Pirkko Heikinheimo


Adjunct Professor, Faculty of Science and Engineering (Faculty of Science and Engineering)
University Lecturer, Biochemistry (Department of Biochemistry)
Department of Biochemistry and Turun Normaalikoulu
pirkko.heikinheimo@utu.fi
Tykistökatu 6
Turku
Arcanum
Office: B205





Publications
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amamutdb.no: A Relational Database for MAN2B1 Allelic Variants that Compiles Genotypes, Clinical Phenotypes, and Biochemical and Structural Data of Mutant MAN2B1 in -Mannosidosis (2015)
Human Mutation
Stensland HMFR, Frantzen G, Kuokkanen E, Buvang EK, Klenow HB, Heikinheimo P, Malm D, Nilssen O
(
A1 Journal article – refereed)

Is the Bovine lysosomal phospholipase B like protein an amidase? (2014)
Proteins
Heidi Repo, Elina Kuokkanen, Esko Oksanen, Adrian Goldman, Pirkko Heikinheimo
(
A1 Journal article – refereed)

Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation (2013)
Diabetes
Bonnycastle LL, Chines PS, Hara T, Huyghe JR, Swift AJ, Heikinheimo P, Mahadevan J, Peltonen S, Huopio H, Nuutila P, Narisu N, Goldfeder RL, Stitzel ML, Lu SM, Boehnke M, Urano F, Collins FS, Laakso M
(
A1 Journal article – refereed)

A monomeric TIM-barrel structure from Pyrococcus furiosus is optimized for extreme temperatures (2012)
Acta Crystallographica Section D: Biological Crystallography
Repo H, Oeemig JS, Djupsjobacka J, Iwai H, Heikinheimo P
(
A1 Journal article – refereed)

Systematic Structure-Activity Study on Potential Chaperone Lead Compounds for Acid alpha-Glucosidase (2012)
ChemMedChem
Bruckmann C, Repo H, Kuokkanen E, Xhaard H, Heikinheimo P
(
A1 Journal article – refereed)

Molecular and cellular characterization of novel alpha-mannosidosis mutations (2011)
Human Molecular Genetics
Kuokkanen E, Stensland HMFR, Smith W, Buvang EK, Nguyen L, Nilssen Ø, Heikinheimo P
(
A1 Journal article – refereed)

Overexpression of Man2C1 leads to protein underglycosylation and upregulation of endoplasmic reticulum-associated degradation pathway (2011)
Glycobiology
Bernon C, Carre Y, Kuokkanen E, Slomianny MC, Mir AM, Krzewinski F, Cacan R, Heikinheimo P, Morelle W, Michalski JC, Foulquier F, Duvet S
(
A1 Journal article – refereed)

A complete structural description of the catalytic cycle of yeast pyrophosphatase (2007) Oksanen E, Ahonen AK, Tuominen H, Tuominen V, Lahti R, Goldman A, Heikinheimo P
(
A1 Journal article – refereed)

Characterisation and subcellular localisation of human neutral class II alfa-mannosidase (2007)
Glycobiology
Elina Kuokkanen, Wesley Smith, Marika Mäkinen, Heidi Tuominen, Maija Puhka, Eija Jokitalo, Ole-Kristian Tollersrud, Rene Cacan, Sandrine Duvet, Thomas Berg, Pirkko Heikinheimo
(
A1 Journal article – refereed)

Production and preliminary analysis of perdeuterated yeast inorganic pyrophosphatase crystals suitable for neutron diffraction (2004)
Acta Crystallographica Section D: Biological Crystallography
Tuominen VU, Myles DAA, Dauvergne MT, Lahti R, Heikinheimo P, Goldman A
(
A1 Journal article – refereed)

Functional and structural characterization of disease-causing mutations in alpha-mannosidosis. (2002)
American Journal of Human Genetics
Conference proceedings Stensland HMFR, Hansen GM, Heikinheimo P, Tollersrud OK, Nilssen Ø
(
A4 Article in conference proceedings)

Toward a quantum-mechanical description of metal-assisted phosphoryl transfer in pyrophosphatase (2001) Heikinheimo P, Tuominen V, Ahonen AK, Teplyakov A, Cooperman BS, Baykov AA, Lahti R, Goldman A
(
A1 Journal article – refereed)

The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: Structural studies and mechanistic implications (1998) Tuominen V, Heikinheimo P, Kajander T, Torkkel T, Hyytia T, Kapyla J, Lahti R, Cooperman BS, Goldman A
(
A1 Journal article – refereed)

Structural and functional consequences of substitutions at the tyrosine 55 lysine 104 hydrogen bond in Escherichia coli inorganic pyrophosphatase (1997) Fabrichniy IP, Kasho VN, Hyytia T, Salminen T, Halonen P, Dudarenkov VY, Heikinheimo P, Chernyak VY, Goldman A, Lahti R, Cooperman BS, Baykov AA
(
A1 Journal article – refereed)

The three metal ion mechanism of inorganic pyrophosphatases (1997)
Protein Engineering
Heikinheimo P, Tuominen V, Lahti R, Cooperman BS, Goldman A
(
A1 Journal article – refereed)

A site-directed mutagenesis study of Saccharomyces cerevisiae pyrophosphatase - Functional conservation of the active site of soluble inorganic pyrophosphatases (1996)
European Journal of Biochemistry
Heikinheimo P, Pohjanjoki P, Helminen A, Tasanen M, Cooperman BS, Goldman A, Baykov A, Lahti R
(
A1 Journal article – refereed)

The structural basis for pyrophosphatase catalysis (1996)
Structure
Heikinheimo P, Lehtonen J, Baykov A, Lahti R, Cooperman BS, Goldman A
(
A1 Journal article – refereed)

New crystal forms of Escherichia coli and Saccharomyces cerevisiae soluble inorganic pyrophosphatases (1995)
Acta Crystallographica Section D: Biological Crystallography
HEIKINHEIMO P, SALMINEN T, LAHTI R, COOPERMAN B, GOLDMAN A
(
A1 Journal article – refereed)

Structure and function analysis of Escherichia coli inorganic pyrophosphatase: is a hydroxide ion the key to catalysis? (1995)
Biochemistry
Salminen T, Käpylä J, Heikinheimo P, Kankare J, Goldman A, Heinonen J, Baykov AA, Cooperman BS, Lahti R.
(
A1 Journal article – refereed)

Characterization of the 5′ flanking region of the Escherichia coli ppa gene encoding inorganic pyrophosphatase: mutations in the ribosome-binding site decrease the level of ppa mRNA (1991)
Journal of general microbiology
Lahti R, Perälä M, Heikinheimo P, Pitkäranta T, Kukko-Kalske E, Heinonen J
(
A1 Journal article – refereed)


Last updated on 2019-21-08 at 02:22