Jonne Laurila
PhD, Associate professor in pharmacology
jomila@utu.fi +358 40 065 5159 Kiinamyllynkatu 10 Turku ORCID identifier: https://orcid.org/https://orcid.org/0000-0002-0354-8640 |
My research focuses on the molecular pharmacology of human alpha2-adrenoceptors and octopamine receptors of the barnacle Balanus improvisus.
Octopamine receptors of insects represent counterparts of the adrenoceptors in vertebrate animals. The alpha2-adrenoceptor agonist medetomidine, known as a veterinary sedative agent, was discovered to inhibit the settling process of barnacles by inducing hyperactivity in the barnacle larvae. Our goal is to find compounds that activates only octopamine receptors of the Balanus improvisus but not the alpha2-adrenoceptors of vertebrates. These compounds could act as an antifouling agents. For this purpose we have developed novel cell-based screening and profiling assays to identify selective compounds for these receptors.
In addition, our interest is to study the ligand binding properties at human alpha2-adrenoceptors. For this purpose we have cell lines expressing the three subtypes of human alpha2-adrencoeptors.
- A Revised Pedagogy Model for Simulator-Based Training with Biomedical Laboratory Science Students (2021)
- Education Sciences
(Refereed journal article or data article (A1)) - Deciphering Imidazoline Off-Targets by Fishing in the Class A of GPCR field (2020)
- Molecular Informatics
(Refereed journal article or data article (A1)) - Learning Impact of a Virtual Brain Electrical Activity Simulator Among Neurophysiology Students: Mixed-Methods Intervention Study (2020)
- JMIR serious games
(Refereed journal article or data article (A1)) - A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin (2016)
- Bioorganic and Medicinal Chemistry
(Refereed journal article or data article (A1)) - Transfer of SAR information from hypotensive indazole to indole derivatives acting at alpha-adrenergic receptors: In vitro and in vivo studies (2016)
- European Journal of Medicinal Chemistry
(Refereed journal article or data article (A1)) - Fluorinated analogues of marsanidine, a highly α2-AR/imidazoline I1 binding site-selective hypotensive agent. Synthesis and biological activities. (2014)
- European Journal of Medicinal Chemistry
(Refereed journal article or data article (A1)) - Synthesis and biological activities of 2- [(heteroaryl)methyl]imidazolines (2012)
- Bioorganic and Medicinal Chemistry
(Refereed journal article or data article (A1)) - 3-[(Imidazolidin-2-yl)imino]indazole ligands with selectivity for the ?2-adrenoceptor compared to the imidazoline I1 receptor (2011)
- Bioorganic and Medicinal Chemistry
(Refereed journal article or data article (A1)) - Involvement of the first transmembrane segment of human alpha(2)-adrenoceptors in the subtype-selective binding of chlorpromazine, spiperone and spiroxatrine (2011)
- British Journal of Pharmacology
(Refereed journal article or data article (A1)) - Homogeneous GTP binding assay employing QRET technology (2010)
- Journal of Biomolecular Screening
(Refereed journal article or data article (A1)) - Octopamine receptors from the barnacle Balanus improvisus are activated by the α2-adrenoceptor agonist medetomidine (2010)
- Molecular Pharmacology
(Refereed journal article or data article (A1))