Tero Aittokallio
PhD

professori, Matematiikka (Matematiikan ja tilastotieteen laitos)

teanai@utu.fi
+358 29 450 4321
+358 50 350 9623

Vesilinnantie 5
Turku





Biografia

Tero Aittokallio received his PhD in Applied Mathematics from the University of Turku in 2001, under the supervision of Prof. Mats Gyllenberg. He then did his post-doctoral training in the Systems Biology Lab at the Institut Pasteur (2006-2007), with Dr. Benno Schwikowski, where he focused on network biology applications using high-throughput experimental assays and network analysis tools such as Cytoscape. In 2007, Dr. Aittokallio launched his independent career as a principal investigator in the Turku Biomathematics Research Group, where he received a five-year appointment as an Academy of Finland Research Fellow (2007-2012). Tero Aittokallio joined Institute for Molecular Medicine Finland (FIMM) as EMBL Group Leader in the fall of 2011, and was selected as Professor of Statistics and Applied Mathematics at University of Turku in 2015.



Tutkimus

Aittokallio's research group focuses on developing and applying integrated computational-experimental approaches to tackle biomedical questions, such as how genes function as interaction networks to carry out and regulate cellular processes, how alterations in these networks contribute to complex traits, such as human diseases, and where and how in the disease network one should target to optimally inhibit the disease phenotypes, such as tumor growth.



Opetus

Computational statistics.

Scientific computing.



Julkaisut
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DNMT Inhibitors Increase Methylation in the Cancer Genome (2019)
Frontiers in Pharmacology
Giri AK, Aittokallio T
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Integrated analysis of drug sensitivity and selectivity to predict synergistic drug combinations and target coaddictions in cancer (2019) Systems Chemical Biology : Methods and protocols Jaiswal Alok, Yadav Bhagwan, Wennerberg Krister, Aittokallio Tero
(
A3 Kirjan tai muun kokoomateoksen osa)

Machine learning and feature selection for drug response prediction in precision oncology applications (2019) Ali Mehreen, Aittokallio Tero
(
A2 Katsausartikkeli tieteellisessä aikauslehdessä)

Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy (2019)
Nature Communications
Haikala HM, Anttila JM, Marques E, Raatikainen T, Ilander M, Hakanen H, Ala-Hongisto H, Savelius M, Balboa D, Von Eyss B, Eskelinen V, Munne P, Nieminen AI, Otonkoski T, Schuler J, Laajala TD, Aittokallio T, Sihto H, Mattson J, Heikkila P, Leidenius M, Joensuu H, Mustjoki S, Kovanen P, Eilers M, Leverson JD, Klefstrom J, Klefstrom J
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Adrenals Contribute to Growth of Castration-Resistant VCaP Prostate Cancer Xenografts (2018)
American Journal of Pathology
Huhtaniemi R, Oksala R, Knuuttila M, Mehmood A, Aho E, Laajala TD, Nicorici D, Aittokallio T, Laiho A, Elo L, Ohlsson C, Kallio P, Mäkelä S, Mustonen MVJ, Sipilä P, Poutanen M
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target (2018)
Nature Communications
Dufva O, Kankainen M, Kelkka T, Sekiguchi N, Awad SA, Eldfors S, Yadav B, Kuusanmaki H, Malani D, Andersson EI, Pietarinen P, Saikko L, Kovanen PE, Ojala T, Lee DA, Loughran TP, Nakazawa H, Suzumiya J, Suzuki R, Ko YH, Kim WS, Chuang SS, Aittokallio T, Chan WC, Ohshima K, Ishida F, Mustjoki S, Mustjoki S
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Antiandrogens Reduce Intratumoral Androgen Concentrations and Induce Androgen Receptor Expression in Castration-Resistant Prostate Cancer Xenografts (2018)
American Journal of Pathology
Knuuttila M, Mehmood A, Huhtaniemi R, Yatkin E, Häkkinen MR, Oksala R, Laajala TD, Ryberg H, Handelsman DJ, Aittokallio T, Auriola S, Ohlsson C, Laiho A, Elo LL, Sipilä P, Mäkelä SI, Poutanen M
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling (2018)
Leukemia
E I Andersson, S Pützer, B Yadav, O Dufva, S Khan, L He, L Sellner, A Schrader, G Crispatzu, M Oleś, H Zhang, S Adnan-Awad, S Lagström, D Bellanger, J P Mpindi, S Eldfors, T Pemovska, P Pietarinen, A Lauhio, K Tomska, C Cuesta-Mateos, E Faber, S Koschmieder, T H Brümmendorf, S Kytölä, E-R Savolainen, T Siitonen, P Ellonen, O Kallioniemi, K Wennerberg, W Ding, M-H Stern, W Huber, S Anders, J Tang, T Aittokallio, T Zenz, M Herling, S Mustjoki
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Drug-sensitivity screening and genomic characterization of 45 hpV-negative head and neck carcinoma cell lines for novel biomarkers of drug efficacy (2018)
Molecular Cancer Therapeutics
Tatiana Lepikhova, Piia-Riitta Karhemo, Riku Louhimo, Bhagwan Yadav, Astrid Murumägi, Evgeny Kulesskiy, Mikko Kivento, Harri Sihto, Reidar Grénman, Stina M. Syrjänen, Olli Kallioniemi, Tero Aittokallio, Krister Wennerberg, Heikki Joensuu, Outi Monni
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Drug Target Commons 2.0: a community platform for systematic analysis of drug target interaction profiles (2018)
Database: The Journal of Biological Databases and Curation
Ziaur Rehman Tanoli, Zaid Alam, Markus Vähä-Koskela, Balaguru Ravikumar, Alina Malyutina, Alok Jaiswal, Jing Tang, Krister Wennerberg, Tero Aittokallio
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions (2018)
Cell Chemical Biology
Jing Tang, Zia-ur-Rehman, Balaguru Raviku, Zaid Alam, Anni Rebane, Markus Vähä-Koskela, Gopal Peddinti, Arjan J. van drichem, Janica Wakkinen, Alok Jaiswal, Ella Karjalainen, Prson Gautam, Liye He, Elina Parri, Suleiman Khan, Abhishekh Gupta, Mehreen Ali, Laxman Yetukuri, Anna-Lena Gustavsson, Brinton Seashore-Ludlow, Anne Hersey, Andrew R. Leach, John P. Overington, Gretchen Repasky, Krister Wennerberg, Tero Aittokallio
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

