosis (2015)
- Human Mutation
(Refereed journal article or data article (A1)) - Is the Bovine lysosomal phospholipase B like protein an amidase? (2014)
- Proteins
(Refereed journal article or data article (A1)) - Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation (2013)
- Diabetes
(Refereed journal article or data article (A1)) - A monomeric TIM-barrel structure from Pyrococcus furiosus is optimized for extreme temperatures (2012)
- Acta Crystallographica Section D: Biological Crystallography
(Refereed journal article or data article (A1)) - Systematic Structure-Activity Study on Potential Chaperone Lead Compounds for Acid alpha-Glucosidase (2012)
- ChemMedChem
(Refereed journal article or data article (A1)) - Molecular and cellular characterization of novel alpha-mannosidosis mutations (2011)
- Human Molecular Genetics
(Refereed journal article or data article (A1)) - Overexpression of Man2C1 leads to protein underglycosylation and upregulation of endoplasmic reticulum-associated degradation pathway (2011)
- Glycobiology
(Refereed journal article or data article (A1)) - Coordination sphere of the third metal site is essential to the activity and metal selectivity of alkaline phosphatases (2010)
- Protein Science
(Refereed journal article or data article (A1)) - A complete structural description of the catalytic cycle of yeast pyrophosphatase (2007) Oksanen E, Ahonen AK, Tuominen H, Tuominen V, Lahti R, Goldman A, Heikinheimo P
(Refereed journal article or data article (A1)) - Characterisation and subcellular localisation of human neutral class II alfa-mannosidase (2007)
- Glycobiology
(Refereed journal article or data article (A1)) - Production and preliminary analysis of perdeuterated yeast inorganic pyrophosphatase crystals suitable for neutron diffraction (2004)
- Acta Crystallographica Section D: Biological Crystallography
(Refereed journal article or data article (A1)) - Functional and structural characterization of disease-causing mutations in alpha-mannosidosis. (2002)
- American Journal of Human Genetics
(Refereed article in conference proceedings (A4)) - Toward a quantum-mechanical description of metal-assisted phosphoryl transfer in pyrophosphatase (2001) Heikinheimo P, Tuominen V, Ahonen AK, Teplyakov A, Cooperman BS, Baykov AA, Lahti R, Goldman A
(Refereed journal article or data article (A1)) - The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: Structural studies and mechanistic implications (1998) Tuominen V, Heikinheimo P, Kajander T, Torkkel T, Hyytia T, Kapyla J, Lahti R, Cooperman BS, Goldman A
(Refereed journal article or data article (A1)) - Structural and functional consequences of substitutions at the tyrosine 55 lysine 104 hydrogen bond in Escherichia coli inorganic pyrophosphatase (1997) Fabrichniy IP, Kasho VN, Hyytia T, Salminen T, Halonen P, Dudarenkov VY, Heikinheimo P, Chernyak VY, Goldman A, Lahti R, Cooperman BS, Baykov AA
(Refereed journal article or data article (A1)) - The three metal ion mechanism of inorganic pyrophosphatases (1997)
- Protein Engineering
(Refereed journal article or data article (A1)) - A site-directed mutagenesis study of Saccharomyces cerevisiae pyrophosphatase - Functional conservation of the active site of soluble inorganic pyrophosphatases (1996)
- European Journal of Biochemistry
(Refereed journal article or data article (A1)) - The structural basis for pyrophosphatase catalysis (1996)
- Structure
(Refereed journal article or data article (A1)) - New crystal forms of Escherichia coli and Saccharomyces cerevisiae soluble inorganic pyrophosphatases (1995)
- Acta Crystallographica Section D: Biological Crystallography
(Refereed journal article or data article (A1)) - Structure and function analysis of Escherichia coli inorganic pyrophosphatase: is a hydroxide ion the key to catalysis? (1995)
- Biochemistry
(Refereed journal article or data article (A1))