James Conway
PhD

Postdoctoral Researcher, Centre for Biotechnology (Turku Centre for Biotechnology)

james.conway@utu.fi


Biocity
Office: 4119





Publications
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Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine (2018)
Gut
Conway JR, Herrmann D, Evans TJ, Morton JP, Timpson P
(
A2 Review article in a scientific journal)

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism (2018)
Cell Metabolism
Lancaster GI, Langley KG, Berglund NA, Kammoun HL, Reibe S, Estevez E, Weir J, Mellett NA, Pernes G, Conway JRW, Lee MKS, Timpson P, Murphy AJ, Masters SL, Gerondakis S, Kaczorowski DC, Bartonicek N, Meikle PJ, Dinger ME, Febbraio MA, Bond PJ
(
A1 Journal article – refereed)

Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer (2018)
Cell Reports
Conway JRW, Warren SC, Herrmann D, Murphy KJ, Cazet AS, Vennin C, Shearer RF, Killen MJ, Magenau A, Mélénec P, Pinese M, Nobis M, Zaratzian A, Boulghourjian A, Da Silva AM, Adam ASA, Del Monte-Nieto G, Haigh JJ, Harvey RP, Croucher DR, Wang Y, Pajic M, Sansom OJ, Morton JP, Caldon CE, Timpson P
(
A1 Journal article – refereed)

MASTL overexpression promotes chromosome instability and metastasis in breast cancer (2018)
Oncogene
Rogers S, McCloy RA, Parker BL, Gallego-Ortega D, Law AMK, Chin VT, Conway JRW, Fey D, Millar EKA, O'Toole S, Deng NT, Swarbrick A, Chastain PD, Cesare AJ, Timpson P, Caldon CE, Croucher DR, James DE, Watkins DN, Burgess A
(
A1 Journal article – refereed)

Removing physiological motion from intravital and clinical functional imaging data (2018)
eLife
Warren SC, Nobis M, Magenau A, Mohammed YH, Herrmann D, Moran I, Vennin C, Conway JRW, Melenec P, Cox TR, Wang YX, Morton JP, Welch HCE, Strathdee D, Anderson KI, Phan TG, Roberts MS, Timpson P
(
A1 Journal article – refereed)

Annexin A6-A multifunctional scaffold in cell motility (2017)
Cell Adhesion and Migration
Grewal T, Hoque M, Conway JRW, Reverter M, Wahba M, Beevi SS, Timpson P, Enrich C, Rentero C
(
A2 Review article in a scientific journal)

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts (2017)
Cell Reports
Nobis M, Herrmann D, Warren SC, Kadir S, Leung W, Killen M, Magenau A, Stevenson D, Lucas MC, Reischmann N, Vennin C, Conway JRW, Boulghourjian A, Zaratzian A, Law AM, Ormandy CJ, Gallego-Ortega D, Grey ST, Walters SN, Chtanova T, Bailey J, Baldock PA, Quinn JMW, Schwarz JP, Croucher PI, Zhang L, Mrowinska A, Masedunskas A, Herzog H, Gunning PW, Hardeman EC, Samuel MS, Pajic M, Del Monte-Nieto G, Harvey RP, Sansom OJ, Welch HCE, McGhee EJ, Johnsson AE, Anderson KI, Timpson P, Morton JP, Strathdee D
(
A1 Journal article – refereed)

Context-dependent intravital imaging of therapeutic response using intramolecular FRET biosensors (2017)
Methods
Conway JRW, Warren SC, Timpson P
(
A2 Review article in a scientific journal)

SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer (2017)
Oncogene
Harris NLE, Vennin C, Conway JRW, Vine KL, Pinese M, Cowley MJ, Shearer RF, Lucas MC, Herrmann D, Allam AH, Pajic M, Morton JP, Biankin AV, Ranson M, Timpson P, Saunders DN
(
A1 Journal article – refereed)

Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology (2017)
Scientific Reports
Conway JRW, Vennin C, Cazet AS, Herrmann D, Murphy KJ, Warren SC, Wullkopf L, Boulghourjian A, Zaratzian A, Da Silva AM, Pajic M, Morton JP, Cox TR, Timpson P
(
A1 Journal article – refereed)