ePCR: an R-package for survival and time-to-event prediction in advanced prostate cancer, applied to real-world patient cohorts (2018)
Bioinformatics
Laajala TD, Murtojärvi M, Virkki A, Aittokallio T
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Global proteomics profiling improves drug sensitivity prediction: results from a multi-omics, pan-cancer modeling approach (2018)
Bioinformatics
Mehreen Ali, Suleiman A. Khan, Krister Wennerberg, Tero Aittokallio
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML (2018)
Leukemia
Oscar Brück, Sami Blom, Olli Dufva, Riku Turkki, Himanshu Chheda, Antonio Ribeiro, Panu Kovanen, Tero Aittokallio, Perttu Koskenvesa, Olli Kallioniemi, Kimmo Porkka, Teijo Pellinen, Satu Mustjoki
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery (2018)
Expert Opinion on Drug Discovery
Ravikumar B., Aittokallio T.
(
A2 Katsausartikkeli tieteellisessä aikauslehdessä)

Interactive visual analysis of drug-target interaction networks using Drug Target Profiler, with applications to precision medicine and drug repurposing (2018)
Briefings in Bioinformatics
Tanoli Ziaurrehman, Alam Zaid, Ianevski Aleksandr, Wennerberg Krister, Vähä-Koskela Markus, Aittokallio Tero
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Learning with multiple pairwise kernels for drug bioactivity prediction (2018)
Bioinformatics
Cichonska A, Pahikkala T, Szedmak S, Julkunen H, Airola A, Heinonen M, Aittokallio T, Rousu J
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Methods for high-throughput drug combination screening and synergy scoring (2018) Cancer Systems Biology Liye He, Evgeny Kulesskiy, Jani Saarela, Laura Turunen, Krister Wennerberg, Tero Aittokallio, Jing Tang
(
A3 Kirjan tai muun kokoomateoksen osa)

Novel activities of safe-in-human broad-spectrum antiviral agents (2018)
Antiviral Research
Aleksandr Ianevski, Eva Zusinaite, Suvi Kuivanen, Mårten Strand, Hilde Lysvand, Mona Teppor, Laura Kakkola, Henrik Paavilainen, Mira Laajala, Hannimari Kallio-Kokko, Miia Valkonen, Anu Kantele, Kaidi Telling, Irja Lutsar, Pille Letjuka, Natalja Metelitsa, Valentyn Oksenych, Magnar Bjørås, Svein Arne Nordbø, Uga Dumpis, Astra Vitkauskiene, Christina Öhrmalm, Kåre Bondeson, Anders Bergqvist, Tero Aittokallio, Rebecca J. Cox, Magnus Evander, Veijo Hukkanen, Varpu Marjomaki, Ilkka Julkunen, Olli Vapalahti, Tanel Tenson, Andres Merits, Denis Kainov
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Patient-Customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients (2018)
Cancer Research
He LY, Tang J, Andersson EI, Timonen S, Koschmieder S, Wennerberg K, Mustjoki S, Aittokallio T
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)


Last updated on 2019-20-07 at 02:23