Jorma Määttä
PhD., Adjunct Professor

University Lecturer, Institute of Biomedicine (Institute of Biomedicine)
Adjunct Professor, Faculty of Science and Engineering (Faculty of Science and Engineering)

jmaatta@utu.fi
+358 29 450 4466
+358 50 400 4219

Kiinamyllynkatu 10
Turku





Biography

Education and degrees completed
Doctor of Philosophy    17.8.1998, University of Turku, Medical Faculty
Master of Science         11.3.1993, University of Turku, Biotechnology
High school graduation    31.5.1987, Rauhala High School, Lieksa
Military service              13.6 1988 – 8.5.1989, SissiK/P-KR

Title of Docent        27.3.2006 Docent (Adjunct Professor) of Molecular Cell Biology, Institute of Biochemistry, University of Turku.

Other education   
21.6.2018 Official teacher’s qualification (decree 794/2004; 60 credits ECTS B), University of Turku, Faculty of Education Radiation safety principal, 2007, University of Helsinki

Current position    University Lecturer, Principal Investigator, University of Turku, Institute of Biomedicine 1.1.2018 -

Previous work experience
1.1.2016 – 31.12.2017    University Research Fellow at the University of Turku, Institute of Biomedicine
1.9.2011 – 31.12.2015    University Research Fellow at the University of Turku, Department of Cell Biology and Anatomy (50%) and the University of Eastern Finland, School of Pharmaceutics (50%)
1.9. 2007 – 31.8.2011    Senior Scientist, Bone Analysis Unit Manager of Turku Center for Disease Modeling
1.1.2006 – 31.8.2007    Senior Scientist, Professor Kalervo Väänänen’s research group, Department of Anatomy, University of Turku
1.9.2005 – 31.12.2005    Senior Scientist, Professor Pirkko Härkönen’s research group, Department of Anatomy, University of Turku
1.1.2004 – 31.8.2005    Senior Scientist, Docent Markku Salmivirta’s research group Turku Centre of Biotechnology
1.8.2003 – 31.12.2003    Postdoctoral Researcher in Docent Klaus Elenius’s research group, Medicity Research Laboratory, University of Turku
1.8.2002 – 31.7.2003    Postdoctoral Researcher of the Foundation of the Finnish Cancer Institute
1.8.1999 – 31.7.2002    Postdoctoral Researcher of the Academy of Finland
1.1.1999 – 31.12.2004    Postdoctoral Researcher in Docent Klaus Elenius’s research group, Medicity Research Laboratory, University of Turku
1.7.1998 – 31.12.1998    Research Fellow in Docent Ari Hinkkanen’s research group Department of Biochemistry and Pharmacy, Åbo Akademi University
1.2.1995 – 30.6.1998    Turku Post Graduate School of Biomed. Sciences, post graduate student
1.1.1993 – 31.1.1995    Research assistant, Department of Virology, University of Turku
1991, 1992, 1.6-31.8.    Research assistant, Department of Virology, University of Turku
4.6.1990 – 31.8.1990    Research assistant, Huhtamäki Oy Leiras Ltd. Biotechnological Research Laboratory



Research

In my research the function of myeloid cells in regulation of immune responses is evaluated. This includes chronic inflammations and autoimmunity as well as the role of tumor associated mac-rophages (TAMs) in maintaining an immunosuppressive status in the tumor microenvironment and promotion of cancer cell migration and invasion. Further, novel treatment modalities based either on hormone receptor signaling or the pleiotropic effects of bisphosphonate (induced) metabolites are being sought to modulate the function of the myeloid cell population more feasible for the patient.



Teaching

Teaching responsibilities include lecturing and contact teaching on the fields of molecular cell biology, histology and X-ray microtomography and imaging



Publications
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Inactivation of Estrogen Receptor Alpha in Bone Forming Cells Induces Bone Loss in Female Mice (2013)
FASEB Journal
Jorma A Määttä, Kalman G Büki, Guoliang Gu, Maria H Alanne, Jukka Vääräniemi, Heidi Liljenbäck, Matti Poutanen, Pirkko Härkönen, Kalervo Väänänen
(
A1 Journal article – refereed)

Inactivation of the androgen receptor in bone-forming cells leads to trabecular bone loss in adult female mice (2013)
BoneKEy Reports
Maatta JA, Buki KG, Ivaska KK, Nieminen-Pihala V, Elo TD, Kahkonen T, Poutanen M, Harkonen P, Vaananen K
(
A1 Journal article – refereed)