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis (2017)
Science Translational Medicine
Chin VT, Vennin C, Warren SC, Lucas MC, Herrmann D, Magenau A, Melenec P, Walters SN, Monte-Nieto GD, Conway JRW, Nobis M, Allam AH, McCloy RA, Currey N, Pinese M, Boulghourjian A, Zaratzian A, Adam AAS, Heu C, Nagrial AM, Chou A, Steinmann A, Drury A, Froio D, Giry-Laterriere M, Harris NLE, Phan T, Jain R, Weninger W, McGhee EJ, Whan R, Johns AL, Samra JS, Chantrill L, Gill AJ, Kohonen-Corish M, Harvey RP, Biankin AV, Evans TRJ, Anderson KI, Grey ST, Ormandy CJ, Gallego-Ortega D, Wang YX, Samuel MS, Sansom OJ, Burgess A, Cox TR, Morton JP, Pajic M, Timpson P
(
A1 Journal article – refereed)

Annexin A6 and Late Endosomal Cholesterol Modulate Integrin Recycling and Cell Migration (2016) García-Melero A, Reverter M, Hoque M, Meneses-Salas E, Koese M, Conway JR, Johnsen CH, Alvarez-Guaita A, Morales-Paytuvi F, Elmaghrabi YA, Pol A, Tebar F, Murray RZ, Timpson P, Enrich C, Rentero C, Grewal T
(
A1 Journal article – refereed)

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue (2016)
Cell Reports
Erami Z, Herrmann D, Warren SC, Nobis M, McGhee EJ, Lucas MC, Leung W, Reischmann N, Mrowinska A, Schwarz JP, Kadir S, Conway JRW, Vennin C, Karim SA, Campbell AD, Magenau A, Gallego-Ortega D, Ridgway RA, Murphy KJ, Walters SN, Law AM, Croucher DR, Grey ST, Herzog H, Zhang L, Gunning PW, Hardeman EC, Evans TRJ, Ormandy CJ, Sansom OJ, Strathdee D, Timpson P, Morton JP, Anderson KI
(
A1 Journal article – refereed)

ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells (2015)
PLoS Biology
Gallego-Ortega D, Ledger A, Roden DL, Law AM, Magenau A, Kikhtyak Z, Cho C, Allerdice SL, Lee HJ, Valdes-Mora F, Herrmann D, Salomon R, Young AI, Lee BY, Sergio CM, Piggin C, Kaplan W, Rabinovich B, Conway JR, Oakes SR, Millar EK, Swarbrick A, Chtanova T, O'Toole S, Naylor MJ, Timpson P, Green AR, Ellis IO, Gee JM, Ormandy CJ, Clark SJ
(
A1 Journal article – refereed)

The cross-talk of LDL-cholesterol with cell motility: Insights from the Niemann Pick Type C1 mutation and altered integrin trafficking (2015)
Cell Adhesion and Migration
Hoque M, Rentero C, Conway JR, Murray RZ, Timpson P, Enrich C, Grewal T
(
A1 Journal article – refereed)

The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment (2015)
Small GTPases
Pajic M, Herrmann D, Vennin C, Conway JR, Chin VT, Johnsson AK, Welch HC, Timpson P
(
A2 Review article in a scientific journal)

The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis (2015)
Cancer Cell
Ooms LM, Binge LC, Davies EM, Rahman P, Conway JR, Gurung R, Ferguson DT, Papa A, Fedele CG, Vieusseux JL, Chai RC, Koentgen F, Price JT, Tiganis T, Timpson P, Mitchell CA, McLean CA
(
A1 Journal article – refereed)

The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking (2015)
Science Signaling
Belle L, Ali N, Lonic A, Li X, Paltridge JL, Roslan S, Herrmann D, Conway JR, Gehling FK, Bert AG, Crocker LA, Tsykin A, Farshid G, Goodall GJ, Timpson P, Khew-Goodall Y, Daly RJ
(
A1 Journal article – refereed)

Cholesterol regulates Syntaxin 6 trafficking at trans-Golgi network endosomal boundaries (2014)
Cell Reports
Reverter M, Rentero C, Garcia-Melero A, Hoque M, Vilà de Muga S, Alvarez-Guaita A, Conway JR, Wood P, Cairns R, Lykopoulou L, Grinberg D, Vilageliu L, Bosch M, Heeren J, Blasi J, Pol A, Timpson P, Murray RZ, Tebar F, Enrich C, Grewal T
(
A1 Journal article – refereed)

Developments in preclinical cancer imaging: innovating the discovery of therapeutics (2014)
Nature Reviews Cancer
Conway JR, Carragher NO, Timpson P
(
A2 Review article in a scientific journal)


Last updated on 2019-22-09 at 02:20