Jorma Määttä
PhD., Adjunct Professor
Turun tautimallinnuskeskus TCDM jmaatta@utu.fi +358 29 450 4466 +358 50 400 4219 Kiinamyllynkatu 10 Turku Office: C411 ORCID identifier: https://orcid.org/0000-0001-8752-6862 |
myeloid cells; chronic inflammation; sex steroid receptor; bone biology; tumor macrophage; bioimaging
Education and degrees completed
Doctor of Philosophy 17.8.1998, University of Turku, Medical Faculty
Master of Science 11.3.1993, University of Turku, Biotechnology
High school graduation 31.5.1987, Rauhala High School, Lieksa
Military service 13.6 1988 – 8.5.1989, SissiK/P-KR
Title of Docent 27.3.2006 Docent (Adjunct Professor) of Molecular Cell Biology, Institute of Biochemistry, University of Turku.
Other education
21.6.2018 Official teacher’s qualification (decree 794/2004; 60 credits ECTS B), University of Turku, Faculty of Education Radiation safety principal, 2007, University of Helsinki
Current position University Lecturer, Principal Investigator, University of Turku, Institute of Biomedicine 1.1.2018 -
Previous work experience
1.1.2016 – 31.12.2017 University Research Fellow at the University of Turku, Institute of Biomedicine
1.9.2011 – 31.12.2015 University Research Fellow at the University of Turku, Department of Cell Biology and Anatomy (50%) and the University of Eastern Finland, School of Pharmaceutics (50%)
1.9. 2007 – 31.8.2011 Senior Scientist, Bone Analysis Unit Manager of Turku Center for Disease Modeling
1.1.2006 – 31.8.2007 Senior Scientist, Professor Kalervo Väänänen’s research group, Department of Anatomy, University of Turku
1.9.2005 – 31.12.2005 Senior Scientist, Professor Pirkko Härkönen’s research group, Department of Anatomy, University of Turku
1.1.2004 – 31.8.2005 Senior Scientist, Docent Markku Salmivirta’s research group Turku Centre of Biotechnology
1.8.2003 – 31.12.2003 Postdoctoral Researcher in Docent Klaus Elenius’s research group, Medicity Research Laboratory, University of Turku
1.8.2002 – 31.7.2003 Postdoctoral Researcher of the Foundation of the Finnish Cancer Institute
1.8.1999 – 31.7.2002 Postdoctoral Researcher of the Academy of Finland
1.1.1999 – 31.12.2004 Postdoctoral Researcher in Docent Klaus Elenius’s research group, Medicity Research Laboratory, University of Turku
1.7.1998 – 31.12.1998 Research Fellow in Docent Ari Hinkkanen’s research group Department of Biochemistry and Pharmacy, Åbo Akademi University
1.2.1995 – 30.6.1998 Turku Post Graduate School of Biomed. Sciences, post graduate student
1.1.1993 – 31.1.1995 Research assistant, Department of Virology, University of Turku
1991, 1992, 1.6-31.8. Research assistant, Department of Virology, University of Turku
4.6.1990 – 31.8.1990 Research assistant, Huhtamäki Oy Leiras Ltd. Biotechnological Research Laboratory
In my research, the function of myeloid cells and mesenchymal cells in the process of calvarial implant integration (ADMIO-consortium). Further, we study also the role of sex steroid receptors on regulation of myeloid cells. This includes the role of myeloid cells in chronic inflammations (e.g. chronic colitis) as well as in tumors.
Teaching responsibilities include lecturing and contact teaching on the fields of (molecular) cell biology and histology for medical, biomedical and dentistry students
- Bioactive glasses promote rapid pre-osteoblastic cell migration in contrast to hydroxyapatite, while carbonated apatite shows migration inhibiting properties (2023)
- Scientific Reports
(Refereed journal article or data article (A1)) - CD73 regulates zoledronate-induced lymphocyte infiltration in triple-negative breast cancer tumors and lung metastases (2023)
- Frontiers in Immunology
(Refereed journal article or data article (A1)) - Liposome-encapsulated zoledronate increases inflammatory macrophage population in TNBC tumours (2023)
- European Journal of Pharmaceutical Sciences
(Refereed journal article or data article (A1)) - Distinctive effects of SGLT2 inhibitors on angiogenesis in zebrafish embryos (2022)
- Biomedicine and Pharmacotherapy
(Refereed journal article or data article (A1)) - Macrophages and pathophysiology of bone cancers (2022) Bone Cancer, Bone Sarcomas and Bone Metastases - From Bench to Bedside Sousa Sofia, Määttä Jorma
(Refereed article in compilation book (A3)) - Signature of circulating small non-coding RNAs during early fracture healing in mice (2022)
- Bone Reports
(Refereed journal article or data article (A1)) - Inhibition of STAT3 prevents bone metastatic progression of prostate cancer in vivo (2021)
- Prostate
(Refereed journal article or data article (A1)) - Multiple targets identified with genome wide profiling of small RNA and mRNA expression are linked to fracture healing in mice (2021)
- Bone Reports
(Refereed journal article or data article (A1)) - Biomaterial and implant induced ossification: in vitro and in vivo findings (2020)
- Journal of Tissue Engineering and Regenerative Medicine
(Refereed journal article or data article (A1)) - Novel Selective Estrogen Receptor Modulator Ameliorates Murine Colitis (2019)
- International Journal of Molecular Sciences
(Refereed journal article or data article (A1)) - Bone Marrow Niche: Role of Different Cells in Bone Metastasis (2018)
- Current Molecular Biology Reports
(Refereed review article in scientific journal (A2)) - Dicer1 ablation in osterix positive bone forming cells affects cortical bone homeostasis (2018)
- BONE
(Refereed journal article or data article (A1)) - SERMs Promote Anti-Inflammatory Signaling and Phenotype of CD14+ Cells (2018)
- Inflammation
(Refereed journal article or data article (A1)) - Tuumorimakrofaagit luumetastaasien muodostumisessa (2018)
- BestPractice Onkologia ja hematologia
(Article in trade journal or blog post (D1)) - Fam3c modulates osteogenic differentiation by down-regulating Runx2 (2017)
- Differentiation
(Refereed journal article or data article (A1)) - Selective Calcium-Dependent Inhibition of ATP-Gated P2X3 Receptors by Bisphosphonate-Induced Endogenous ATP Analog ApppI (2017)
- Journal of Pharmacology and Experimental Therapeutics
(Refereed journal article or data article (A1)) - Teriparatide Treatment in Patients With WNT1 or PLS3 Mutation-Related Early-Onset Osteoporosis: A Pilot Study (2017)
- Journal of Clinical Endocrinology and Metabolism
(Refereed journal article or data article (A1)) - Butyrophilin 3A/CD277-Dependent Activation of Human γδ T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations (2016)
- Journal of Immunology
(Refereed journal article or data article (A1)) - Fam3c modulates osteogenic cell differentiation and affects bone volume and cortical bone mineral density (2016)
- BoneKEy Reports
(Refereed journal article or data article (A1)) - The role of tumour-associated macrophages in bone metastasis (2016)
- Journal of Bone Oncology
(Refereed review article in scientific journal (A2))