Noora Kotaja
PhD, Associate Professor

Associate Professor, Institute of Biomedicine (Institute of Biomedicine)

nookot@utu.fi
+358 29 450 4639
+358 50 477 3367

Kiinamyllynkatu 10
Turku
Medisiina C5
Office: C539



Areas of expertise
Male fertility; spermatogenesis; male germ cells; gene regulation; RNA regulation; non-coding RNAs; paternal epigenetic inheritance

Biography

Noora Kotaja is an Associate Professor of Molecular
Medicine at the Institute of Biomedicine, University of Turku, Finland. She
obtained PhD in Biomedicine at the University of Helsinki under supervision of
Profs. Olli Jänne and Jorma Palvimo. The title of her PhD thesis was
"Function of PIAS proteins in steroid receptor-dependent signaling" ,
and it was approved with distinction and awarded with PhD theseis award from
the Finnish Academy of Science.She did her postdoctoral training at the
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg,
France, in the research group of Dr. Paolo Sassone-Corsi on germ cell-specific
regulation of gene expression. In 2006, she returned back in Finland to
establish her own research group at the University of Turku, where she received
first an Academy Research Fellow post from the Academy of Finland, followed by
a tenure track Professor position in 2012. Her scientific achievements have
been recognized by L'Oreal Finland for Women in Science award in 2006, Unto
Uotila award form the Finnish Endrocrine Society in 2008 and Young Researcher
award from the International Netwolrk of Young Researchers in Male Fertiliy in
2011 and Yourn Andrologist award from the International Society of Andrology in
2013.



Research

Noora Kotaja's research focuses on the mechanisms of spermatogenesis and
germline-mediated epigenetic inheritance. In particular, her research group is
interested in the epigenetic and posttranscriptional regulation of gene
expression in meiotic and post-meiotic male germ cells, and the role of large
germ cell-specific ribonucleoprotein granules (germ granules) in the control of
germ cell's transcriptome. The research in the Kotaja group combines experimental animal studies
with human cohort studies to elucidate key epigenetic processes required for
the production of fertile spermatozoa and correct transgenerational
transmission of epigenetic information. The research may provide important
novel insights into the development of diagnosis, treatment and prevention
strategies for male infertility. Importantly, the research will also clarify the
mechanisms of epigenetic inheritance, which could help us to understand and
potentially prevent the transmission of acquired diseases such as metabolic
disorders. 



Teaching
  1. Molecular biology
  2. Biomedical research methods
  3. Reproductive biology


Publications
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Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction (2019)
Nature Communications
Zhang FP, Malinen M, Mehmood A, Lehtiniemi T, Jääskeläinen T, Niskanen EA, Korhonen H, Laiho A, Elo LL, Ohlsson C, Kotaja N, Poutanen M, Sipilä P, Palvimo JJ
(
A1 Journal article – refereed)

Transcription Factor USF1 Is Required for Maintenance of Germline Stem Cells in Male Mice (2019)
Endocrinology
Faisal I., Cisneros-Montalvo S., Hamer G., Tuominen M., Laurila P., Tumiati M., Jauhiainen M., Kotaja N., Toppari J., Mäkelä J-A., Kauppi L.
(
A1 Journal article – refereed)

Cilia-related protein SPEF2 regulates osteoblast differentiation (2018)
Scientific Reports
Lehti MS, Henriksson H, Rummukainen P, Wang F, Uusitalo-Kylmala L, Kiviranta R, Heino TJ, Kotaja N, Sironen A
(
A1 Journal article – refereed)

Exonuclease Domain-Containing 1 Enhances MIWI2 piRNA Biogenesis via Its Interaction with TDRD12 (2018)
Cell Reports
Radha Raman Pandey, David Homolka, Opeyemi Olotu, Ravi Sachidanandam, Noora Kotaja, Ramesh S.Pillai
(
A1 Journal article – refereed)

Germ granule-mediated RNA regulation in male germ cells (2018)
Reproduction
Tiina Lehtiniemi, Noora Kotaja
(
A2 Review article in a scientific journal)

