Eriika Savontaus


Assistant Professor, Institute of Biomedicine (Institute of Biomedicine)
Research Center for Intergrative Physiology and Pharmacology
erisan@utu.fi
+358 29 450 4659
+358 50 401 2195

Kiinamyllynkatu 10
Turku





Areas of expertise
pharmacology; drug therapeutics; obesity; diabetes; cardiovascular diseases, in vivo disease models

Biography

Eriika Savontaus received MD in 1995 and PhD in 1999 at University of Turku. She got her post-doctoral training at Columbia University, Division of Molecular Genetics, New York, NY, USA 2000-2002. She established her own laboratory in the Department of Pharmacology and Clinical Pharmacology in 2003. Savontaus received the title of docent in Pharmacology in 2008. She has served as Senior/Clinical Lecturer (9/03-9/05,  3/09-7/09, 2/15-5/17), acting Professor in Pharmacology (8/07-2/09) and Academy Research Fellow (1/07-7/07, 8/09-1/15). Savontaus started as an Assistant Professor (tenure track) of Pharmacology and Therapeutics in 6/2017. She has a part-time affiliation as a physician in Clinical Pharmacology in University Hospital of Turku.



Research

Obesity with related metabolic and cardiovascular diseases is an increasing problem, but current means to prevent and treat obesity are clearly insufficient. Research of Savontaus group aims to identifying novel means of intervention. The main interest is in two neuropeptides, NPY (neuropeptide Y) and POMC (melanocortins), that play key roles in the regulation of body weight.  They are working to understand the tissue-specific mechanisms of NPY and melanocortin action in order to facilitate drug development for metabolic and cardiovascular diseases. Furthermore, the aim is  to understand the impact of the genetics and epigenetics of these genes on the risk of cardiometabolic diseases and whether the epigenetic inheritance of metabolic diseases could be prevented.



Teaching

Eriika Savontaus is the responsible teacher in the courses of Pharmacology and Clinical Pharmacology. She is involved in organizing doctoral training as the director of Drug Research Doctoral Program. She has supervised PhD thesis of five doctoral candidates and Master's thesis of 11 students.



Publications
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Diabeteslääkkeet (2018) Farmakologia ja toksikologia Savontaus, E. Rouru, J.
(
D2 Article in a professional research book)

Diurnal rhythms of blood glucose, serum ghrelin, faecal IgA and faecal corticosterone in rats subjected to restricted feeding using the diet board (2018)
Laboratory Animals
Iiris Kasanen, Katja Inhilä, Eriika Savontaus, Hanna-Marja Voipio, Kai Õkva, Satu Mering, Vesa Kiviniemi, Jann Hau, Sakari Laaksonen, Timo Nevalainen
(
A1 Journal article – refereed)

Effects of dexmedetomidine and MK-467 on plasma glucose, insulin and glucagon in a glibenclamide-induced canine hypoglycaemia model (2018)
Veterinary Journal
Kallio-Kujala I., Bennett R., Raekallio M., Yatkin E., Meierjohann A., Savontaus E., Scheinin M., Spillmann T., Vainio O.
(
A1 Journal article – refereed)

Hypothalamic γ-melanocyte stimulating hormone gene delivery reduces fat mass in male mice (2018)
Journal of Endocrinology
Eerola K., Virtanen S., Vähätalo L., Ailanen L., Cai M., Hruby V., Savontaus M., Savontaus E.
(
A1 Journal article – refereed)

Increased Energy Expenditure, Lipolysis and Hyperinsulinemia Confer Resistance to Central Obesity and Type 2 Diabetes in Mice Lacking Alpha2α-Adrenoceptors (2018)
Neuroendocrinology
Ruohonen S, Valve L, Tuomainen K, Ailanen L, Röyttä M, Manz G, Baur N, Joos T, Savontaus E, Scheinin M
(
A1 Journal article – refereed)

Insuliini (2018) Farmakologia ja toksikologia Savontaus E, Rouru J
(
D2 Article in a professional research book)

JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche (2018)
Molecular Psychiatry
H Mohammad, F Marchisella, S Ortega-Martinez, P Hollos, K Eerola, E Komulainen, N Kulesskaya, E Freemantle, V Fagerholm, E Savontous, H Rauvala, B D Peterson, H van Praag, E T Coffey
(
A1 Journal article – refereed)

Melanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E-/- Mice (2018)
Arteriosclerosis, Thrombosis, and Vascular Biology
Petteri Rinne, James J. Kadiri, Mauricio Velasco-Delgado, Salla Nuutinen, Miro Viitala, Maija Hollmén, Martina Rami, Eriika Savontaus, Sabine Steffens
(
A1 Journal article – refereed)

Melanocortin overexpression limits diet-induced inflammation and atherosclerosis in LDLR-/- mice (2018)
Journal of Endocrinology
Nuutinen S, Ailanen L, Savontaus E, Rinne P
(
A1 Journal article – refereed)

Metformin normalizes the structural changes in glycogen preceding prediabetes in mice overexpressing neuropeptide Y in noradrenergic neurons (2018)
Pharmacology Research and Perspectives
Ailanen L, Bezborodkina NN, Virtanen L, Ruohonen ST, Malova AV, Okovityi SV, Chistyakova EY, Savontaus E
(
A1 Journal article – refereed)

Osteoporoosin hoidossa käytettävät lääkeaineet (2018) Farmakologia ja toksikologia Savontaus. E, Rouru, J.
(
D2 Article in a professional research book)

Peripherally Administered Y-2-Receptor Antagonist BIIE0246 Prevents Diet-Induced Obesity in Mice With Excess Neuropeptide Y, but Enhances Obesity in Control Mice (2018)
Frontiers in Pharmacology
Liisa Ailanen, Laura H. Vähätalo, Henriikka Salomäki-Myftari, Satu Mäkelä, Wendy Orpana, Suvi T. Ruohonen, Eriika Savontaus
(
A1 Journal article – refereed)

Vitamiinit (2018) Farmakologia ja toksikologia Freese R, Savontaus E.
(
D2 Article in a professional research book)

Diabetes, lihavuus ja metabolinen oireyhtymä (2017) Lääketieteellinen farmakologia ja toksikologia Savontaus Eriika, Huupponen Risto
(
D2 Article in a professional research book)

Endokriiniseen järjestelmään vaikuttavat lääkeaineet (2017) Lääketieteellinen farmakologia ja toksikologia Huupponen Risto, Savontaus Eriika
(
D2 Article in a professional research book)

Lääketieteellinen farmakologia ja toksikologia (2017) Heikki Ruskoaho, Jukka Hakkola, Risto Huupponen, Anu Kantele, Esa Korpi, Eeva Moilanen, Petteri Piepponen, Eriika Savontaus, Olli Tenhunen, Kirsi Vähäkangas
(
D6 Edited professional book)

The metabolic syndrome in mice overexpressing neuropeptide Y in noradrenergic neurons (2017)
Journal of Endocrinology
Ailanen L, Ruohonen ST, Vahatalo LH, Tuomainen K, Eerola K, Salomaki-Myftari H, Roytta M, Laiho A, Ahotupa M, Gylling H, Savontaus E
(
A1 Journal article – refereed)

Tyypin 2 diabeksen lääkevalikoima monipuolistuu - yhdistelmistä tehoa hoitoon (2017)
Diabetes ja lääkäri
Savontaus E
(
D1 Article in a trade journal)

Neuropeptide Y in noradrenergic neurons induces obesity in transgenic mouse models (2016)
Neuropeptides
Laura H. Vähätalo, Suvi T. Ruohonen, Liisa Ailanen, Eriika Savontaus
(
A2 Review article in a scientific journal)

Neuropeptide Y Overexpressing Female and Male Mice Show Divergent Metabolic but Not Gut Microbial Responses to Prenatal Metformin Exposure (2016)
PLoS ONE
Henriikka Salomäki-Myftari, Laura H. Vähätalo, Liisa Ailanen, Sami Pietilä, Asta Laiho, Arno Hänninen, Juha-Pekka Pursiheimo, Eveliina Munukka, Anniina Rintala, Eriika Savontaus, Ullamari Pesonen, Markku Koulu
(
A1 Journal article – refereed)


Last updated on 2019-19-08 at 02:19