Kati Elima
M.D., Ph.D., Adjunct professor

Clinical Lecturer, Institute of Biomedicine (Institute of Biomedicine)
Adjunct Professor, Faculty of Medicine (Faculty of Medicine)

kateli@utu.fi
+358 29 450 4627
+358 50 477 0543

Kiinamyllynkatu 10
Turku
Medisiina C and MediCity





Areas of expertise
Molecular mechanisms of cell trafficking; medical education; postgraduate education (doctoral programmes)

Biography

Degrees and competences

- Licenciate of Medicine, 1988, University of Turku, Finland; Doctor of Medical Sciences (M.D., Ph.D.) 1990, University of Turku; Docent in Molecular Medicine, University of Turku.

- Specialist Qualification in Management 2007; General teacher qualification (university pedagogics 60 ECTS), 2014, University of Turku; Special Competence in Medical Education, 2014; Training in practical academic leadership, 2017, TSE

Current tasks

- Clinical lecturer in Molecular Medicine

- Director of Turku Doctoral Programme of Molecular Medicine (TuDMM)

- Director of Biomedical Research Track

Previous

- University of Turku: various research and teaching positions at the Department of Medical Biochemistry and Genetics, Faculty of Medicine (assistant, university teacher, clinical lecturer, associate professor, professor)

- National Institute of Health and Welfare: special investigator 

- Academy of Finland: research programme coordinator 

- Turku Graduate School of Biomedical Sciences (TuBS): coordinator 



Research

Lymphatic and vascular endothelium plays a pivotal role in leukocyte and cancer cell migration by expressing counter-receptors for the cell-surface molecules on the migrating cells that mediate trafficking. My research focuses on investigating the molecular mechanisms underlying these interactions and studying the functional role of the individual molecules in various disease processes. Special emphasis is on the roles of the large, multi-domain cell-surface molecule CLEVER-1, and the ecto-enzymes VAP-1 and CD73 in various human cancers.



Teaching

Interest areas:

- Medical education; molecular medicine; genome medicine; 

Teaching responsibilities:

- Medical Biochemistry and Molecular Medicine

- Biomedical Research Track

- Postgraduate education (doctoral programmes)

Other: 

- The Finnish Medical Society Duodecim: Head of education at the Turku region



Publications
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Fetal-derived macrophages dominate in adult mammary glands (2019)
Nature Communications
FASEB Journal
Jäppinen N., Félix I., Lokka E., Tyystjärvi S., Pynttäri A., Lahtela T., Gerke H., Elima K., Rantakari P., Salmi M.
(
A1 Journal article – refereed)

Enhanced Antibody Production in Clever-1/Stabilin-1-Deficient Mice (2018)
Frontiers in Immunology
Nature
Dunkel J, Viitala M, Karikoski M, Rantakari P, Virtakoivu R, Elima K, Hollmen M, Jalkanen S, Salmi M
(
A1 Journal article – refereed)

Amine oxidase activity regulates the development of pulmonary fibrosis (2017)
Marttila-Ichihara F, Elima K, Auvinen K, Veres TZ, Rantakari P, Weston C, Miyasaka M, Adams D, Jalkanen S, Salmi M
(
A1 Journal article – refereed)

Fetal liver endothelium regulates the seeding of tissue-resident macrophages (2016)
Rantakari P, Jappinen N, Lokka E, Mokkala E, Gerke H, Peuhu E, Ivaska J, Elima K, Auvinen K, Salmi M
(
A1 Journal article – refereed)

Gene-expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic (2016) Iftakhar-E-Khuda I, Fair-Makela R, Kukkonen-Macchi A, Elima K, Karikoski M, Rantakari P, Miyasaka M, Salmi M, Jalkanen S
(
A1 Journal article – refereed)

Monocyte stabilin-1 suppresses the activation of Th1 lymphocytes (2016)
Journal of Immunology
Senthil Palani, Kati Elima, Eeva Ekholm, Sirpa Jalkanen, Marko Salmi
(
A1 Journal article – refereed)

Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury (2016) Rantakari P, Patten DA, Valtonen J, Karikoski M, Gerke H, Dawes H, Laurila J, Ohlmeier S, Elima K, Hubscher SG, Weston CJ, Jalkanen S, Adams DH, Salmi M, Shetty S
(
A1 Journal article – refereed)

