Pasi Virta
Professor

Professor, Laboratory of Organic Chemistry and Chemical Biology (Department of Chemistry)

pamavi@utu.fi
+358 29 450 3209
+358 50 328 5719

Vatselankatu 2
Turku





Areas of expertise
Synthesis of oligonucleotide, peptide nucleic acid, peptide (including antibodies) and carbohydrate conjugates, Drug delivery strategies of oligonucleotides, mechanistic studies of higher order secondary structures of nucleic acids, 19F NMR spectroscopy, DNA-templated synthesis, aqueous glycosylation

Publications
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Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin (2019)
Scientific Reports
Rosenqvist P, Palmu K, Prajapati RK, Yamada K, Niemi J, Belogurov GA, Metsa-Ketela M, Virta P
(
A1 Journal article – refereed)

Noninvasive and Quantitative Monitoring of the Distributions and Kinetics of MicroRNA-Targeting Molecules in Vivo by Positron Emission Tomography (2019)
Molecular Pharmaceutics
Jussi Mäkilä, Anu Kiviniemi, Tiina Saanijoki, Heidi Liljenbäck, Meeri Käkelä, Satish Jadhav, Päivi Poijärvi-Virta, Harri Lönnberg, Tiina Laitala-Leinonen, Pasi Virta, Anne Roivainen
(
A1 Journal article – refereed)

Synthesis of an Alkyne-Modified Bleomycin Disaccharide Precursor, Conversion to a F-18-Labeled Radiotracer, and Preliminary in vivo-PET Imaging Studies (2019)
European Journal of Organic Chemistry
Sajal K. Maity, Cheng-Bin Yim, Satish Jadhav, Alejandra Verhassel, Johanna Tuomela, Olof Solin, Tove J. Grönroos, Pasi Virta
(
A1 Journal article – refereed)

Synthesis of Glycosidic (beta-1 ''-> 6,3 ' and 4 ') Site Isomers of Neomycin B and Their Effect on RNA and DNA Triplex Stability (2019)
Molecules
Granqvist Lotta, Tähtinen Ville, Virta Pasi
(
A1 Journal article – refereed)

DNA-Templated N(Me)-Alkoxyamine Glycosylation (2018)
Organic Letters
Tommi Österlund, Heidi Korhonen, Pasi Virta
(
A1 Journal article – refereed)

Synthesis and Applicability of Base-Discriminating DNA-Triplex-Forming 19F NMR Probes (2018)
European Journal of Organic Chemistry
Bhuma N., Tähtinen V., Virta P.
(
A1 Journal article – refereed)

Synthesis of Azide-Modified Chondroitin Sulfate Precursors: Substrates for "Click"-Conjugation with Fluorescent Labels and Oligonucleotides (2018)
Bioconjugate Chemistry
Jadhav S, Gulumkar V, Deshpande P, Coffey ET, Lonnberg H, Virta P
(
A1 Journal article – refereed)

Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics (2017)
ACS Chemical Biology
Kaisa Palmu, Petja Rosenqvist, Keshav Thapa, Yulia Ilina, Vilja Siitonen, Bikash Baral, Janne Mäkinen, Georgi Belogurov, Pasi Virta, Jarmo Niemi, Mikko Metsä-Ketelä
(
A1 Journal article – refereed)

DNA barcoding reveals widespread occurrence of Leptidea juvernica (Lepidoptera: Pieridae) in southern Finland (2017)
Entomologisk tidskrift
Samuli Lehtonen, Ilari Lehtonen, Anssi Teräs, Juha Varrela, Pasi Virta, Eero J. Vesterinen
(
A1 Journal article – refereed)

F-19 NMR Spectroscopic Analysis of the Binding Modes in Triple-Helical Peptide Nucleic Acid (PNA)/MicroRNA Complexes (2017)
Chemistry - A European Journal
Tahtinen Ville, Granqvist Lotta, Murtola Merita, Stromberg Roger, Virta Pasi
(
A1 Journal article – refereed)

Synthesis of Aminoglycoside-2 '-O-Methyl Oligoribonucleotide Fusions (2017)
Molecules
Granqvist L, Kraszewski A, Tähtinen V, Virta P
(
A1 Journal article – refereed)

Zinc Ion-Dependent Peptide Nucleic Acid-Based Artificial Enzyme that Cleaves RNABulge Size and Sequence Dependence (2017)
Molecules
Murtola M, Ghidini A, Virta P, Stromberg R
(
A1 Journal article – refereed)

Characterization of G-quadruplex/hairpin transitions of RNA by 19F NMR spectroscopy (2016)
Chemistry - A European Journal
Lotta Granqvist, Pasi Virta
(
A1 Journal article – refereed)

In-Vivo Bone-Targeting of Bis(phosphonate)-Conjugated Double Helical RNA Monitored by Positron Emission Tomography (2016)
Molecular Pharmaceutics
Satish Jadhav, Meeri Käkelä, Matthieu Bourgery, Kiira Rimpilä, Heidi Liljenbäck, Riikka Siitonen, Jussi Mäkilä, Tiina Laitala-Leinonen, Päivi Poijärvi-Virta, Harri Lönnberg, Anne Roivainen, Pasi Virta
(
A1 Journal article – refereed)

Solid-supported porphyrins useful for the synthesis of conjugates with oligomeric biomolecules (2016)
Bioconjugate Chemistry
Satish Jadhav, Cheng-Bin Yim, Johan Rajander, Tove J. Grönroos, Olof Solin, Pasi Virta
(
A1 Journal article – refereed)

Synthesis and In Vivo PET Imaging of Hyaluronan Conjugates of Oligonucleotides (2016)
Bioconjugate Chemistry
Satish Jadhav, Meeri Käkelä, Jussi Mäkilä, Max Kiugel, Heidi Liljenbäck, Jenni Virta, Päivi Poijärvi-Virta, Tiina Laitala-Leinonen, Ville Kytö, Sirpa Jalkanen, Antti Saraste, Anne Roivainen, Harri Lönnberg, Pasi Virta
(
A1 Journal article – refereed)

2 '-O-[(4-CF3-triazol-1-yl)methyl] Uridine - A Sensitive F-19 NMR Sensor for the Detection of RNA Secondary Structures (2015)
Journal of Organic Chemistry
Granqvist L, Virta P
(
A1 Journal article – refereed)

Assembly of short oligoribonucleotides from commercially available building blocks on a tetrapodal soluble support (2015)
Current Organic Synthesis
Alejandro Gimenez Molina, Amit M. Jabgunde, Pasi Virta, Harri Lönnberg
(
A1 Journal article – refereed)

Preparation of a disulfide-linked precipitative soluble support for solution-phase synthesis of trimeric oligodeoxyribonucleotide 3´-(2-chlorophenylphosphate) building blocks (2015)
Beilstein Journal of Organic Chemistry
Amit M. Jabgunde, Alejandro Gimenez Molina, Pasi Virta, Harri Lönnberg
(
A1 Journal article – refereed)


Last updated on 2019-16-09 at 02:24