Jorma Määttä
PhD., Adjunct Professor

University Lecturer, Institute of Biomedicine (Institute of Biomedicine)
Adjunct Professor, Faculty of Science and Engineering (Faculty of Science and Engineering)

jmaatta@utu.fi
+358 29 450 4466
+358 50 400 4219

Kiinamyllynkatu 10
Turku





Biography

Education and degrees completed
Doctor of Philosophy    17.8.1998, University of Turku, Medical Faculty
Master of Science         11.3.1993, University of Turku, Biotechnology
High school graduation    31.5.1987, Rauhala High School, Lieksa
Military service              13.6 1988 – 8.5.1989, SissiK/P-KR

Title of Docent        27.3.2006 Docent (Adjunct Professor) of Molecular Cell Biology, Institute of Biochemistry, University of Turku.

Other education   
21.6.2018 Official teacher’s qualification (decree 794/2004; 60 credits ECTS B), University of Turku, Faculty of Education Radiation safety principal, 2007, University of Helsinki

Current position    University Lecturer, Principal Investigator, University of Turku, Institute of Biomedicine 1.1.2018 -

Previous work experience
1.1.2016 – 31.12.2017    University Research Fellow at the University of Turku, Institute of Biomedicine
1.9.2011 – 31.12.2015    University Research Fellow at the University of Turku, Department of Cell Biology and Anatomy (50%) and the University of Eastern Finland, School of Pharmaceutics (50%)
1.9. 2007 – 31.8.2011    Senior Scientist, Bone Analysis Unit Manager of Turku Center for Disease Modeling
1.1.2006 – 31.8.2007    Senior Scientist, Professor Kalervo Väänänen’s research group, Department of Anatomy, University of Turku
1.9.2005 – 31.12.2005    Senior Scientist, Professor Pirkko Härkönen’s research group, Department of Anatomy, University of Turku
1.1.2004 – 31.8.2005    Senior Scientist, Docent Markku Salmivirta’s research group Turku Centre of Biotechnology
1.8.2003 – 31.12.2003    Postdoctoral Researcher in Docent Klaus Elenius’s research group, Medicity Research Laboratory, University of Turku
1.8.2002 – 31.7.2003    Postdoctoral Researcher of the Foundation of the Finnish Cancer Institute
1.8.1999 – 31.7.2002    Postdoctoral Researcher of the Academy of Finland
1.1.1999 – 31.12.2004    Postdoctoral Researcher in Docent Klaus Elenius’s research group, Medicity Research Laboratory, University of Turku
1.7.1998 – 31.12.1998    Research Fellow in Docent Ari Hinkkanen’s research group Department of Biochemistry and Pharmacy, Åbo Akademi University
1.2.1995 – 30.6.1998    Turku Post Graduate School of Biomed. Sciences, post graduate student
1.1.1993 – 31.1.1995    Research assistant, Department of Virology, University of Turku
1991, 1992, 1.6-31.8.    Research assistant, Department of Virology, University of Turku
4.6.1990 – 31.8.1990    Research assistant, Huhtamäki Oy Leiras Ltd. Biotechnological Research Laboratory



Research

In my research the function of myeloid cells in regulation of immune responses is evaluated. This includes chronic inflammations and autoimmunity as well as the role of tumor associated mac-rophages (TAMs) in maintaining an immunosuppressive status in the tumor microenvironment and promotion of cancer cell migration and invasion. Further, novel treatment modalities based either on hormone receptor signaling or the pleiotropic effects of bisphosphonate (induced) metabolites are being sought to modulate the function of the myeloid cell population more feasible for the patient.



Teaching

Teaching responsibilities include lecturing and contact teaching on the fields of molecular cell biology, histology and X-ray microtomography and imaging



Publications
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Bone Marrow Niche: Role of Different Cells in Bone Metastasis (2018)
Current Molecular Biology Reports
Terhi J. Heino, Jorma A. Määttä
(
A2 Review article in a scientific journal)

Dicer1 ablation in osterix positive bone forming cells affects cortical bone homeostasis (2018)
BONE
Bendre A, Moritz N, Väänänen V, Määttä JA
(
A1 Journal article – refereed)

SERMs Promote Anti-Inflammatory Signaling and Phenotype of CD14+ Cells (2018)
Inflammation
Polari Lauri, Wiklund Anu, Sousa Sofia, Kangas Lauri, Linnanen Tero, Härkönen Pirkko, Määttä Jorma
(
A1 Journal article – refereed)

Tuumorimakrofaagit luumetastaasien muodostumisessa (2018)
BestPractice Onkologia ja hematologia
Jorma Määttä
(
D1 Article in a trade journal)

Fam3c modulates osteogenic differentiation by down-regulating Runx2 (2017)
Differentiation
Bendre Ameya, Büki Kalman G, Määttä Jorma A
(
A1 Journal article – refereed)