Maternal hyperglycemia leads to fetal cardiac hyperplasia and dysfunction in a rat model (2013)
AJP - Endocrinology and Metabolism
Lehtoranta L, Vuolteenaho O, Laine VJ, Koskinen A, Soukka H, Kytö V, Määttä J, Haapsamo M, Ekholm E, Räsänen J
(
A1 Journal article – refereed)

Phenotypic characterization of transgenic mice harboring Nf1+/- or Nf1-/- osteoclasts in otherwise Nf1+/+ background (2012)
Journal of Cellular Biochemistry
Alanne MH, Siljamaki E, Peltonen S, Vaananen K, Windle JJ, Parada LF, Maatta JA, Peltonen J
(
A1 Journal article – refereed)

Receptor tyrosine kinase inhibition causes simultaneous bone loss and excess bone formation within growing bone in rats. (2011)
Toxicology and Applied Pharmacology
Nurmio M, Joki H, Kallio J, Määttä JA, Väänänen HK, Toppari J, Jahnukainen K, Laitala-Leinonen T
(
A1 Journal article – refereed)

Removal of cell surface heparan sulfate increases TACE activity and cleavage of ErbB4 receptor (2009)
BMC Cell Biology
Maatta JA, Olli K, Henttinen T, Tuittila MT, Elenius K, Salmivirta M
(
A1 Journal article – refereed)

Suppression of breast cancer growth by a monoclonal antibody specifically targeting cleavable ErbB4 isoforms. (2009) Hollmén M, Määttä JA, Bald L, Sliwkowski MX, Elenius K.
(
A1 Journal article – refereed)

Differential nuclear localization and kinase activity of alternative ErbB4 intracellular domains (2007)
Oncogene
Sundvall M, Peri L, Määttä JA, Tvorogov D, Paatero I, Savisalo M, Silvennoinen O, Yarden Y, Elenius K
(
A1 Journal article – refereed)

Proteolytic cleavage and phosphorylation of tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth. (2006) Määttä J.A., Sundvall M., Junttila T.T., Peri L., Isola J., Egeblad M., Elenius K.
(
A1 Journal article – refereed)

Angiopoietin-regulated recruitment of vascular smooth muscle cells by endothelial-derived heparin binding EGF-like growth factor (2003) Iivanainen E, Nelimarkka L, Elenius V, Heikkinen S-M, Junttila TT, Sihombin L, Sundvall M, Määttä JA, Laine VJO, Higashiyama S, Alitalo K, Elenius K
(
A1 Journal article – refereed)

A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis (2000) Kainulainen V, Sundvall M, Määttä JA, Santiestevan E, Klagsbrun M, Elenius K
(
A1 Journal article – refereed)

Enhancement of EAE Severity by Ultrasound Emulsification of Antigen/Adjuvant in Distinct Strains of Mice (2000) Määttä JA, Nygårdas PT, Hinkkanen AE
(
A1 Journal article – refereed)

Erbb4 and its isoforms: selective regulation of growth factor responses by naturally occurring receptor variants (2000) Junttila TT, Sundvall M, Määttä JA, Elenius K
(
A1 Journal article – refereed)

Replicase complex genes of Semliki Forest virus confer lethal neurovirulence (2000) Tuittila MT, Santagati MG, Roytta M, Maatta JA, Hinkkanen AE
(
A1 Journal article – refereed)

Encephalitogenicity of myelin-associated oligodendrocytic basic protein and 2’, 3’-cyclic nucleotide 3’-phosphodiesterase for BALB/c and SJL mice (1998) Määttä JA, Käldman MS, Sakoda S, Salmi AA, Hinkkanen AE
(
A1 Journal article – refereed)

Neutrophils secreting tumor necrosis factor alpha infiltrate the CNS of BALB/c mice with EAE (1998) Määttä JA, Sjöholm UR, Nygårdas PT, Salmi AA, Hinkkanen AE
(
A1 Journal article – refereed)

The significance of the 3'-nontranslated region and E2 amino acid mutations in the virulence of Semliki Forest virus in mice (1998) Santagati MG, Maatta JA, Roytta M, Salmi AA, Hinkkanen AE
(
A1 Journal article – refereed)

Detection of myelin basic protein isoforms by organic concentration (1997) Määttä JA, Coffey ET, Hermonen JA, Salmi AA, Hinkkanen AE
(
A1 Journal article – refereed)

Physical stage of neuroantigen adjuvant determines encephalitogenicity in BALB/c mouse (1996) Määttä JA, Erälinna J-P, Salmi A, Hinkkanen EA
(
A1 Journal article – refereed)


Last updated on 2019-19-06 at 02:22