Riku Kiviranta
Assistant Professor in Endocrinology and Metabolic Diseases, Consultant in Endocrinology

apulaisprofessori, Sisätautioppi (Kliininen laitos)

rikkiv@utu.fi







Asiantuntijuusalueet
Endocrinology, Skeletal biology, Bone metabolism, Metabolic bone diseases, Osteoporosis, Cancer, Sarcoma, Molecular biology, Signaling, Epigenetics

Biografia
Dr. Kiviranta graduated as an M.D. at the University of Turku in 2010 and received his Ph.D.  at the Department of Medical Biochemistry and Genetics , University of Turku in 2014  After a year of clinical work in the Department of Medicine at the Turku University Hospital he joined professor Roland Baron’s research group as a postdoctoral fellow at the Yale University School of Medicine, New Haven, CT, USA in 2015 until 2017. In 2018 professor Baron was recruited to Harvard School of Dental Medicine, Harvard University, Boston, MA, USA, and Dr. Kiviranta continued his postdoctoral work at Harvard Medical School until 2010.

In 2010 Dr. Kiviranta joined Turku Collegium of Science and Medicine at the University of Turku and began to establish his own research group in the Institute of Biomedicine at the University of Turku. He also continued his residency and fellow training in Endocrinology. Dr. Riku Kiviranta received board certification of Endocrinology in 2015. He was named Adjunct Professor (Docent) in Molecular Medicine in 2013 and as an Assistant Professor in Endocrinology and Metabolic Diseases (tenure track) in 2018. Assistant Professor Kiviranta currently works as a Clinical Endocrinologist at the Turku University Hospital and leads his research group in the Institute of Biomedicine and in the Department of Clinical Medicine.


Tutkimus
Bone tissue is a dynamic endocrine organ that consists of several different cell types, the bone cells (osteoblasts, osteocytes and osteoclasts), the hematopoietic stem cells (HSCs) and their off spring, as well as bone marrow adipocytes. The complex interplay between these different cell types within the bone marrow microenvironment is essential for normal bone metabolism and bone strength and for the regulatory functions of bone tissue. Loss of normal control of the differentiation process of skeletal cells may lead to the development of osteo- or chondrosarcomas that are the most common primary malignant tumors of bone. Despite advances in the surgical treatment of skeletal sarcomas, there has been very little progress in other treatment options for these tumors.

Our research group is interested in the molecular mechanisms of these abundant cellular interactions. Moreover, we focus to unravel the essential signaling pathways that control bone cell differentiation and their mechanisms of action both on the broader chromatin landscape as well as at the promoter level. We are also working to characterize the functions and metabolic roles of bone marrow adipocytes.

Currently we have two specific areas of interest: the role of Wnt signaling and its mechanisms of action in regulating bone remodeling and the role of epigenetic regulation in the control of osteoblast differentiation and in the development of skeletal sarcomas. In both of these projects we combine clinical data and samples with modern cell and molecular biologic approaches in vitro and in genetically modified animal models.

Ultimately, our goal is to identify novel therapeutic targets  and approaches for metabolic and malignant bone diseases.