Hydroxysteroid (17β) dehydrogenase 1 expressed by Sertoli cells contributes to steroid synthesis and is required for male fertility (2018)
FASEB Journal
Janne Hakkarainen, Fu-Ping Zhang, Heli Jokela, Artur Mayerhofer, Rüdiger Behr, Sheyla Cisneros-Montalvo, Mirja Nurmio, Jorma Toppari, Claes Ohlsson, Noora Kotaja, Petra Sipilä, and Matti Poutanen
(
A1 Journal article – refereed)

FYCO1 and autophagy control the integrity of the haploid male germ cell-specific RNP granules (2017)
Autophagy
Da Ros M, Lehtiniemi T, Olotu O, Fischer D, Zhang FP, Vihinen H, Jokitalo E, Sironen A, Toppari J, Kotaja N.
(
A1 Journal article – refereed)

SPEF2 functions in microtubule-mediated transport in elongating spermatids to ensure proper male germ cell differentiation (2017)
Development
Lehti MS, Zhang FP, Kotaja N, Sironen A
(
A1 Journal article – refereed)

The Genetics of Postmeiotic Male Germ Cell Differentiation from Round Spermatids to Mature Sperm (2017) Genetics of Human Infertility Lehtiniemi T., Kotaja N.
(
A3 Book chapter)

DICER Regulates the Formation and Maintenance of Cell-Cell Junctions in the Mouse Seminiferous Epithelium. (2015)
Biology of Reproduction
Korhonen HM, Yadav RP, Da Ros M, Chalmel F, Zimmermann C, Toppari J, Nef S, Kotaja N.
(
A1 Journal article – refereed)

KIF1-binding protein interacts with KIF3A in haploid male germ cells (2015)
Reproduction
Lehti MS, Kotaja N, Sironen A
(
A1 Journal article – refereed)

microRNA in Human Reproduction (2015) microRNA: Medical Evidence Iris Eisenberg, Noora Kotaja, Debra Goldman-Wohl, Tal Imbar
(
A3 Book chapter)

piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis (2015)
Genes and Development
Goh WSS, Falciatori I, Tam OH, Burgess R, Meikar O, Kotaja N, Hammell M, Hannon GJ
(
A1 Journal article – refereed)

Retromer vesicles interact with RNA granules in haploid male germ cells (2015)
Molecular and Cellular Endocrinology
Da Ros M, Hirvonen N, Olotu O, Toppari J, Kotaja N.
(
A1 Journal article – refereed)

An atlas of chromatoid body components (2014)
RNA
Meikar O, Vagin VV, Chalmel F, Sõstar K, Lardenois A, Hammell M, Jin Y, Da Ros M, Wasik KA, Toppari J, Hannon GJ, Kotaja N
(
A1 Journal article – refereed)

Germ Cell-Specific Targeting of DICER or DGCR8 Reveals a Novel Role for Endo-siRNAs in the Progression of Mammalian Spermatogenesis and Male Fertility (2014)
PLoS ONE
Zimmermann C, Romero Y, Warnefors M, Bilican A, Borel C, Smith LB, Kotaja N, Kaessmann H, Nef S
(
A1 Journal article – refereed)

Isolation of chromatoid bodies from mouse testis as a rich source of short RNAs (2014) Animal Endo-siRNAs Meikar O, Kotaja N.
(
A3 Book chapter)

MicroRNAs and spermatogenesis (2014)
Fertility and Sterility
Kotaja N
(
A2 Review article in a scientific journal)

Retinoblastoma protein (RB) interacts with E2F3 to control terminal differentiation of Sertoli cells (2014)
Cell Death and Disease
Rotgers E, Rivero-Müller A, Nurmio M, Parvinen M, Guillou F, Huhtaniemi I, Kotaja N, Bourguiba-Hachemi S, Toppari J
(
A1 Journal article – refereed)

Small RNAs in spermatogenesis (2014)
Molecular and Cellular Endocrinology
Yadav RP, Kotaja N
(
A2 Review article in a scientific journal)


Last updated on 2019-20-07 at 02:21