Riikka Lund
Head of Finnish Functional Genomics Centre, group leader

Senior Researcher, Finnish Functional Genomics Centre (Turku Centre for Biotechnology)
Adjunct Professor, Institute of Biomedicine (Institute of Biomedicine)

riikka.lund@utu.fi
+358 29 450 3793
+358 50 310 0060

Tykistökatu 6
Turku


Areas of expertise
Epigenomics; genomics; transcriptomics; pluripotent stem cells; biomedicine; development; aging; molecular mechanisms of diseases; next-generation sequencing; genome-wide methods

Biography

Riikka Lund is the head of Finnish Functional Genomics Centre (2013-), a functional genomics core facility operating in Turku, Finland. In addition, she leads the Biomedical Epigenomics research group and is actively engaged in teaching. She is also a co-PI in the Biocenter Finland Genome-wide methods platform (https://www.biocenter.fi/index.php/technology-platform-services/genome-wide-methods), and since 2016, has been a co-director of the Computational and Molecular Methodologies for Life Sciences (CompLifeSci) Biocity Turku Research Programme (https://www.biocity.turku.fi/research-programmes/computational-and-molecular-methodologies-for-life-sciences-complifesci/). Since 2018 she has also been an editorial board member of Scientific Reports journal and provides expertise in many international tasks.

She completed her M.Sc. degree in 2001 with a major in genetics at the Department of Biology, Faculty of Mathematics and Natural Sciences, University of Turku, Finland. She carried out part of her studies at the Royal Melbourne institute of Technology, Australia. She gained her PhD in 2004 in Molecular Immunology and Medical Genetics at the Faculty of Medicine, University of Turku. She did her postdoc at the Centre for Stem Cell Biology, University of Sheffield in 2007-2008 with the focus on understanding genomic stability of pluripotent stem cells. In addition, to develop her expertise and update her skills in the latest technologies and research methods, she has carried out several short visits to national and international units (e.g. 2018 University of Southern Denmark; 2013 Broad Institute, USA; 2011 Diagenode, Belgium; 2009, 2006 University of Sheffied, UK; 2005 University of California, USA; 2002 Affymetrix, USA; 2001 Deutches Rheuma-Forschungszentrum, Germany). In 2013 she was awarded with the Millenium Distinct Technology Award for her contributions in stem cell research. In 2014 become Adjunct Professor in Molecular Biology in the faculty of Medicine, University of Turku.  



Research

Biomedical Epigenomics group run by Lund exploits the latest technologies and cutting-edge methods to study genome function during early human development, aging and in diseases. The aim of the research is to understand how genetic and environmental factors influence development and health status of an individual and to reveal the molecular mechanisms of disease development. Furthermore, the goal is to find novel type of disease marker candidates and targets for drug development. By providing novel innovative approaches enabling prediction, early diagnosis and efficient precision treatment of diseases the ultimate goal of this research is to promote lifelong health.



Teaching
Epigenomics; genomics; transcriptomics; next-generation sequencing; stem cells and regenerative medicine. 

Publications
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Atopic asthma after rhinovirus-induced wheezing is associated with DNA methylation change in the SMAD3 gene promoter (2018)
Allergy: European Journal of Allergy and Clinical Immunology: Supplement
R. J. Lund, M. Osmala, M. Malonzo, M. Lukkarinen, A. Leino, J. Salmi, S. Vuorikoski, R. Turunen, T. Vuorinen, C. Akdis, H. Lähdesmäki, R. Lahesmaa, T. Jartti
(
A1 Journal article – refereed)

The impact of probiotic supplementation during pregnancy on DNA methylation of obesity-related genes in mothers and their children (2018)
European Journal of Nutrition
Sanna Vähämiko, Asta Laiho, Riikka Lund, Erika Isolauri, Seppo Salminen, Kirsi Laitinen
(
A1 Journal article – refereed)

DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer (2017)
Scientific Reports
Riikka J. Lund, Kaisa Huhtinen, Jussi Salmi, Juha Rantala, Elizabeth V. Nguyen, Robert Moulder, David R. Goodlett, Riitta Lahesmaa, Olli Carpén
(
A1 Journal article – refereed)

Epigenomic Landscapes of hESC-Derived Neural Rosettes: Modeling Neural Tube Formation and Diseases (2017)
Cell Reports
Cristina Valensisi, Colin Andrus, Sam Buckberry, Naresh Doni Jayavelu, Riikka Lund, Ryan Lister, David Hawkins
(
A1 Journal article – refereed)

Methylome Analysis of Human Bone Marrow MSCs Reveals Extensive Age- and Culture-Induced Changes at Distal Regulatory Elements (2017)
Stem Cell Reports
Kalyan K. Pasumarthy, Naresh Doni Jayavelu, Lotta Kilpinen, Colin Andrus, Stephanie L. Battle, Matti Korhonen,
Petri Lehenkari, Riikka Lund, Saara Laitinen, R. David Hawkins

(
A1 Journal article – refereed)

RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA+ and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells (2017)
Stem Cell Reports
Riikka J. Lund, Nelly Rahkonen, Maia Malonzo, Leni Kauko, Maheswara Reddy Emani, Virpi Kivinen, Elisa Närvä, Esko Kemppainen, Asta Laiho, Heli Skottman, Outi Hovatta, Omid Rasool, Matti Nykter, Harri Lähdesmäki, Riitta Lahesmaa
(
A1 Journal article – refereed)

Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells (2016)
Scientific Reports
Konki M, Pasumarthy K, Malonzo M, Sainio A, Valensisi C, Soderstrom M, Emani MR, Stubb A, Narva E, Ghimire B, Laiho A, Jarvelainen H, Lahesmaa R, Lahdesmaki H, Hawkins RD, Lund RJ
(
A1 Journal article – refereed)

Mature Let-7 miRNAs fine tune expression of LIN28B in pluripotent human embryonic stem cells (2016)
Stem Cell Research
Nelly Rahkonen, Aki Stubb, Maia Malonzo, Sanna Edelman, Maheswara Reddy Emani, Elisa Närvä, Harri Lähdesmäki, Hannele Ruohola-Baker, Riitta Lahesmaa, Riikka Lund
(
A1 Journal article – refereed)

Decorin in Human Colon Cancer: Localization In Vivo and Effect on Cancer Cell Behavior In Vitro. (2015)
Journal of Histochemistry and Cytochemistry
Nyman MC, Sainio AO, Pennanen MM, Lund RJ, Vuorikoski S, Sundström JT, Järveläinen HT
(
A1 Journal article – refereed)

Identification of global regulators of T-helper cell lineage specification (2015)
Genome Medicine
Kanduri K, Tripathi S, Larjo A, Mannerstrom H, Ullah U, Lund R, Hawkins RD, Ren B, Lahdesmaki H, Lahesmaa R
(
A1 Journal article – refereed)

The L1TD1 Protein Interactome Reveals the Importance of Post-transcriptional Regulation in Human Pluripotency (2015)
Stem Cell Reports
Emani MR, Närvä E, Stubb A, Chakroborty D, Viitala M, Rokka A, Rahkonen N, Moulder R, Denessiouk K, Trokovic R, Lund R, Elo LL, Lahesmaa R.
(
A1 Journal article – refereed)

Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity (2014)
Genome Medicine
Barbara Hrdlickova, Vinod Kumar, Kartiek Kanduri, Daria V Zhernakova, Subhash Tripathi, Juha Karjalainen, Riikka J Lund, Yang Li, Ubaid Ullah, Rutger Modderman, Wayel Abdulahad, Harri Lähdesmäki, Lude Franke, Riitta Lahesmaa, Cisca Wijmenga, Sebo Withoff
(
A1 Journal article – refereed)

Gut microbiota as an epigenetic regulator: pilot study based on whole genome methylation analysis (2014)
mBio
Kumar H, Lund R, Laiho A, Lundelin K, Ley RE, Isolauri E, Salminen S
(
A1 Journal article – refereed)

Notch signaling regulates the differentiation of neural crest from human pluripotent stem cells (2014)
Journal of Cell Science
Noisa Parinya, Lund Carina, Kanduri Kartiek, Lund Riikka, Lähdesmäki Harri, Lahesmaa Riitta, Lundin Karolina, Chokechuwattanalert Hataiwan, Otonkoski Timo, Tuuri Timo, Raivio Taneli
(
A1 Journal article – refereed)

A novel feeder-free culture system for human pluripotent stem cell culture and induced pluripotent stem cell derivation (2013)
PLoS ONE
Sanna Vuoristo, Sanna Toivonen, Jere Weltner, Milla Mikkola, Jarkko Ustinov, Ras Trokovic, Jaan Palgi, Riikka Lund, Timo Tuuri, Timo Otonkoski
(
A1 Journal article – refereed)

A Novel Feeder-Free Culture System for Human Pluripotent Stem Cell Culture and Induced Pluripotent Stem Cell Derivation (2013)
PLoS ONE
Vuoristo S, Toivonen S, Weltner J, Mikkola M, Ustinov J, Trokovic R, Palgi J, Lund R, Tuuri T, Otonkoski T
(
A1 Journal article – refereed)

Continuous Hypoxic Culturing of Human Embryonic Stem Cells Enhances SSEA-3 and MYC Levels (2013)
PLoS ONE
Narva E, Pursiheimo JP, Laiho A, Rahkonen N, Emani MR, Viitala M, Laurila K, Sahla R, Lund R, Lahdesmaki H, Jaakkola P, Lahesmaa R
(
A1 Journal article – refereed)

ESTOOLS Data@Hand: human stem cell gene expression resource (2013)
Nature Methods
Kong L, Aho K, Granberg K, Lund R, Jarvenpaa L, Seppala J, Gokhale P, Leinonen K, Hahne L, Makela J, Laurila K, Pukkila H, Narva E, Yli-Harja O, Andrews PW, Nykter M, Lahesmaa R, Roos C, Autio R
(
B1 Journal article)

Global Chromatin State Analysis Reveals Lineage-Specific Enhancers during the Initiation of Human T helper 1 and T helper 2 Cell Polarization (2013)
Immunity
Hawkins RD, Larjo A, Tripathi SK, Wagner U, Luu Y, Lönnberg T, Raghav SK, Lee LK, Lund R, Ren B, Lähdesmäki H, Lahesmaa R
(
A1 Journal article – refereed)


Last updated on 2019-22-08 at 02:18