Selective Calcium-Dependent Inhibition of ATP-Gated P2X3 Receptors by Bisphosphonate-Induced Endogenous ATP Analog ApppI (2017)
Journal of Pharmacology and Experimental Therapeutics
Ishchenko Yevheniia, Shakirzyanova Anastasia, Giniatullina Raisa, Skorinkin Andrei, Bart Geneviev, Turhanen Petri, Määttä Jorma A, Monkkonen Jukka, Giniatullin Rashid
(
A1 Journal article – refereed)

Teriparatide Treatment in Patients With WNT1 or PLS3 Mutation-Related Early-Onset Osteoporosis: A Pilot Study (2017)
Journal of Clinical Endocrinology and Metabolism
Valimaki VV, Makitie O, Pereira R, Laine C, Wesseling-Perry K, Maatta J, Kirjavainen M, Viljakainen H, Valimaki MJ
(
A1 Journal article – refereed)

Butyrophilin 3A/CD277-Dependent Activation of Human γδ T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations (2016)
Journal of Immunology
Nerdal PT, Peters C, Oberg HH, Zlatev H, Lettau M, Quabius ES, Sousa S, Gonnermann D, Auriola S, Olive D, Määttä J, Janssen O, Kabelitz D
(
A1 Journal article – refereed)

Fam3c modulates osteogenic cell differentiation and affects bone volume and cortical bone mineral density (2016)
BoneKEy Reports
Määttä Jorma A., Bendre Ameya, Laanti Mervi, Buki Kalman G., Rantakari Pia, Tervola Paivi, Saarimäki Johanna, Poutanen Matti, Härkönen Pirkko, Väänänen Kalervo
(
A1 Journal article – refereed)

The role of tumour-associated macrophages in bone metastasis (2016)
Journal of Bone Oncology
Sousa Sofia, Määttä Jorma
(
A2 Review article in a scientific journal)

Tsoledronaatti toimii tehokkaasti rintasyöpäsoluissa liposomaalisena tai kalsiumiin sitoutuneena (2016)
BestPractice Onkologia ja hematologia
Jorma Määttä
(
O2 Other)

Uptake of free, calcium-bound and liposomal encapsulated nitrogen containing bisphosphonates by breast cancer cells (2016)
European Journal of Pharmaceutical Sciences
Zlatev HP, Auriola S, Monkkonen J, Maatta JA
(
A1 Journal article – refereed)

Human breast cancer cells educate macrophages toward the M2 activation status. (2015)
Breast Cancer Research
Sofia Sousa, Régis Brion, Minnamaija Lintunen, Pauliina Kronqvist, Jouko Sandholm, Jukka Mönkkönen, Heikki Joensuu, Dominique Heymann, Jorma Määttä
(
A1 Journal article – refereed)

Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells. (2015)
BMC Cancer
Sousa S, Auriola S, Mönkkönen J, Määttä J
(
A1 Journal article – refereed)

Macrophages and pathophysiology of bone cancers (2015) Bone Cencer: Primary Bone Cancer and Bone Metastasis, 2nd Ed. Sofia Sousa, Jorma A. Määttä
(
A3 Book chapter)

Neuropeptide Y in the noradrenergic neurones induces obesity and inhibits sympathetic tone in mice. – Noradrenergic neurone NPY and obesity (2015)
Acta Physiologica
Vähätalo LH, Ruohonen ST, Mäkelä S, Kovalainen M, Huotari A, Mäkelä KA, Määttä JA, Miinalainen I, Gilsbach R, Hein L, Ailanen L, Mattila M, Eerola K, Röyttä M, Ruohonen S, Herzig KH, Savontaus E
(
A1 Journal article – refereed)

Overexpression of spermidine/spermine N1-acetyltransferase impairs osteoblastogenesis and alters mouse bone phenotype. (2015)
Transgenic Research
Pirnes-Karhu S, Määttä J, Finnilä M, Alhonen L, Uimari A.
(
A1 Journal article – refereed)

Upregulation of the mevalonate pathway by cholesterol depletion abolishes tolerance to N-bisphosphonate induced Vγ9Vδ2 T cell cytotoxicity in PC-3 prostate cancer cells (2015)
Cancer Letters
Arkko S, Zlatev HP, Mönkkönen H, Räikkönen J, Benzaïd I, Clézardin P, Mönkkönen J, Määttä JA.
(
A1 Journal article – refereed)

Probenecid as a sensitizer of bisphosphonate-mediated effects in breast cancer cells. (2014)
Molecular Cancer
Ebert R, Meissner-Weigl J, Zeck S, Määttä J, Auriola S, Coimbra de Sousa S, Mentrup B, Graser S, Rachner TD, Hofbauer LC, Jakob F.
(
A1 Journal article – refereed)

Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages. (2013)
Journal of Experimental Medicine
Kiviranta R, Yamana K, Saito H, Ho DK, Laine J, Tarkkonen K, Nieminen-Pihala V, Hesse E, Correa D, Määttä J, Tessarollo L, Rosen ED, Horne WC, Jenkins NA, Copeland NG, Warming S, Baron R
(
A1 Journal article – refereed)


Last updated on 2019-26-05 at 02:18