Matti Poutanen
PhD

Professor, Institute of Biomedicine (Institute of Biomedicine)

matpou@utu.fi
+358 29 450 2632
+358 50 366 0140

Kiinamyllynkatu 10
Turku
Office: C507




Areas of expertise
gentically modified mice, sex steroids, endometriosis, hormonal cancer

Biography

EDUCATIONAL
TRAINING



1987, M.Sc., Department of Biochemistry, University of
Oulu, Finland



1993, Ph.D., Department of Clinical Chemistry,
University of Oulu, Finland         



1997, Title of Docent
(Adjunct professor); Biochemical Endocrinology, University of Oulu, Finland   




CURRENT
POSITIONS



Professor, Department of Physiology,
University of Turku, and Director of Turku Center for Disease Modeling,
University of Turku, Finland



Senior Scientist
lecturer, Institute of Medicine, The Sahlgrenska Academy, Gothenburg
University, Gothenburg, Sweden

MAJOR GRANTS:
Academy
of Finland, The Finnish Cancer Organisations, Sigrid Juselius Foundation, Novo
Foundation, Vetenskaps Rådet, Business Finland and Industry

SUPERVISION OF STUDENTS: 30 PhD students supervised, 6 in training.



SCIENTIFIC
AND SOCIETAL IMPACT OFD THE WORK



Research
is mainly focused on sex steroid synthesis and action, with total number of
citation 6270 (Web of Science, April 2018); number of citations in 2017: ~400;
average citations per article: 26.8; h-index: 46; 182 original peer-reviewed
publications; 5 publications in high-impact journals (I.F. ≥ 10): J. Clin. Invest. 2x (I.F. 13), Cell Metab.(I.F. 17), Nat. Med. (I.F.
28), Gut (I.F. 14)



 Co-founder, Forendo
Pharma ltd (www.forendo.com) focusing on hormonal therapies for endometriosis
and male hypogonadism. The company has closed its investment rounds with the
leading Nordic start-up investors Karolinska Development AB, Novo Seeds and
Finnvera. 



Research
Our research group has been internationally in a key position in
providing evidence for the concept where the ligand concentration available for
steroid hormone receptor binding is markedly regulated by the target tissue
metabolism, termed intracrine steroid
hormone action
. The concept has proven to be essential for the growth and
progression of both prostate and breast cancer. We, furthermore, have shown
this concept to be valid also in premenopausal women, eg. in the endometriosis,
and other medically relevant implications are expected to rise in the near
future.


Teaching

Teaching experience in, endocrinology, developmental biology, hormonal cancer, GM mice and animal models and in vivo imaging



Publications
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Androgen receptor SUMOylation regulates bone mass in male mice (2019)
Molecular and Cellular Endocrinology
Jianyao Wu, Sofia Movérare-Skrtic, Fu-Ping Zhang, Antti Koskela, Juha Tuukkanen, Jorma J. Palvimo, Petra Sipilä, Matti Poutanen, Claes Ohlsson
(
A1 Journal article – refereed)

Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction (2019)
Nature Communications
Zhang FP, Malinen M, Mehmood A, Lehtiniemi T, Jääskeläinen T, Niskanen EA, Korhonen H, Laiho A, Elo LL, Ohlsson C, Kotaja N, Poutanen M, Sipilä P, Palvimo JJ
(
A1 Journal article – refereed)

Simultaneous analysis by LC-MS/MS of 22 ketosteroids with hydroxylamine derivatization and underivatized estradiol from human plasma, serum and prostate tissue (2019)
Journal of Pharmaceutical and Biomedical Analysis
Häkkinen MR, Murtola T, Voutilainen R, Poutanen M, Linnanen T, Koskivuori J, Lakka T, Jääskeläinen J, Auriola S
(
A1 Journal article – refereed)

Adrenals Contribute to Growth of Castration-Resistant VCaP Prostate Cancer Xenografts (2018)
American Journal of Pathology
Huhtaniemi R, Oksala R, Knuuttila M, Mehmood A, Aho E, Laajala TD, Nicorici D, Aittokallio T, Laiho A, Elo L, Ohlsson C, Kallio P, Mäkelä S, Mustonen MVJ, Sipilä P, Poutanen M
(
A1 Journal article – refereed)

Analysis by LC-MS/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue (2018)
Journal of Pharmaceutical and Biomedical Analysis
Häkkinen MR, Heinosalo T, Saarinen N, Linnanen T, Voutilainen R, Lakka T, Jääskeläinen J, Poutanen M, Auriola S
(
A1 Journal article – refereed)

Animal Models for Human Endocrine Disorders: Preface (2018)
Best Practice and Research: Clinical Endocrinology and Metabolism
Poutanen M, Tena-Sempere M
(
B1 Journal article)

Antiandrogens Reduce Intratumoral Androgen Concentrations and Induce Androgen Receptor Expression in Castration-Resistant Prostate Cancer Xenografts (2018)
American Journal of Pathology
Knuuttila M, Mehmood A, Huhtaniemi R, Yatkin E, Häkkinen MR, Oksala R, Laajala TD, Ryberg H, Handelsman DJ, Aittokallio T, Auriola S, Ohlsson C, Laiho A, Elo LL, Sipilä P, Mäkelä SI, Poutanen M
(
A1 Journal article – refereed)

Decidualization of Human Endometrial Stromal Fibroblasts is a Multiphasic Process Involving Distinct Transcriptional Programs (2018)
Reproductive Sciences
Rytkönen KT, Erkenbrack EM, Poutanen M, Elo LL, Pavlicev M, Wagner GP
(
A1 Journal article – refereed)

Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria (2018)
Nucleic Acids Research
Hilander T, Zhou XL, Konovalova S, Zhang FP, Euro L, Chilov D, Poutanen M, Chihade J, Wang ED, Tyynismaa H
(
A1 Journal article – refereed)

HSD17B1 expression induces inflammation-aided rupture of mammary gland myoepithelium (2018)
Endocrine-Related Cancer
Päivi Järvensivu, Taija Heinosalo, Janne Hakkarainen, Pauliina Kronqvist, Niina Saarinen, Matti Poutanen
(
A1 Journal article – refereed)

Hydroxysteroid (17 beta) dehydrogenase 13 deficiency triggers hepatic steatosis and inflammation in mice (2018)
FASEB Journal
Adam M, Heikelä H, Sobolewski C, Portius D, Mäki-Jouppila J, Mehmood A, Adhikari P, Esposito I, Elo LL, Zhang FP, Ruohonen ST, Strauss L, Foti M, Poutanen M
(
A1 Journal article – refereed)

Hydroxysteroid (17β) dehydrogenase 1 expressed by Sertoli cells contributes to steroid synthesis and is required for male fertility (2018)
FASEB Journal
Janne Hakkarainen, Fu-Ping Zhang, Heli Jokela, Artur Mayerhofer, Rüdiger Behr, Sheyla Cisneros-Montalvo, Mirja Nurmio, Jorma Toppari, Claes Ohlsson, Noora Kotaja, Petra Sipilä, and Matti Poutanen
(
A1 Journal article – refereed)

Hyperthyroidism and Papillary Thyroid Carcinoma in Thyrotropin Receptor D633H Mutant Mice (2018)
Thyroid
Holger Jaeschke, Henriette Undeutsch, Konrad Patyra, Christoffer Löf, Markus Eszlinger, Moosa Khalil, Meeri Jännäri, Kristiina Makkonen, Jorma Toppari, Fu-Ping Zhang, Matti Poutanen, Ralf Paschke, Jukka Kero
(
A1 Journal article – refereed)

Inducible Wnt16 inactivation: WNT16 regulates cortical bone thickness in adult mice (2018)
Journal of Endocrinology
Claes Ohlsson, Petra Henning, Karin H. Nilsson, Jianyao Wu, Karin L. Gustafsson, Klara Sjögren, Anna Törnqvist, Antti Koskela, Fu-Ping Zhang, Marie K. Lagerquist, Matti Poutanen, Juha Tuukkanen, Ulf H. Lerner, Sofia Movérare-Skrtic
(
A1 Journal article – refereed)

Insights into the role of androgen receptor in human testicular peritubular cells (2018)
Andrology
C. Mayer, M. Adam, L. Walenta, N. Schmid, H. Heikelä, K. Schubert, F. Flenkenthaler, K.-G. Dietrich, S. Gruschka, G. J. Arnold, T. Fröhlich, J. U. Schwarzer, F. M. Köhn, L. Strauss, H. Welter, M. Poutanen, A. Mayerhofer
(
A1 Journal article – refereed)

Intratumoral androgen levels are linked to TMPRSS2-ERG fusion in prostate cancer (2018)
Endocrine-Related Cancer
Knuuttila M, Mehmood A, Maki-Jouppila J, Ryberg H, Taimen P, Knaapila J, Ettala O, Bostrom PJ, Ohlsson C, Venalainen MS, Laiho A, Elo LL, Sipila P, Makela SI, Poutanen M
(
A1 Journal article – refereed)

Metabolic regulation of female puberty via hypothalamic AMPK-kisspeptin signaling (2018)
Proceedings of the National Academy of Sciences of the United States of America
Juan Roa, Alexia Barroso, Francisco Ruiz-Pino, Maria Jesus Vázquez, Patricia Seoane-Collazo, Noelia Martínez-Sanchez, David García-Galiano, Tuncay Ilhan, Rafael Pineda, Silvia León, Maria Manfredi-Lozano, Violeta Heras, Matti Poutanen, Juan M. Castellano, Francisco Gaytan, Carlos Diéguez, Leonor Pinilla, Miguel López, Manuel Tena-Sempere
(
A1 Journal article – refereed)

NLRP3 in somatic non-immune cells of rodent and primate testes (2018)
Reproduction
Walenta L, Schmid N, Schwarzer JU, Kohn FM, Urbanski HF, Behr R, Strauss L, Poutanen M, Mayerhofer A
(
A1 Journal article – refereed)

Partial thyrocyte-specific Gαs deficiency leads to rapid-onset hypothyroidism, hyperplasia, and papillary thyroid carcinoma-like lesions in mice (2018)
FASEB Journal
Konrad Patyra, Holger Jaeschke, Christoffer Löf, Meeri Jännäri, Suvi T. Ruohonen, Henriette Undeutsch, Moosa Khalil, Andreina Kero, Matti Poutanen, Jorma Toppari, Min Chen, Lee S. Weinstein, Ralf Paschke, Jukka Kero
(
A1 Journal article – refereed)

Role of hydroxysteroid (17beta) dehydrogenase type 1 in reproductive tissues and hormone-dependent diseases (2018)
Molecular and Cellular Endocrinology
Heinosalo T., Saarinen N., Poutanen M.
(
A2 Review article in a scientific journal)


Last updated on 2019-24-05 at 02:19