Eeva-Liisa Eskelinen
PhD

Professor, Institute of Biomedicine (Institute of Biomedicine)

eeva-liisa.eskelinen@utu.fi
+358 29 450 3996
+358 50 511 5631



Medisiina
Office: C305
Kiinamyllynkatu 10, 20520 Turku, Finland
Medisiina C305


Areas of expertise
Cell biology, autophagy, lysosomes, electron microscopy, cell imaging

Biography

Eeva-Liisa Eskelinen has a long track record in autophagy field, in particular, in  elucidating the fine structure and membrane dynamics of autophagosomes and autolysosomes using electron microscopy. She completed her PhD in 1993 at the University of Jyväskylä, Finland. After that, she worked as postdoctoral researcher in Göttingen, Germany and Helsinki, Finland. Then she moved to Dundee, Scotland, where she worked as an independent investigator (1999-2002). From Scotland she moved to Kiel, Germany to work as a group leader in the department headed by professor Paul Saftig (2002-2005). In August 2005 she started as a University Lecturer at the Department of Biosciences, University of Helsinki.

Finally, 1st of November 2017 she started as a Professor in medical cell biology at the Institute of Biomedicine, University of Turku, Finland.



Research

Membrane dynamics in autophagy

Autophagy is a lysosomal degradation pathway for cytoplasmic material and organelles that maintains cellular homeostasis during nutrient deprivation and stress. Autophagy also contributes to the clearance of damaged organelles and aggregate-prone proteins, protection against metabolic stress and DNA damage, and even to longevity of the organism. Defective autophagy has been connected to many human diseases including cancer, myopathies, metabolic diseases, and neurodegenerative diseases.

In macroautophagy, autophagosomes are formed in a subcompartment of the endoplasmic reticulum. A flat membrane cistern called the phagophore emerges first, which then elongates and forms a double-membrane bound autophagosome. Autophagosomes acquire hydrolytic capacity by fusing with endosomes and lysosomes. The origin of phagophore and autophagosome membranes is one of the longest lasting open questions in the field. We address this question using three-dimensional electron microscopy, live-cell imaging and correlative light-electron microscopy.

In addition, we study the molecular mechanisms of RAB24, a GTPas that functions in the late phase of the macroautophagic pahtway.



Teaching

Eeva-Liisa Eskelinen is the responsible teacher of the course cell and tissue biology (SKB), aimed for first year students of medicine, dentistry and biomedicine. She is also teaching electron microscopy methods on the MSc Program on Biomedical Imaging.



Publications
Go to first page Go to previous page 1 of 4 Go to next page Go to last page

A Computer-Vision-Guided Robot Arm for Automatically Placing Grids in Pioloform Film Preparation (2019) Peurla Markus, Hänninen Pekka, Eskelinen Eeva-Liisa
(
A1 Journal article – refereed)

Autophagy, Inflammation, and Metabolism (AIM) Center in its second year (2019)
Autophagy
Deretic V, Prossnitz E, Burge M, Campen MJ, Cannon J, Liu KJ, Hall P, Sklar LA, Allers L, Mariscal L, Garcia SA, Baehrecke EH, Behrends C, Cecconi F, Codogno P, Elazar Z, Chen GC, Fourie B, Eskelinen EL, Hong W, Gozuacik D, Johansen T, Jo EK, Kimchi A, Juhász G, Kroemer G, Ktistakis N, Münz C, Mizushima N, Rubinsztein D, Reggiori F, Shen HM, Simonsen A, Ryan K, Schroder K, Yoshimori T, Yu L, Tooze SA, Vaccaro M, Zhang H, Klionsky DJ
(
B1 Journal article)

Autophagy: supporting cellular and organismal homeostasis by self-eating (2019)
International Journal of Biochemistry and Cell Biology
Eskelinen EL
(
A2 Review article in a scientific journal)

Correlative Light and Electron Microscopy of Autophagosomes (2019) Autophagy: Methods and Protocols Gudmundsson S, Kahlhofer J, Baylac N, Kallio K, Eskelinen E-L
(
B2 Book chapter)

Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy (2019)
Autophagy
Claudine Kraft, Patricia Boya, Patrice Codogno, Zvulun Elazar, Eeva-Liisa Eskelinen, Judith Farrés, Vladimir Kirkin, Heinz Jungbluth, Ana Martinez, Ole Pless, Charlotte Primard, Tassula Proikas-Cezanne, Anne Simonsen, Fulvio Reggiori
(
B1 Journal article)

ER-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of ULK1 and ULK2 Kinases (2019)
Cells
Anwar Tahira, Liu Xiaonan, Suntio Taina, Marjamäki Annika, Biazik Joanna, Chan Edmond Y. W., Varjosalo Markku, Eskelinen Eeva-Liisa
(
A1 Journal article – refereed)

Alterations of autophagy in the peripheral neuropathy Charcot-Marie-Tooth type 2B (2018)
Autophagy
Colecchia D, Stasi M, Leonardi M, Manganelli F, Nolano M, Veneziani BM, Santoro L, Eskelinen EL, Chiariello M, Bucci C
(
A1 Journal article – refereed)

Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations (2018)
Autophagy
Vojo Deretic, Eric Prossnitz, Mark Burge, Matthew J. Campen, Judy Cannon, Ke Jian Liu, Larry A. Sklar, Lee Allers, Sally Ann Garcia, Eric H. Baehrecke, Christian Behrends, Francesco Cecconi, Patrice Codogno, Guang-Chao Chen, Zvulun Elazar, Eeva-Liisa Eskelinen, Bernard Fourie, Devrim Gozuacik, Wanjin Hong, Gokhan Hotamisligi, Marja Jäättelä, Eun-Kyeong Jo, Terje Johansen, Gábor Juhász, Adi Kimchi, Nicholas Ktistakis, Guido Kroemer, Noboru MIzushima, Christian Münz, Fulvio Reggiori, David Rubinsztein, Kevin Ryan, Kate Schroder, Anne Simonsen, Sharon Tooze, Maria I. Vaccaro, Tamotsu Yoshimori, Li Yu, Hong Zhang, Daniel J. Klionsky
(
B1 Journal article)

Deficit in PINK1/PARKIN-mediated mitochondrial autophagy at late stages of dystrophic cardiomyopathy (2018)
Cardiovascular Research
Kang CF, Badr MA, Kyrychenko V, Eskelinen EL, Shirokova N
(
A1 Journal article – refereed)

GIMAP6 is required for T cell maintenance and efficient autophagy in mice (2018)
PLoS ONE
John C. Pascall, Louise M. C. Webb, Eeva-Liisa Eskelinen, Silvia Innocentin, Noudjoud Attaf-Bouabdallah, Geoffrey W. Butcher
(
A1 Journal article – refereed)

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis (2018)
Nature Communications
Carroll B, Otten EG, Manni D, Stefanatos R, Menzies FM, Smith GR, Jurk D, Kenneth N, Wilkinson S, Passos JF, Attems J, Veal EA, Teyssou E, Seilhean D, Millecamps S, Eskelinen EL, Bronowska AK, Rubinsztein DC, Sanz A, Korolchuk VI
(
A1 Journal article – refereed)

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing (2018)
Nature Reviews Drug Discovery
Barry Boland, Wai Haung Yu, Olga Corti, Bertrand Mollereau, Alexandre Henriques, Erwan Bezard, Greg M. Pastores, David C. Rubinsztein, Ralph A. Nixon, Michael R. Duchen, Giovanna R. Mallucci, Guido Kroemer, Beth Levine, Eeva-Liisa Eskelinen, Fanny Mochel, Michael Spedding, Caroline Louis, Olivier R. Martin, Mark J. Millan
(
A2 Review article in a scientific journal)

Roles for RAB24 in autophagy and disease (2018)
Small GTPases
Ylä-Anttila P., Eskelinen E.
(
A2 Review article in a scientific journal)

Vacuole membrane protein 1 marks endoplasmic reticulum subdomains enriched in phospholipid synthesizing enzymes and is required for phosphoinositide distribution (2018)
Traffic
Tabara LC, Vicente JJ, Biazik J, Eskelinen EL, Vincent O, Escalante R
(
A1 Journal article – refereed)

2BC Non-Structural Protein of Enterovirus A71 Interacts with SNARE Proteins to Trigger Autolysosome Formation (2017)
Viruses
Lai JKF, Sam IC, Verlhac P, Baguet J, Eskelinen EL, Faure M, Chan YF
(
A1 Journal article – refereed)

Basal Autophagy Is Altered in Lagotto Romagnolo Dogs with an ATG4D Mutation (2017)
Veterinary Pathology
Syrjä P., Anwar T., Jokinen T., Kyöstilä K., Jäderlund K.H., Cozzi F., Rohdin C., Hahn K., Wohlsein P., Baumgartner W., Henke D., Oevermann A., Sukura A., Leeb T., Lohi H., Eskelinen E-L.
(
A1 Journal article – refereed)

Calpain mobilizes Atg9/Bif-1 vesicles from Golgi stacks upon autophagy induction by thapsigargin (2017)
Biology Open
Marcassa Elena, Raimondi Marzia, Anwar Tahira, Eskelinen Eeva-Liisa, Myers Michael P., Triolo Gianluca, Schneider Claudio, Demarchi Francesca
(
A1 Journal article – refereed)

Depletion of TM6SF2 disturbs membrane lipid composition and dynamics in HuH7 hepatoma cells (2017)
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
Hanna Ruhanen, P.A. Nidhina Haridas, Eeva-Liisa Eskelinen, Ove Eriksson, Vesa M. Olkkonen, Reijo Käkelä
(
A1 Journal article – refereed)

Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes (2017)
Autophagy
Kissing S, Rudnik S, Damme M, Lullmann-Rauch R, Ichihara A, Kornak U, Eskelinen EL, Jabs S, Heeren J, De Brabander JK, Haas A, Saftig P
(
A1 Journal article – refereed)

Foreword: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging (2017) Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging Eeva-Liisa Eskelinen
(
B2 Book chapter)


Last updated on 2019-17-07 at 02:22