Olli Pentikäinen
PhD

Adjunct Professor, Faculty of Science and Engineering (Faculty of Science and Engineering)
Professor, Institute of Biomedicine (Institute of Biomedicine)

olli.pentikainen@utu.fi
+358 40 521 6913

Kiinamyllynkatu 10
Turku




Areas of expertise
Computer-Dependent Drug Discovery; Molecular Modeling; Protein structure-function relationship; Protein-protein interaction

Biography
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)

Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)


Research
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.

Publications

Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives (2018)
Journal of Enzyme Inhibition and Medicinal Chemistry
Niinivehmas S, Postila PA, Rauhamaki S, Manivannan E, Kortet S, Ahinko M, Huuskonen P, Nyberg N, Koskimies P, Latti S, Multamaki E, Juvonen RO, Raunio H, Pasanen M, Huuskonen J, Pentikainen OT
(
A1 Journal article – refereed)

Discovery of Retinoic Acid-Related Orphan Receptor gamma t Inverse Agonists via Docking and Negative Image-Based Screening (2018)
ACS Omega
Sanna Rauhamäki, Pekka A. Postila, Sakari Lätti, Sanna Niinivehmas, Elina Multamäki, Klaus R. Liedl, Olli T. Pentikäinen
(
A1 Journal article – refereed)

Effects of cold acclimation and dsRNA injections on Gs1l gene splicing in Drosophila montana (2018)
Scientific Reports
Hopkins D, Envall T, Poikela N, Pentikäinen OT, Kankare M
(
A1 Journal article – refereed)

Improving Docking Performance Using Negative Image-Based (2018)
Frontiers in Pharmacology
Sami T. Kurkinen, Sanna Niinivehmas, Mira Ahinko, Sakari Lätti, Olli T. Pentikäinen, Pekka A. Postila
(
A1 Journal article – refereed)

Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10 (2018)
Molecular Pharmaceutics
Risto O. Juvonen , Sanna Rauhamäki, Sami Kortet, Sanna Niinivehmas, Johanna Troberg, Aleksanteri Petsalo, Juhani Huuskonen, Hannu Raunio, Moshe Finel, Olli T. Pentikäinen
(
A1 Journal article – refereed)

Structure-Activity Relationship Analysis of 3-Phenylcoumarin-Based Monoamine Oxidase B Inhibitors (2018)
Frontiers in Chemistry
Sanna Rauhamäki, Pekka A. Postila, Sanna Niinivehmas, Sami Kortet, Emmi Schildt, Mira Pasanen, Elangovan Manivannan, Mira Ahinko, Pasi Koskimies, Niina Nyberg, Pasi Huuskonen, Elina Multamäki, Markku Pasanen, Risto O. Juvonen, Hannu Raunio, Juhani Huuskonen, Olli T. Pentikäinen
(
A1 Journal article – refereed)

Identification of the Privileged Position in the Imidazo[1,2-a]pyridine Ring of Phosphonocarboxylates for Development of Rab Geranylgeranyl Transferase (RGGT) Inhibitors (2017)
Journal of Medicinal Chemistry
Kaźmierczak Aleksandra, Kusy Damian, Niinivehmas Sanna, Gmach Joanna, Joachimiak Łukasz, Pentikäinen Olli, Gendaszewska-Darmach Edyta, Blazewska Katarzyna
(
A1 Journal article – refereed)

Skeletal Dysplasia Mutations Effect on Human Filamins' Structure and Mechanosensing (2017)Seppala J, Bernardi RC, Haataja TJK, Hellman M, Pentikainen OT, Schulten K, Permi P, Ylanne J, Pentikainen U
(
A1 Journal article – refereed)

Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes (2016)
Xenobiotica
Juvonen RO, Kuusisto M, Fohrgrup C, Pitkanen MH, Nevalainen TJ, Auriola S, Raunio H, Pasanen M, Pentikainen OT
(
A1 Journal article – refereed)

