Muhammad Ashraf

tohtorikoulutettava, Anestesiologia ja tehohoito (Kliininen laitos)
tohtorikoulutettava, Kliinisen laitoksen yhteiset (Kliininen laitos)

Clinical Pharmacokinetics
Pharmacokinetic-Pharmacodynamic Modeling
Population PK/PD
Non-linear Mixed Effects Modeling

1. Ph.D. Drug Research Doctoral Programme (DRDP)
    01/10/2016 - Present
    Department of Anesthesiology and Intensive Care, University of Turku, Turku, Finland.
2. M.Sc. General Toxicology
    01/09/2013 - 06/01/2016
    University of Eastern Finland, Kuopio Finland.
3. Doctor of Pharmacy (Pharm.D)
    14/02/2007 - 30/04/2012
    Riphah International University, Islamabad Pakistan. 

Work Experience:
1. Project Researcher
    01/10/16 - Present 
    Turku University Hospital, Turku Finland.
2. Lecturer (Clinical Pharmacy/Biopharm and Pharmacokinetics)
    14/02/12 - 01/08/13
    University of Lahore, Islamabad Campus, Islamabad Pakistan.


I am working in the field of pharmacometrics, where I use the 'population approach' (i.e. non-linear mixed effects modeling) to describe the pharmacokinetic (PK) and/or pharmacokinetic-pharmacodynamic (PK-PD) behaviors of drugs in the human body. I am applying these concepts to data from ongoing clinical trials, that are being actively carried out at the Turku University Hospital, with anesthetic agents and pain medications. The rationale is to elucidate the optimal dosing schemes for these drugs for use in pain medicine, in an attempt to implement precision medicine in this area of medical care provision. 



Clinical Pharmacology


Population PK/PD Modeling 


Semimechanistic Population Pharmacokinetic Model to Predict the Drug–Drug Interaction Between S-ketamine and Ticlopidine in Healthy Human Volunteers (2018)
CPT: Pharmacometrics and Systems Pharmacology
Muhammad W. Ashraf, Marko A. Peltoniemi, Klaus T. Olkkola, Pertti J. Neuvonen, Teijo I. Saari
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Last updated on 2018-28-09 at 12:27