Michael Courtney


Senior Research Fellow, Centre for Biotechnology (Turku Centre for Biotechnology)

miccou@utu.fi







Areas of expertise
protein interactions; cell signalling; cell imaging; optical assays; single-cell methods; optogenetics; protein engineering; neuroscience; reporter design; AAV; assay development; drug discovery; compound screening; high-throughput methods; high-content analysis; lab automation

Publications
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Disruption of nNOS–NOS1AP protein–protein interactions suppresses neuropathic pain in mice (2018)
PAIN
Wan-Hung Lee, Li-Li Li, Aarti Chawla, Andy Hudmon, Yvonne Y. Lai, Michael J. Courtney, Andrea G. Hohmann
(
A1 Journal article – refereed)

Spatial quantification of the synaptic activity phenotype across large populations of neurons with Markov random fields (2018)
Bioinformatics
Sean Robinson, Michael J. Courtney
(
A1 Journal article – refereed)

ZLc002, a putative small molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability (2018)
Molecular Pain
Lee Wan-Hung, Carey Lawrence, Li Li-Li, Xu Zhili, Lai Yvonne, Courtney Michael, Hohmann Andrea
(
A1 Journal article – refereed)

A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs (2017)
Nature Communications
de Mera RMMF, Li LL, Popinigis A, Cisek K, Tuittila M, Yadav L, Serva A, Courtney MJ
(
A1 Journal article – refereed)

Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors (2017)
PLoS ONE
von Ossowski L, Li LL, Moykkynen T, Coleman SK, Courtney MJ, Keinanen K
(
A1 Journal article – refereed)

ARHGAP12 Functions as a Developmental Brake on Excitatory Synapse Function (2016)
Cell Reports
Ba W, Selten MM, van der Raadt J, van Veen H, Li LL, Benevento M, Oudakker AR, Lasabuda RSE, Letteboer SJ, Roepman R, van Wezel RJA, Courtney MJ, van Bokhoven H, Kasri NN
(
A1 Journal article – refereed)

Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP+ Toxicity-Induced Parkinson's Disease Models (2016)
Antioxidants and Redox Signaling
Lehtonen Šárka, Jaronen Merja, Vehviläinen Piia, Lakso Merja, Rudgalvyte Martina, Keksa-Goldsteine Velta, Wong Garry, Courtney Michael J., Koistinaho Jari, Goldsteins Gundars
(
A1 Journal article – refereed)

Redox-Activated Signal Transduction Pathways Mediating Cellular Functions in Inflammation, Differentiation, Degeneration, Transformation, and Death (2016)
Oxidative Medicine and Cellular Longevity
Tetsuro Kamiya, Michael Courtney, Mikko O. Laukkanen
(
B1 Journal article)

Unexpected Heterodivalent Recruitment of NOS1AP to nNOS Reveals Multiple Sites for Pharmacological Intervention in Neuronal Disease Models (2015)
Journal of Neuroscience
XLi-Li Li, Raquel M. Melero-Fernandez de Mera, Jia Chen, Wei Ba, Nael Nadif Kasri, Mingjie Zhang, Michael J. Courtney
(
A1 Journal article – refereed)

c-Jun N-Terminal Kinase Phosphorylation of MARCKSL1 Determines Actin Stability and Migration in Neurons and in Cancer Cells (2012)
Molecular and Cellular Biology
Bjorkblom B, Padzik A, Mohammad H, Westerlund N, Komulainen E, Hollos P, Parviainen L, Papageorgiou AC, Iljin K, Kallioniemi O, Kallajoki M, Courtney MJ, Magard M, James P, Coffey ET
(
A1 Journal article – refereed)

Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate (2011)
Nature Neuroscience
Westerlund N, Zdrojewska J, Padzik A, Komulainen E, Björkblom B, Rannikko E, Tararuk T, Garcia-Frigola C, Sandholm J, Nguyen L, Kallunki T, Courtney MJ, Coffey ET
(
A1 Journal article – refereed)

Concurrent protective and destructive signaling of JNK2 in neuroblastoma cells (2009)
Cellular Signalling
Waetzig V, Wacker U, Haeusgen W, Bjorkblom B, Courtney MJ, Coffey ET, Herdegen T
(
A1 Journal article – refereed)

All JNKs can kill, but nuclear localization is critical for neuronal death (2008)
Journal of Biological Chemistry
Bjorkblom B, Vainio JC, Hongisto V, Herdegen T, Courtney MJ, Coffey ET
(
A1 Journal article – refereed)

Superior cervical ganglion-10 protein as a molecular effector of c-Jun N-terminal kinase 1: implications for the therapeutic targeting of Jun N-terminal kinase in nerve regeneration (2008)
Expert Opinion on Therapeutic Targets
Westerlund N, Zdrojewska J, Courtney MJ, Coffey ET
(
A1 Journal article – refereed)

The Wnt pool of glycogen synthase kinase 3 beta is critical for trophic-deprivation-induced neuronal death (2008)
Molecular and Cellular Biology
Hongisto V, Vainio JC, Thompson R, Courtney MJ, Coffey ET
(
A1 Journal article – refereed)

Rho mediates calcium-dependent activation of p38 alpha and subsequent excitotoxic cell death (2007)
Nature Neuroscience
Semenova MM, Maki-Hokkonen AMJ, Cao J, Komarovski V, Forsberg KM, Koistinaho M, Coffey ET, Courtney MJ
(
A1 Journal article – refereed)

JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length (vol 173, pg 265, 2006) (2006)
Journal of Cell Biology
Tararuk T, Ostman N, Li WR, Bjorkblom B, Padzik A, Zdrojewska J, Hongisto V, Herdegen T, Konopka W, Courtney MJ, Coffey ET
(
A1 Journal article – refereed)

Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: Role of microtubule-associated protein 2 as an effector (2005)
Journal of Neuroscience
Bjorkblom B, Ostman N, Hongisto V, Komarovski V, Filen JJ, Nyman TA, Kallunki T, Courtney MJ, Coffey ET
(
A1 Journal article – refereed)

The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death (2005)
Journal of Cell Biology
Cao J, Viholainen JI, Dart C, Warwick HK, Leyland ML, Courtney MJ
(
A1 Journal article – refereed)


Last updated on 2018-18-01 at 09:30