The Influence of Hydrogen Bonding on Sphingomyelin/Colipid Interactions in Bilayer Membranes (2016)
Biophysical Journal
Yasuda T, Al Sazzad MA, Jantti NZ, Pentikainen OT, Slotte JP
(
A1 Journal article – refereed)

A Novel Structural Unit in the N-terminal Region of Filamins (2014)
Journal of Biological Chemistry
Sethi R, Seppala J, Tossavainen H, Ylilauri M, Ruskamo S, Pentikainen OT, Pentikainen U, Permi P, Ylanne J
(
A1 Journal article – refereed)

L-Arabinose/D-galactose 1-dehydrogenase of Rhizobium leguminosarum bv. trifolii characterised and applied for bioconversion of L-arabinose to L-arabonate with Saccharomyces cerevisiae (2014)
Applied Microbiology and Biotechnology
Aro-Karkkainen N, Toivari M, Maaheimo H, Ylilauri M, Pentikainen OT, Andberg M, Oja M, Penttila M, Wiebe MG, Ruohonen L, Koivula A
(
A1 Journal article – refereed)

Molecular mechanism of T-cell protein tyrosine phosphatase (TCPTP) activation by mitoxantrone (2013)
BBA - Biochimica et Biophysica Acta
Mikko Ylilauri, Elina Mattila, Elisa M Nurminen, Jarmo Käpylä, Sanna P Niinivehmas, Juha A Määttä, Ulla Pentikäinen, Johanna Ivaska, and Olli T Pentikäinen
(
A1 Journal article – refereed)

Novel alpha 2 beta 1 Integrin Inhibitors Reveal That Integrin Binding to Collagen under Shear Stress Conditions Does Not Require Receptor Preactivation (2012)
Journal of Biological Chemistry
Nissinen L, Koivunen J, Kapyla J, Salmela M, Nieminen J, Jokinen J, Sipila K, Pihlavisto M, Pentikainen OT, Marjamaki A, Heino J
(
A1 Journal article – refereed)

Fluorescent Small Molecule Probe to Modulate and Explore alpha 2 beta 1 Integrin Function (2011)
Journal of the American Chemical Society
Koivunen JT, Nissinen L, Kapyla J, Jokinen J, Pihlavisto M, Marjamaki A, Heino J, Huuskonen J, Pentikainen OT
(
A1 Journal article – refereed)

Novel Hydrazine Molecules as Tools To Understand the Flexibility of Vascular Adhesion Protein-1 Ligand-Binding Site: Toward More Selective Inhibitors (2011)
Journal of Medicinal Chemistry
Nurminen EM, Pihlavisto M, Lazar L, Pentikainen U, Fulop F, Pentikainen OT
(
A1 Journal article – refereed)

Synthesis, in Vitro Activity, and Three-Dimensional Quantitative Structure-Activity Relationship of Novel Hydrazine Inhibitors of Human Vascular Adhesion Protein-1 (2010)
Journal of Medicinal Chemistry
Nurminen EM, Pihlavisto M, Lazar L, Szakonyi Z, Pentikainen U, Fulop F, Pentikainen OT
(
A1 Journal article – refereed)

Cooperative symmetric to asymmetric conformational transition of the apo-form of scavenger decapping enzyme revealed by simulations (2008)
Proteins
Pentikainen U, Pentikainen OT, Mulholland AJ
(
A1 Journal article – refereed)

Determination of binding site residues responsible for the subunit selectivity of novel marine-derived compounds on kainate receptors (2006)
Molecular Pharmacology
Sanders JM, Pentikainen OT, Settimo L, Pentikainen U, Shoji M, Sasaki M, Sakai R, Johnson MS, Swanson GT
(
A1 Journal article – refereed)

Vascular amine oxidases are needed for leukocyte extravasation into inflamed joints in vivo (2006)
Arthritis and Rheumatism
Marttila-Ichihara F, Smith DJ, Stolen C, Yegutkin GG, Elima K, Mercier N, Kiviranta R, Pihlavisto M, Alaranta S, Pentikainen U, Pentikainen O, Fulop F, Jalkanen S, Salmi M
(
A1 Journal article – refereed)


Last updated on 2018-27-09 at 02:20