Julkaisut
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Mesenchymal Cell-Derived Juxtacrine Wnt1 Signaling Regulates Osteoblast Activity and Osteoclast Differentiation (2019)
Journal of Bone and Mineral Research
Wang F., Tarkkonen K., Nieminen-Pihala V., Nagano K., Majidi R.A., Puolakkainen T., Rummukainen P., Lehto J., Roivainen A., Zhang F.-P., Mäkitie O., Baron R., Kiviranta R.
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Cilia-related protein SPEF2 regulates osteoblast differentiation (2018)
Scientific Reports
Lehti MS, Henriksson H, Rummukainen P, Wang F, Uusitalo-Kylmala L, Kiviranta R, Heino TJ, Kotaja N, Sironen A
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Acute hormonal findings after aneurysmal subarachnoid hemorrhage - report from a single center (2017)
Endocrine Research
Takala RS, Kiviranta R, Olkkola KT, Vahlberg T, Laukka D, Kotkansalo A, Rahi M, Sankinen M, Posti J, Katila A, Rinne J.
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Changes in bone metabolism after bariatric surgery by gastric bypass or sleeve gastrectomy (2017)
BONE
Kaisa K Ivaska, Ville Huovinen, Minna Soinio, Jarna C Hannukainen, Virva Saunavaara, Paulina Salminen, Mika Helmiö, Riitta Parkkola, Pirjo Nuutila, Riku Kiviranta
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Comparative analysis of osteoblast gene expression profiles and Runx2 genomic occupancy of mouse and human osteoblasts in vitro (2017)
Gene
Tarkkonen K, Hieta R, Kytola V, Nykter M, Kiviranta R
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Soluble activin type IIB receptor improves fracture healing in a closed tibial fracture mouse model (2017)
PLoS ONE
Puolakkainen T, Rummukainen P, Lehto J, Ritvos O, Hiltunen A, Säämänen AM, Kiviranta R
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Treatment with soluble activin type IIB-receptor improves bone mass and strength in a mouse model of Duchenne muscular dystrophy (2017)
BMC Musculoskeletal Disorders
Tero Puolakkainen, Hongqian Ma, Heikki Kainulainen, Arja Pasternack, Timo Rantalainen, Olli Ritvos, Kristiina Heikinheimo, Juha J. Hulmi, Riku Kiviranta
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Bone mineral density is increased after a 16-week resistance training intervention in elderly women with decreased muscle strength (2016)
European Journal of Endocrinology
Huovinen V, Ivaska KK, Kiviranta R, Bucci M, Lipponen H, Sandboge S, Raiko J, Eriksson JG, Parkkola R, Iozzo P, Nuutila P
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Cortical-Bone Fragility - Insights from sFRP4 Deficiency in Pyle's Disease (2016)
New England Journal of Medicine
Kiper POS, Saito H, Gori F, Unger S, Hesse E, Yamana K, Kiviranta R, Solban N, Liu J, Brommage R, Boduroglu K, Bonafe L, Campos-Xavier B, Dikoglu E, Eastell R, Gossiel F, Harshman K, Nishimura G, Girisha KM, Stevenson BJ, Takita H, Rivolta C, Superti-Furga A, Baron R
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Femoral Bone Marrow Insulin Sensitivity Is Increased by Resistance Training in Elderly Female Offspring of Overweight and Obese Mothers (2016)
PLoS ONE
Ville Huovinen, Marco Bucci, Heta Lipponen, Riku Kiviranta, Samuel Sandboge, Juho Raiko, Suvi Koskinen, Kalle Koskensalo, Johan G Eriksson, Riitta Parkkola, Patricia Iozzo, Pirjo Nuutila
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Cathepsin K overexpression modifies lung development in newborn mice (2015)
Pediatric Pulmonology
Jonni Knaapi, Riku Kiviranta, Jukka Laine, Pekka Kääpä, Heikki Lukkarinen
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Vertebral bone marrow glucose uptake is inversely associated with bone marrow fat in diabetic and healthy pigs: [18F]FDG-PET and MRI study (2014)
BONE
Huovinen V., Saunavaara V., Kiviranta R., Tarkia M., Honka H., Stark C., Laine J., Linderborg K., Tuomikoski P., Badeau R., Knuuti J., Nuutila P., Parkkola R.
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages. (2013)
Journal of Experimental Medicine
Kiviranta R, Yamana K, Saito H, Ho DK, Laine J, Tarkkonen K, Nieminen-Pihala V, Hesse E, Correa D, Määttä J, Tessarollo L, Rosen ED, Horne WC, Jenkins NA, Copeland NG, Warming S, Baron R
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Does The Choice Of Surgical Technique Affect Bone Turnover Changes After Bariatric Surgery? (2013)
Journal of Bone and Mineral Research
Ivaska K, Soinio M, Hannukainen J, Salminen P, Nuutila P, Kiviranta R
(
O2 Muu)

Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation (2013)
Journal of Clinical Investigation
Lotinun S, Kiviranta R, Matsubara T, Alzate JA, Neff L, Lueth A, Koskivirta I, Kleuser B, Vacher J, Vuorio E, Horne WC, Baron R
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

WNT1 Mutations in Early-Onset Osteoporosis and Osteogenesis Imperfecta (2013)
New England Journal of Medicine
Laine CM, Joeng KS, Campeau PM, Kiviranta R, Tarkkonen K, Grover M, Lu JT, Pekkinen M, Wessman M, Heino TJ, Nieminen-Pihala V, Aronen M, Laine T, Kroger H, Cole WG, Lehesjoki AE, Nevarez L, Krakow D, Curry CJR, Cohn DH, Gibbs RA, Lee BH, Makitie O
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Regulation of Early Adipose Commitment by Zfp521 (2012)
PLoS Biology
Kang S, Akerblad P, Kiviranta R, Gupta RK, Kajimura S, Griffin MJ, Min J, Baron R, Rosen ED
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Tuki- ja liikuntaelimistön kudosten rakenne ja toiminta (2012) Ortopedia Säämänen AM, Kiviranta R, Arokoski J, Jurvelin J, Järvinen M, Kiviranta I
(
B2 Kirjan tai muun kokoomateoksen osa)

Cathepsin K deficiency aggravates lung injury in hyperoxia-exposed newborn mice (2011)
Experimental Lung Research
Knaapi J, Lukkarinen H, Kiviranta R, Vuorio E, Kaapa P
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Mice with Tissue Inhibitor of Metalloproteinases 4 (Timp4) Deletion Succumb to Induced Myocardial Infarction but Not to Cardiac Pressure Overload (2010)
Journal of Biological Chemistry
Koskivirta I, Kassiri Z, Rahkonen O, Kiviranta R, Oudit GY, Mckee TD, Kyto V, Saraste A, Jokinen E, Liu PP, Vuorio E, Khokha R
(
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)


Last updated on 2018-03-12 at 01:21