Ecto-5'-nucleotidase/CD73 enhances endothelial barrier function and sprouting in blood but not lymphatic vasculature (2015)
European Journal of Immunology
Gennady G. Yegutkin, Kaisa Auvinen, Pia Rantakari, Maija Hollmén, Marika Karikoski, Reidar Grénman, Kati Elima, Sirpa Jalkanen, Marko Salmi
(
A1 Journal article – refereed)

Primary Amine Oxidase of Escherichia coli Is a Metabolic Enzyme that Can Use a Human Leukocyte Molecule as a Substrate2015
PLoS ONE
Elovaara H, Huusko T, Maksimow M, Elima K, Yegutkin GG, Skurnik M, Dobrindt U, Siitonen A, McPherson MJ, Salmi M, Jalkanen S
(
A1 Journal article – refereed)

The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes (2015)
Nature Immunology
Rantakari P, Auvinen K, Jappinen N, Kapraali M, Valtonen J, Karikoski M, Gerke H, Iftakhar-E-Khuda I, Keuschnigg J, Umemoto E, Tohya K, Miyasaka M, Elima K, Jalkanen S, Salmi M
(
A1 Journal article – refereed)

Adenosine Inhibits Tumor Cell Invasion via Receptor-Independent Mechanisms. (2014)
Molecular Cancer Research
Virtanen SS, Kukkonen-Macchi A, Vainio M, Elima K, Härkönen PL, Jalkanen S, Yegutkin GG
(
A1 Journal article – refereed)

Clever-1/stabilin-1 controls cancer growth and metastasis (2014)
Clinical Cancer Research
Karikoski M, Marttila-Ichihara F, Elima K, Rantakari P, Hollmén M, Kelkka T, Gerke H, Huovinen V, Irjala H, Holmdahl R, Salmi M, Jalkanen S
(
A1 Journal article – refereed)

Consequences of the Lack of CD73 and Prostatic Acid Phosphatase in the Lymphoid Organs (2014)
Mediators of Inflammation
Gennady G. Yegutkin, Kaisa Auvinen, Marika Karikoski, Pia Rantakari, Heidi Gerke, Kati Elima, Mikael Maksimow, Ileana B. Quintero, Pirkko Vihko, Marko Salmi,Sirpa Jalkanen
(
A1 Journal article – refereed)

Early prediction of persistent organ failure by soluble CD73 in patients with acute pancreatitis (2014)
Critical Care Medicine
Circulation Research
Mikael Maksimow, Lea Kyhälä, Anne Nieminen, Leena Kylänpää, Kristiina Aalto, Kati Elima, Panu Mentula, Mari Lehti, Pauli Puolakkainen, Gennady G. Yegutkin, Sirpa Jalkanen, Heikki Repo, Marko Salmi
(
A1 Journal article – refereed)

Functional Modulation of Vascular Adhesion Protein-1 by a Novel Splice Variant (2013)
PLoS ONE
Kaitaniemi S, Grön K, Elovaara H, Salmi M, Jalkanen S, Elima K
(
A1 Journal article – refereed)

PV-1 is recognized by the PAL-E antibody and forms complexes with NRP-1 (2012)
Blood
Keuschnigg J, Tvorogov D, Elima K, Salmi M, Alitalo K, Salminen T, Jalkanen S
(
A1 Journal article – refereed)

Altered purinergic signaling in CD73-deficient mice inhibits tumor progression (2011)
European Journal of Immunology
Yegutkin GG, Marttila-Ichihara F, Karikoski M, Niemela J, Laurila JP, Elima K, Jalkanen S, Salmi M
(
A1 Journal article – refereed)

Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer (2011)
Blood
Aalto K, Autio A, Kiss EA, Elima K, Nymalm Y, Veres TZ, Marttila-Ichihara F, Elovaara H, Saanijoki T, Crocker PR, Maksimow M, Bligt E, Salminen TA, Salmi M, Roivainen A, Jalkanen S
(
A1 Journal article – refereed)

Clever-1/Stabilin-1 regulates lymphocyte migration within lymphatics and leukocyte entrance to sites of inflammation2009
European Journal of Immunology
Karikoski M, Irjala H, Maksimow M, Miiluniemi M, Granfors K, Hernesniemi S, Elima K, Moldenhauer G, Schledzewski K, Kzhyshkowska J, Goerdt S, Salmi M, Jalkanen SA1 Journal article – refereed


Last updated on 2019-15-07 at 02:36