Olli Pentikäinen
PhD

Professor, Institute of Biomedicine (Institute of Biomedicine)

olli.pentikainen@utu.fi
+358 40 521 6913

Kiinamyllynkatu 10
Turku




Areas of expertise
Computer-Dependent Drug Discovery; Molecular Modeling; Protein structure-function relationship; Protein-protein interaction

Biography
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)

Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)


Research
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.

Publications
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Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives (2018)
Journal of Enzyme Inhibition and Medicinal Chemistry
Niinivehmas S, Postila PA, Rauhamaki S, Manivannan E, Kortet S, Ahinko M, Huuskonen P, Nyberg N, Koskimies P, Latti S, Multamaki E, Juvonen RO, Raunio H, Pasanen M, Huuskonen J, Pentikainen OT
(
A1 Journal article – refereed)

Development of new Coumarin-based profluorescent substrates for human cytochrome P450 enzymes (2018)
Xenobiotica
Juvonen R., Ahinko M., Huuskonen J., Raunio H., Pentikäinen O.
(
A1 Journal article – refereed)

Discovery of Retinoic Acid-Related Orphan Receptor gamma t Inverse Agonists via Docking and Negative Image-Based Screening (2018)
ACS Omega
Sanna Rauhamäki, Pekka A. Postila, Sakari Lätti, Sanna Niinivehmas, Elina Multamäki, Klaus R. Liedl, Olli T. Pentikäinen
(
A1 Journal article – refereed)

Effects of cold acclimation and dsRNA injections on Gs1l gene splicing in Drosophila montana (2018)
Scientific Reports
Hopkins D, Envall T, Poikela N, Pentikäinen OT, Kankare M
(
A1 Journal article – refereed)

Improving Docking Performance Using Negative Image-Based (2018)
Frontiers in Pharmacology
Sami T. Kurkinen, Sanna Niinivehmas, Mira Ahinko, Sakari Lätti, Olli T. Pentikäinen, Pekka A. Postila
(
A1 Journal article – refereed)

Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10 (2018)
Molecular Pharmaceutics
Risto O. Juvonen , Sanna Rauhamäki, Sami Kortet, Sanna Niinivehmas, Johanna Troberg, Aleksanteri Petsalo, Juhani Huuskonen, Hannu Raunio, Moshe Finel, Olli T. Pentikäinen
(
A1 Journal article – refereed)

Structure-Activity Relationship Analysis of 3-Phenylcoumarin-Based Monoamine Oxidase B Inhibitors (2018)
Frontiers in Chemistry
Sanna Rauhamäki, Pekka A. Postila, Sanna Niinivehmas, Sami Kortet, Emmi Schildt, Mira Pasanen, Elangovan Manivannan, Mira Ahinko, Pasi Koskimies, Niina Nyberg, Pasi Huuskonen, Elina Multamäki, Markku Pasanen, Risto O. Juvonen, Hannu Raunio, Juhani Huuskonen, Olli T. Pentikäinen
(
A1 Journal article – refereed)

Suitability of MMGBSA for the selection of correct ligand binding modes from docking results (2018)
Chemical Biology and Drug Design
Mira Ahinko, Sanna Niinivehmas, Elmeri Jokinen, Olli T. Pentikäinen
(
A1 Journal article – refereed)

Identification of the Privileged Position in the Imidazo[1,2-a]pyridine Ring of Phosphonocarboxylates for Development of Rab Geranylgeranyl Transferase (RGGT) Inhibitors (2017)
Journal of Medicinal Chemistry
Kaźmierczak Aleksandra, Kusy Damian, Niinivehmas Sanna, Gmach Joanna, Joachimiak Łukasz, Pentikäinen Olli, Gendaszewska-Darmach Edyta, Blazewska Katarzyna
(
A1 Journal article – refereed)

Skeletal Dysplasia Mutations Effect on Human Filamins' Structure and Mechanosensing (2017)Seppala J, Bernardi RC, Haataja TJK, Hellman M, Pentikainen OT, Schulten K, Permi P, Ylanne J, Pentikainen U
(
A1 Journal article – refereed)

Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes (2016)
Xenobiotica
Juvonen RO, Kuusisto M, Fohrgrup C, Pitkanen MH, Nevalainen TJ, Auriola S, Raunio H, Pasanen M, Pentikainen OT
(
A1 Journal article – refereed)

The Influence of Hydrogen Bonding on Sphingomyelin/Colipid Interactions in Bilayer Membranes (2016)
Biophysical Journal
Yasuda T, Al Sazzad MA, Jantti NZ, Pentikainen OT, Slotte JP
(
A1 Journal article – refereed)

Case-specific performance of MM-PBSA, MM-GBSA, and SIE in virtual screening (2015)
Journal of Molecular Graphics and Modelling
Virtanen SI, Niinivehmas SP, Pentikainen OT
(
A1 Journal article – refereed)

Case-specific performance of MM-PBSA, MM-GBSA, and SIE in virtual screening (2015)
Journal of Molecular Graphics and Modelling
Virtanen SI, Niinivehmas SP, Pentikainen OT
(
A1 Journal article – refereed)

Case-specific performance of MM-PBSA, MM-GBSA, and SIE in virtual screening (2015)
Journal of Molecular Graphics and Modelling
Virtanen SI, Niinivehmas SP, Pentikainen OT
(
A1 Journal article – refereed)

Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes (2015)
Frontiers in Pharmacology
Raunio H, Kuusisto M, Juvonen RO, Pentikainen OT
(
A1 Journal article – refereed)

Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes (2015)
Frontiers in Pharmacology
Raunio H, Kuusisto M, Juvonen RO, Pentikainen OT
(
A1 Journal article – refereed)

Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes (2015)
Frontiers in Pharmacology
Raunio H, Kuusisto M, Juvonen RO, Pentikainen OT
(
A1 Journal article – refereed)

Ultrafast protein structure-based virtual screening with Panther (2015)
Journal of Computer-Aided Molecular Design
Niinivehmas SP, Salokas K, Latti S, Raunio H, Pentikainen OT
(
A1 Journal article – refereed)

Ultrafast protein structure-based virtual screening with Panther (2015)
Journal of Computer-Aided Molecular Design
Niinivehmas SP, Salokas K, Latti S, Raunio H, Pentikainen OT
(
A1 Journal article – refereed)


Last updated on 2019-21-02 at 01:24